Prof. Abdel Moneim has been awarded his PhD in 2001 in and pursued a postdoctoral fellowship at University of Kobe, Japan. He is expert in “Food Science and Technology, his main concern is food microbiology. Prof. Abdel Moneim has authored a large number of articles in reputed journals, and books and has been invited to different international conferences Address: Department of Biology, Faculty of Science, University of Hail, Kingdom of Saudi Arabia
The Aja and Salma mountains in the Hail region are home to a variety of indigenous wild plants, s... more The Aja and Salma mountains in the Hail region are home to a variety of indigenous wild plants, some of which are used in Bedouin folk medicine to treat various ailments. The purpose of the current study was to unveil the chemical, antioxidant and antibacterial properties of Fagonia indica (Showeka) grown widely in these mountains, as data on the biological activities of this plant in this remote area are scarce. XRF spectrometry indicated the presence of some essential elements, which were in the order of Ca > S > K > AL > CL > Si > P > Fe > Mg > Na > Ti > Sr > Zn > Mn. Qualitative chemical screening revealed the presence of saponins, terpenes, flavonoids, tannins, phenols and cardiac glycosides in the methanolic extract (80% v/v). GC–MS showed the presence of 2-chloropropanoic acid 18.5%, tetrahydro-2-methylfuran 20.1%, tridecanoic acid 12-methyl-, methyl ester 2.2%, hexadecanoic acid, methyl ester 8.6%, methyl 3-(3,5-di-tert-butyl-4-hydroxyp...
Background Research studies have focused on discovering new anti-proliferative and pro-apoptotic ... more Background Research studies have focused on discovering new anti-proliferative and pro-apoptotic agents derived from natural products from which honey constitutes a prominent candidate. The Acacia honey (AH) is known to display anticancer activity, but the mechanisms of action are still not well defined. Objectives Using in vitro and computational approaches, we aimed to assess the interaction among selected bioactive compounds derived from AH, with the apoptotic protein p53, which could trigger apoptosis. Materials and Methods The phytocompounds of AH were investigated via gas chromatography–mass spectrophotometry analysis. The cytotoxic effect and induced apoptosis on the MCF-7 breast cancer cell line were assessed by 3-(4,5-dimethylthiazolyl-2)-2,5 diphenyltetrazolium bromide and acridine orange-ethidium bromide staining approaches. The molecular docking analysis between AH compounds and p53 was carried out. Results The drug-likeness prediction revealed that most of the identifie...
Protein tyrosine phosphatase-1B (PTP-1B) is a well-known therapeutic target for diabetes and obes... more Protein tyrosine phosphatase-1B (PTP-1B) is a well-known therapeutic target for diabetes and obesity as it suppresses insulin and leptin signaling. PTP-1B deletion or pharmacological suppression boosted glucose homeostasis and insulin signaling without altering hepatic fat storage. Inhibitors of PTP-1B may be useful in the treatment of type 2 diabetes, and shikonin, a naturally occurring naphthoquinone dye pigment, is reported to inhibit PTP-1B and possess antidiabetic properties. Since the cell contains a large number of phosphatases, PTP-1B inhibitors must be effective and selective. To explore more about the mechanism underlying the inhibitor's efficacy and selectivity, we investigated its top four pharmacophores and used site-directed mutagenesis to insert amino acid mutations into PTP-1B as an extension of our previous study where we identified 4 pharmacophores of shikonin. The study aimed to examine the site-directed mutations like R24Y, S215E, and S216C influence the binding of shikonin pharmacophores, which act as selective inhibitors of PTP-1B. To achieve this purpose, docking and molecular dynamics simulations of wild-type (WT) and mutant PTP-1B with antidiabetic compounds were undertaken. The simulation results revealed that site-directed mutations can change the hydrogen bond and hydrophobic interactions between shikonin pharmacophores and many residues in PTP-1B's active site, influencing the drug's binding affinity. These findings could aid researchers in better understanding PTP-1B inhibitors' selective binding mechanism and pave the path for the creation of effective PTP-1B inhibitors.
Diabetic peripheral neuropathy (DPN) is a common diabetes complication (DM). Aldose reductase -2 ... more Diabetic peripheral neuropathy (DPN) is a common diabetes complication (DM). Aldose reductase -2 (ALR-2) is an oxidoreductase enzyme that is most extensively studied therapeutic target for diabetes-related complications that can be inhibited by epalrestat, which has severe adverse effects; hence the discovery of potent natural inhibitors is desired. In response, a pharmacophore model based on the properties of eplarestat was generated. The specified pharmacophore model searched the NuBBEDB database of natural compounds for prospective lead candidates. To assess the drug-likeness and ADMET profile of the compounds, a series of in silico filtering procedures were applied. The compounds were then put through molecular docking and interaction analysis. In comparison to the reference drug, four compounds showed increased binding affinity and demonstrated critical residue interactions with greater stability and specificity. As a result, we have identified four potent inhibitors: ZINC00000...
