Indonesian Journal of Obstetrics & Gynecology Science
Objective: We aim to assess the correlation between the CYP19 level, the visual analogue scale (V... more Objective: We aim to assess the correlation between the CYP19 level, the visual analogue scale (VAS) pain and endometriosis American Society for Reproductive Medicine (ASRM) grading scale. Method: An observational analytic study with a cross–sectional design was conducted at the Obstetrics/Gynecology Department, RSUP Dr. Moh Hoesin Palembang, Laboratory of Biomedical and Biomolecular of the Faculty of Medicine, Universitas Sriwijaya from July–December 2022. Subjects who were diagnosed with endometriosis and met the inclusion and exclusion criteria underwent a histopathological examination to measure the degree of disease according to ASRM. Using the same sample, the CYP19 levels were assessed by enzyme linked immunosorbent assay (ELISA). Univariate and bivariate statistical analyses were performed to see the correlation. Results: This study involved 37 subjects aged 20–48 (Mean: 32 years). We found there was a significant correlation between the degree of VAS score and ASRM grading ...
Conferences of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sriwijaya
Infertility is a common condition caused by the female factor, male factor, or both. Infertility ... more Infertility is a common condition caused by the female factor, male factor, or both. Infertility problems can have a significant impact on married couples who experience them. In addition to causing medical problems, infertility can also cause economic and psychological problems. Couples who experience infertility will undergo a long process of evaluation and treatment, where this process can be both physical and psychological for the infertile couple. The aim of this article is presenting a literature study on infertility screening. Infertility affects millions of people of reproductive age worldwide and impacts family and community life. Estimates suggest that between 48 million couples and 186 million people are living with infertility. Infertility occurs in 15% of couples. Female factors cause infertility in 50-70%, and malefactors are the cause of infertility in 40-50% of couples. Given the high prevalence of malefactors in infertility heterosexual couples, medical history and ...
Bioscientia Medicina : Journal of Biomedicine and Translational Research
Background: Endometriosis is a disease characterized by the presence of tissue resembling the end... more Background: Endometriosis is a disease characterized by the presence of tissue resembling the endometrium (uterine lining) outside the uterus. This causes a chronic inflammatory reaction that can result in the formation of scar tissue in the pelvis and other parts of the body. Pain is the most common clinical complaint in cases of endometriosis. Pain during menstruation is often confused with pain due to endometriosis, so treatment delays often occur. This study aimed to determine the relationship between menstrual patterns and pain in endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This was cross-sectional analytic observational study. A total of 55 research subjects participated in this study. Data analysis was carried out with the help of SPSS version 25 software in univariate and bivariate. Results: Menstrual cycle, duration, color, and volume of menstrual blood are not related to pain intensity in endometriosis patients. Conclusion...
The perimenopausal period refers to the time period of the menstrual cycle and endocrine changes.... more The perimenopausal period refers to the time period of the menstrual cycle and endocrine changes. Usually, it starts with a variation in the menstrual cycle length and ending with FMP. The rates of unwanted pregnancies for these women are reported to be around 40–45%. Thus, contraceptive counselling and contraceptive use among perimenopausal women are important aspects of their overall health care if they are sexually active and do not wish to become pregnant. One of them is by using low dose combined oral contraceptive pill containing ethynylestradiol (EE) containing less than 50 µg EE/day. It acts by supressing gonadotropin. There are several positive effects of COC, namely pregnancy prevention; regulation of menstrual cycle; relieving menopausal symptoms; bone protection; protection against ovarian, endometrial and colorectal cancer; lipid metabolism; and blood pressure lowering effect. In contrast, the negative effects of COC are increases the risk of breast cancer, venous throm...
Bioscientia Medicina : Journal of Biomedicine and Translational Research
Background: Several main symptoms of endometriosis can lead to physical and psychological stress ... more Background: Several main symptoms of endometriosis can lead to physical and psychological stress and also hormonal disturbances as the result of prolonged stress. Cortisol was associated with the onset of depression. This study aimed to determine the relationship between cortisol levels and depression in women with endometriosis at the Department of Obstetrics and Gynecology at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang. Methods: A cross-sectional study was performed at the Reproductive Endocrinology and Infertility outpatient clinic and inpatient ward, Department of Obstetrics and Gynecology at Dr. Mohammad Hoesin General Hospital Palembang, from January to November 2020. There were 74 samples of endometriosis patients who met the inclusion criteria. The blood cortisol level was examined using the ELISA method. The determination of depression level was performed by filling out the Beck Depression Inventory questionnaire. Data were analyzed using SPSS version 22.0. Result...
Anti-Mullerian Hormone is useful in examining folliculogenesis and ovarian abilities. Previous re... more Anti-Mullerian Hormone is useful in examining folliculogenesis and ovarian abilities. Previous research found that follicular fluid and serum in PCOS women containing high AMH levels. As therapy in PCOS with insulin resistance, metformin, an insulin sensitizer agent can be given. The efficacy of metformin therapy in inducing ovulation is more due to the local action of metformin on the ovaries rather than the systemic improvements that result both metabolically and hormonally. We conducted this study to evaluate the levels of Anti-Mullerian Hormone (AMH) in women with polycystic ovarian syndrome (PCOS) with insulin resistance before and after metformin therapy. An analytic observational study with cross-sectional design. Seventy PCOS women with insulin resistance, taking metformin for 3 months, were enrolled in this study. Serum levels of AMH was assessed before and after treatment, and the difference between them was analyzed with student t-test. Diagnosis of PCOS is made based on ...