Wild Fruits: Composition, Nutritional Value and Products, 2019
Grewia tenax (Gudaim) plant belongs to the family Tiliaceae. It is a medium size shrub to small t... more Grewia tenax (Gudaim) plant belongs to the family Tiliaceae. It is a medium size shrub to small tree species which is regarded as a case of multipurpose plant species since it is a wellspring of food, feed, fiber, fuel wood, timber and a scope of customary drugs that fix different hazardous ailments and have mild anti-microbial properties. Grewia tenax is a tree found in Africa and Asia. Due to its drought and salt tolerance ability, these species are abundantly spread in arid and semi arid zones, for example, sand and close mountains, particularly in the Savanna plantation territory. The fruits are utilized for advancing ripeness in females and are considered in exceptional weight control plans for pregnant ladies and pallid youngsters. The plant is adjusted to high temperatures and dry conditions and has significant roots balance out sand edges. The bushes play successfully for restoration of wastelands. The plant parts are wealthy in amino acids and mineral components and contain some pharmacologically powerful constituents. The plant is recognized in exchange for its fruits. The plant is additionally sold as wild types of therapeutic and fragrant plant and is as salary source for the innate individuals. The plant needs phytochemical and pharmacological studies on a more extensive territory which may have an incredible breadth in not so distant future. Thus, endeavors are expected to monitor, domesticate and grow the plant. The distribution of diversity, taxonomy, nutritional values, phytochemical and potential of these species are reviewed in this chapter.
Salmonella is a potential human pathogen that causes salmonellosis, a food-borne disease. Address... more Salmonella is a potential human pathogen that causes salmonellosis, a food-borne disease. Addressing these major food safety and public health issues with effective monitoring of food-borne pathogens and dietary measures. Methods: A cross-sectional study was conducted in the local markets of Alsug Alkabeer (AB), Alsug Ashabi (AK), and Alsug Alsageer (AS) sites in Wad Madani state, Sudan to detect and assess Salmonella infection in raw and cooked chicken samples. Results: The results showed that the maximum number of different Salmonella species was recovered from raw and cooked specimens of chicken obtained from AB, AK and AS which were 6.5, 4.4, and 4cfu/g, respectively. In addition, Salmonella spp. in the locally reared chicken is significantly (p < 0.05) higher than that of farm poultry. On the other hand, the highest Salmonella count was recorded in AS, AK and AB egg samples which were 5.9, 3.5, and 2.3cfu/g, respectively. Interestingly, eggs from local sources of chicken had significantly (p < 0.05) higher numbers of Salmonella spp. compared to those from farm sources. Six species of Salmonella were described, namely:
International Journal of Food Science and Nutrition Engineering, 2016
The present study aimed to investigate the effect of malting conditions on malt quality to produc... more The present study aimed to investigate the effect of malting conditions on malt quality to produce non-alcoholic sorghum malt beverage. Feterita sorghum cultivar was used to prepare the sorghum malt. Malting was carried out at two different temperatures of 25°C and 30°C for 4 and 5 days under air-rest and non-aerated conditions. Germination percentage was determined after germinating in an incubator at 30°C for 72 hours. The quality of sorghum malt in terms of malting losses, total loss, diastatic power and α and β amylase was examined. Malted grains germinated for 5 days at 30°C under non-aerated conditions had a greater effect on sorghum malt quality. For germination percentage, the results were 98% and 50% for maximum steep-out moisture. It is concluded that effective use of germination to process sorghum grain for beverage would require a control of the temperature and time. More research is needed in order to understand the adjustments made with different stages of processing o...
Food safety remains a significant challenge despite the growth and development in agricultural re... more Food safety remains a significant challenge despite the growth and development in agricultural research and the advent of modern biotechnological and agricultural tools. Though the agriculturist struggles to aid the growing population's needs, many pathogen-based plant diseases by their direct impact on cell division and tissue development have led to the loss of tons of food crops every year. Though there are many conventional and traditional methods to overcome this issue, the amount and time spend are huge. Scientists have developed systems biology tools to study the root cause of the problem and rectify it. Host-pathogen protein interactions (HPIs) have a promising role in identifying the pathogens' strategy to conquer the host organism. In this paper, the interactions between the host Rhynchophorus ferrugineus (an invasive wood-boring pest that destroys palm) and the pathogens Proteus mirabilis, Serratia marcescens, and Klebsiella pneumoniae are comprehensively studied ...
The fruits of Cordia dichotoma Forst., family Boraginaceae are used traditionally as analgesic, a... more The fruits of Cordia dichotoma Forst., family Boraginaceae are used traditionally as analgesic, anti-inflammatory, hepatoprotective, diuretic, aphrodisiac and anthelmintic. Cordia dichotoma Forst. pulp (CDP) were obtained after separation of seeds and dried at 40°C. Pulp powder contained 81.06% moisture (wet weight)), 8.86 % protein, 7.93% crude ash, 0.57% crude lipid, 10.17% crude fiber and 72.47% total carbohydrates (dry weight). The major hydrocarbon, sterol and fatty acids were eicosane-C20; 27.34%, beta-sitosterol; 7.82% and oleic acid; 46.88%. Phytochemical screening of dried pulp indicated the presence of carbohydrates, tannins, flavonoids, saponins, triterpenes, sterols, mucilage and coumarins. The results indicated that, dried pulp contained polyphenolics 2.64 g gallic/100 g, flavonoids 1.42 g quercetin/100 g, tannins 0.45g catechin/100 g and mucilage 10.74 g/100 g. IC of CDP powder, ethanolic and petroleum ether extract were 67.70, 40.05 and 50
Environmental factors such as temperature and humidity directly affect the growth and fruit bodie... more Environmental factors such as temperature and humidity directly affect the growth and fruit bodies of fungi. We studied the diversity of wood decaying fungal species, which have grown on same substrate in forest as well as laboratory environment. Ten specimens of fruit body of wood-decaying fungi and 24 random pieces of coarse wooden debris were collected from the forest of northwest Arkansas. The samples of coarse woody debris were incubated in laboratory-growth chambers for two months to promote the fungal growth. Fourty-two different species of wood-decay fungal isolates were recovered and identified by internal transcribed spacer (ITS) region sequencing. The isolates from the forest belonged to twenty-two different taxa whereas twenty taxonomic groups were reported from the growth compartments. Remarkably, data observed from two sets did not shared any taxon. These results indicated that environmental growth conditions play crucial role on fungal diversity even if grown on same ...
The Aja and Salma mountains in the Hail region are home to a variety of indigenous wild plants, s... more The Aja and Salma mountains in the Hail region are home to a variety of indigenous wild plants, some of which are used in Bedouin folk medicine to treat various ailments. The purpose of the current study was to unveil the chemical, antioxidant and antibacterial properties of Fagonia indica (Showeka) grown widely in these mountains, as data on the biological activities of this plant in this remote area are scarce. XRF spectrometry indicated the presence of some essential elements, which were in the order of Ca > S > K > AL > CL > Si > P > Fe > Mg > Na > Ti > Sr > Zn > Mn. Qualitative chemical screening revealed the presence of saponins, terpenes, flavonoids, tannins, phenols and cardiac glycosides in the methanolic extract (80% v/v). GC–MS showed the presence of 2-chloropropanoic acid 18.5%, tetrahydro-2-methylfuran 20.1%, tridecanoic acid 12-methyl-, methyl ester 2.2%, hexadecanoic acid, methyl ester 8.6%, methyl 3-(3,5-di-tert-butyl-4-hydroxyp...
Background Research studies have focused on discovering new anti-proliferative and pro-apoptotic ... more Background Research studies have focused on discovering new anti-proliferative and pro-apoptotic agents derived from natural products from which honey constitutes a prominent candidate. The Acacia honey (AH) is known to display anticancer activity, but the mechanisms of action are still not well defined. Objectives Using in vitro and computational approaches, we aimed to assess the interaction among selected bioactive compounds derived from AH, with the apoptotic protein p53, which could trigger apoptosis. Materials and Methods The phytocompounds of AH were investigated via gas chromatography–mass spectrophotometry analysis. The cytotoxic effect and induced apoptosis on the MCF-7 breast cancer cell line were assessed by 3-(4,5-dimethylthiazolyl-2)-2,5 diphenyltetrazolium bromide and acridine orange-ethidium bromide staining approaches. The molecular docking analysis between AH compounds and p53 was carried out. Results The drug-likeness prediction revealed that most of the identifie...