Indonesian Journal of Obstetrics & Gynecology Science
Objective: We aim to assess the correlation between the CYP19 level, the visual analogue scale (V... more Objective: We aim to assess the correlation between the CYP19 level, the visual analogue scale (VAS) pain and endometriosis American Society for Reproductive Medicine (ASRM) grading scale. Method: An observational analytic study with a cross–sectional design was conducted at the Obstetrics/Gynecology Department, RSUP Dr. Moh Hoesin Palembang, Laboratory of Biomedical and Biomolecular of the Faculty of Medicine, Universitas Sriwijaya from July–December 2022. Subjects who were diagnosed with endometriosis and met the inclusion and exclusion criteria underwent a histopathological examination to measure the degree of disease according to ASRM. Using the same sample, the CYP19 levels were assessed by enzyme linked immunosorbent assay (ELISA). Univariate and bivariate statistical analyses were performed to see the correlation. Results: This study involved 37 subjects aged 20–48 (Mean: 32 years). We found there was a significant correlation between the degree of VAS score and ASRM grading ...
Conferences of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sriwijaya
Infertility is a common condition caused by the female factor, male factor, or both. Infertility ... more Infertility is a common condition caused by the female factor, male factor, or both. Infertility problems can have a significant impact on married couples who experience them. In addition to causing medical problems, infertility can also cause economic and psychological problems. Couples who experience infertility will undergo a long process of evaluation and treatment, where this process can be both physical and psychological for the infertile couple. The aim of this article is presenting a literature study on infertility screening. Infertility affects millions of people of reproductive age worldwide and impacts family and community life. Estimates suggest that between 48 million couples and 186 million people are living with infertility. Infertility occurs in 15% of couples. Female factors cause infertility in 50-70%, and malefactors are the cause of infertility in 40-50% of couples. Given the high prevalence of malefactors in infertility heterosexual couples, medical history and ...
Bioscientia Medicina : Journal of Biomedicine and Translational Research
Background: Endometriosis is a disease characterized by the presence of tissue resembling the end... more Background: Endometriosis is a disease characterized by the presence of tissue resembling the endometrium (uterine lining) outside the uterus. This causes a chronic inflammatory reaction that can result in the formation of scar tissue in the pelvis and other parts of the body. Pain is the most common clinical complaint in cases of endometriosis. Pain during menstruation is often confused with pain due to endometriosis, so treatment delays often occur. This study aimed to determine the relationship between menstrual patterns and pain in endometriosis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: This was cross-sectional analytic observational study. A total of 55 research subjects participated in this study. Data analysis was carried out with the help of SPSS version 25 software in univariate and bivariate. Results: Menstrual cycle, duration, color, and volume of menstrual blood are not related to pain intensity in endometriosis patients. Conclusion...
The perimenopausal period refers to the time period of the menstrual cycle and endocrine changes.... more The perimenopausal period refers to the time period of the menstrual cycle and endocrine changes. Usually, it starts with a variation in the menstrual cycle length and ending with FMP. The rates of unwanted pregnancies for these women are reported to be around 40–45%. Thus, contraceptive counselling and contraceptive use among perimenopausal women are important aspects of their overall health care if they are sexually active and do not wish to become pregnant. One of them is by using low dose combined oral contraceptive pill containing ethynylestradiol (EE) containing less than 50 µg EE/day. It acts by supressing gonadotropin. There are several positive effects of COC, namely pregnancy prevention; regulation of menstrual cycle; relieving menopausal symptoms; bone protection; protection against ovarian, endometrial and colorectal cancer; lipid metabolism; and blood pressure lowering effect. In contrast, the negative effects of COC are increases the risk of breast cancer, venous throm...
Bioscientia Medicina : Journal of Biomedicine and Translational Research
Background: Several main symptoms of endometriosis can lead to physical and psychological stress ... more Background: Several main symptoms of endometriosis can lead to physical and psychological stress and also hormonal disturbances as the result of prolonged stress. Cortisol was associated with the onset of depression. This study aimed to determine the relationship between cortisol levels and depression in women with endometriosis at the Department of Obstetrics and Gynecology at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang. Methods: A cross-sectional study was performed at the Reproductive Endocrinology and Infertility outpatient clinic and inpatient ward, Department of Obstetrics and Gynecology at Dr. Mohammad Hoesin General Hospital Palembang, from January to November 2020. There were 74 samples of endometriosis patients who met the inclusion criteria. The blood cortisol level was examined using the ELISA method. The determination of depression level was performed by filling out the Beck Depression Inventory questionnaire. Data were analyzed using SPSS version 22.0. Result...
Anti-Mullerian Hormone is useful in examining folliculogenesis and ovarian abilities. Previous re... more Anti-Mullerian Hormone is useful in examining folliculogenesis and ovarian abilities. Previous research found that follicular fluid and serum in PCOS women containing high AMH levels. As therapy in PCOS with insulin resistance, metformin, an insulin sensitizer agent can be given. The efficacy of metformin therapy in inducing ovulation is more due to the local action of metformin on the ovaries rather than the systemic improvements that result both metabolically and hormonally. We conducted this study to evaluate the levels of Anti-Mullerian Hormone (AMH) in women with polycystic ovarian syndrome (PCOS) with insulin resistance before and after metformin therapy. An analytic observational study with cross-sectional design. Seventy PCOS women with insulin resistance, taking metformin for 3 months, were enrolled in this study. Serum levels of AMH was assessed before and after treatment, and the difference between them was analyzed with student t-test. Diagnosis of PCOS is made based on ...
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