Protein tyrosine phosphatase-1B (PTP-1B) is a well-known therapeutic target for diabetes and obes... more Protein tyrosine phosphatase-1B (PTP-1B) is a well-known therapeutic target for diabetes and obesity as it suppresses insulin and leptin signaling. PTP-1B deletion or pharmacological suppression boosted glucose homeostasis and insulin signaling without altering hepatic fat storage. Inhibitors of PTP-1B may be useful in the treatment of type 2 diabetes, and shikonin, a naturally occurring naphthoquinone dye pigment, is reported to inhibit PTP-1B and possess antidiabetic properties. Since the cell contains a large number of phosphatases, PTP-1B inhibitors must be effective and selective. To explore more about the mechanism underlying the inhibitor's efficacy and selectivity, we investigated its top four pharmacophores and used site-directed mutagenesis to insert amino acid mutations into PTP-1B as an extension of our previous study where we identified 4 pharmacophores of shikonin. The study aimed to examine the site-directed mutations like R24Y, S215E, and S216C influence the binding of shikonin pharmacophores, which act as selective inhibitors of PTP-1B. To achieve this purpose, docking and molecular dynamics simulations of wild-type (WT) and mutant PTP-1B with antidiabetic compounds were undertaken. The simulation results revealed that site-directed mutations can change the hydrogen bond and hydrophobic interactions between shikonin pharmacophores and many residues in PTP-1B's active site, influencing the drug's binding affinity. These findings could aid researchers in better understanding PTP-1B inhibitors' selective binding mechanism and pave the path for the creation of effective PTP-1B inhibitors.
Diabetic peripheral neuropathy (DPN) is a common diabetes complication (DM). Aldose reductase -2 ... more Diabetic peripheral neuropathy (DPN) is a common diabetes complication (DM). Aldose reductase -2 (ALR-2) is an oxidoreductase enzyme that is most extensively studied therapeutic target for diabetes-related complications that can be inhibited by epalrestat, which has severe adverse effects; hence the discovery of potent natural inhibitors is desired. In response, a pharmacophore model based on the properties of eplarestat was generated. The specified pharmacophore model searched the NuBBEDB database of natural compounds for prospective lead candidates. To assess the drug-likeness and ADMET profile of the compounds, a series of in silico filtering procedures were applied. The compounds were then put through molecular docking and interaction analysis. In comparison to the reference drug, four compounds showed increased binding affinity and demonstrated critical residue interactions with greater stability and specificity. As a result, we have identified four potent inhibitors: ZINC00000...
Wild Fruits: Composition, Nutritional Value and Products, 2019
Grewia tenax (Gudaim) plant belongs to the family Tiliaceae. It is a medium size shrub to small t... more Grewia tenax (Gudaim) plant belongs to the family Tiliaceae. It is a medium size shrub to small tree species which is regarded as a case of multipurpose plant species since it is a wellspring of food, feed, fiber, fuel wood, timber and a scope of customary drugs that fix different hazardous ailments and have mild anti-microbial properties. Grewia tenax is a tree found in Africa and Asia. Due to its drought and salt tolerance ability, these species are abundantly spread in arid and semi arid zones, for example, sand and close mountains, particularly in the Savanna plantation territory. The fruits are utilized for advancing ripeness in females and are considered in exceptional weight control plans for pregnant ladies and pallid youngsters. The plant is adjusted to high temperatures and dry conditions and has significant roots balance out sand edges. The bushes play successfully for restoration of wastelands. The plant parts are wealthy in amino acids and mineral components and contain some pharmacologically powerful constituents. The plant is recognized in exchange for its fruits. The plant is additionally sold as wild types of therapeutic and fragrant plant and is as salary source for the innate individuals. The plant needs phytochemical and pharmacological studies on a more extensive territory which may have an incredible breadth in not so distant future. Thus, endeavors are expected to monitor, domesticate and grow the plant. The distribution of diversity, taxonomy, nutritional values, phytochemical and potential of these species are reviewed in this chapter.
Salmonella is a potential human pathogen that causes salmonellosis, a food-borne disease. Address... more Salmonella is a potential human pathogen that causes salmonellosis, a food-borne disease. Addressing these major food safety and public health issues with effective monitoring of food-borne pathogens and dietary measures. Methods: A cross-sectional study was conducted in the local markets of Alsug Alkabeer (AB), Alsug Ashabi (AK), and Alsug Alsageer (AS) sites in Wad Madani state, Sudan to detect and assess Salmonella infection in raw and cooked chicken samples. Results: The results showed that the maximum number of different Salmonella species was recovered from raw and cooked specimens of chicken obtained from AB, AK and AS which were 6.5, 4.4, and 4cfu/g, respectively. In addition, Salmonella spp. in the locally reared chicken is significantly (p < 0.05) higher than that of farm poultry. On the other hand, the highest Salmonella count was recorded in AS, AK and AB egg samples which were 5.9, 3.5, and 2.3cfu/g, respectively. Interestingly, eggs from local sources of chicken had significantly (p < 0.05) higher numbers of Salmonella spp. compared to those from farm sources. Six species of Salmonella were described, namely:
International Journal of Food Science and Nutrition Engineering, 2016
The present study aimed to investigate the effect of malting conditions on malt quality to produc... more The present study aimed to investigate the effect of malting conditions on malt quality to produce non-alcoholic sorghum malt beverage. Feterita sorghum cultivar was used to prepare the sorghum malt. Malting was carried out at two different temperatures of 25°C and 30°C for 4 and 5 days under air-rest and non-aerated conditions. Germination percentage was determined after germinating in an incubator at 30°C for 72 hours. The quality of sorghum malt in terms of malting losses, total loss, diastatic power and α and β amylase was examined. Malted grains germinated for 5 days at 30°C under non-aerated conditions had a greater effect on sorghum malt quality. For germination percentage, the results were 98% and 50% for maximum steep-out moisture. It is concluded that effective use of germination to process sorghum grain for beverage would require a control of the temperature and time. More research is needed in order to understand the adjustments made with different stages of processing o...
Food safety remains a significant challenge despite the growth and development in agricultural re... more Food safety remains a significant challenge despite the growth and development in agricultural research and the advent of modern biotechnological and agricultural tools. Though the agriculturist struggles to aid the growing population's needs, many pathogen-based plant diseases by their direct impact on cell division and tissue development have led to the loss of tons of food crops every year. Though there are many conventional and traditional methods to overcome this issue, the amount and time spend are huge. Scientists have developed systems biology tools to study the root cause of the problem and rectify it. Host-pathogen protein interactions (HPIs) have a promising role in identifying the pathogens' strategy to conquer the host organism. In this paper, the interactions between the host Rhynchophorus ferrugineus (an invasive wood-boring pest that destroys palm) and the pathogens Proteus mirabilis, Serratia marcescens, and Klebsiella pneumoniae are comprehensively studied ...
The fruits of Cordia dichotoma Forst., family Boraginaceae are used traditionally as analgesic, a... more The fruits of Cordia dichotoma Forst., family Boraginaceae are used traditionally as analgesic, anti-inflammatory, hepatoprotective, diuretic, aphrodisiac and anthelmintic. Cordia dichotoma Forst. pulp (CDP) were obtained after separation of seeds and dried at 40°C. Pulp powder contained 81.06% moisture (wet weight)), 8.86 % protein, 7.93% crude ash, 0.57% crude lipid, 10.17% crude fiber and 72.47% total carbohydrates (dry weight). The major hydrocarbon, sterol and fatty acids were eicosane-C20; 27.34%, beta-sitosterol; 7.82% and oleic acid; 46.88%. Phytochemical screening of dried pulp indicated the presence of carbohydrates, tannins, flavonoids, saponins, triterpenes, sterols, mucilage and coumarins. The results indicated that, dried pulp contained polyphenolics 2.64 g gallic/100 g, flavonoids 1.42 g quercetin/100 g, tannins 0.45g catechin/100 g and mucilage 10.74 g/100 g. IC of CDP powder, ethanolic and petroleum ether extract were 67.70, 40.05 and 50
Environmental factors such as temperature and humidity directly affect the growth and fruit bodie... more Environmental factors such as temperature and humidity directly affect the growth and fruit bodies of fungi. We studied the diversity of wood decaying fungal species, which have grown on same substrate in forest as well as laboratory environment. Ten specimens of fruit body of wood-decaying fungi and 24 random pieces of coarse wooden debris were collected from the forest of northwest Arkansas. The samples of coarse woody debris were incubated in laboratory-growth chambers for two months to promote the fungal growth. Fourty-two different species of wood-decay fungal isolates were recovered and identified by internal transcribed spacer (ITS) region sequencing. The isolates from the forest belonged to twenty-two different taxa whereas twenty taxonomic groups were reported from the growth compartments. Remarkably, data observed from two sets did not shared any taxon. These results indicated that environmental growth conditions play crucial role on fungal diversity even if grown on same ...
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