I am an Assistant Professor at the Faculty of Science of the University of Porto. My area of expertise is Organic Chemistry were I am engaged in the synthesis of Biocompatible Self-Assembling Surfactants for Drug Encapsulation and Delivery.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
... The asymmetric reaction chosen to study the application of (+)-(1R,endo)-2-benzonorbornenol (... more ... The asymmetric reaction chosen to study the application of (+)-(1R,endo)-2-benzonorbornenol (2) as chiral auxiliary, was the aza-Diels–Alder reaction, [12.] , [17] , [18] and [19] between cyclopentadiene and the imine ion formed in ... (c)H. Abraham and L. Stella, Tetrahedron 48 ...
Abstract The radical chain cyclization of allyl ether derivatives promoted by tosyl halides and l... more Abstract The radical chain cyclization of allyl ether derivatives promoted by tosyl halides and light is supressed by the presence of one carbonyl group conjugated with the double bond (acrylic double bond).
ABSTRACT Both exo and endo isomers of (+/-)-methyl N-diphenylphosphoryl-2-azabicyclo[2.2.1]hept-5... more ABSTRACT Both exo and endo isomers of (+/-)-methyl N-diphenylphosphoryl-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate and (+/-)-methyl N-diphenylphosphoryloxy-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate were dihydroxylated with OsO4. The unexpected formation of (+/-)-methyl 5,6-dihydroxy-N-diphenylphosphoryl-2-azabicyclo[2.2.1]heptane-3-endo-carboxylate from (+/-)-methyl N-diphenylphosphoryloxy-2-azabicyclo[2.2.1]hept-5-ene-3-endo-carboxylate is discussed based on NMR analyses and experimental observations. The two N-diphenylphosphoryl dihydroxybicycles are analyzed in terms of their crystalline structure by X-ray crystallography.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
We thank Fundacao para a Ciencia e Tecnologia and FEDER/COMPETE for financial support through gra... more We thank Fundacao para a Ciencia e Tecnologia and FEDER/COMPETE for financial support through grants UID/QUI/00081/2013, POCI-01-0145-FEDER-006980, NORTE-01-0145-FEDER-000028, and UID/QUI/50006/2013. I.S. Oliveira is also grateful to FCT for support through the PhD grant SFRH/BD/108629/2015.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Jan 24, 2018
Surface modification of ultra-small nanostructured lipid carriers (usNLC) via introduction of a p... more Surface modification of ultra-small nanostructured lipid carriers (usNLC) via introduction of a positive charge is hypothesized to prompt site-specific drug delivery for glioblastoma multiforme (GBM) treatment. A more effective interaction with negatively charged lipid bilayers, including the blood-brain barrier (BBB), will facilitate the nanoparticle access to the brain. For this purpose, usNLC relying on a novel strategy in which two different liquid compounds are combined within the solid lipid matrix, yielded a particle size of 43.82 ± 0.03 nm and a polydispersity index of 0.224. These particles were developed following a Quality by Design approach. Monomeric and gemini surfactants, either with conventional headgroups or serine-based ones, were tested for the surface modification, and the respective safety and efficacy to target GBM evaluated. A comprehensive in silico-in vitro approach is also provided based on molecular dynamics simulations and cytotoxicity studies. Overall, m...
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
... The asymmetric reaction chosen to study the application of (+)-(1R,endo)-2-benzonorbornenol (... more ... The asymmetric reaction chosen to study the application of (+)-(1R,endo)-2-benzonorbornenol (2) as chiral auxiliary, was the aza-Diels–Alder reaction, [12.] , [17] , [18] and [19] between cyclopentadiene and the imine ion formed in ... (c)H. Abraham and L. Stella, Tetrahedron 48 ...
Abstract The radical chain cyclization of allyl ether derivatives promoted by tosyl halides and l... more Abstract The radical chain cyclization of allyl ether derivatives promoted by tosyl halides and light is supressed by the presence of one carbonyl group conjugated with the double bond (acrylic double bond).
ABSTRACT Both exo and endo isomers of (+/-)-methyl N-diphenylphosphoryl-2-azabicyclo[2.2.1]hept-5... more ABSTRACT Both exo and endo isomers of (+/-)-methyl N-diphenylphosphoryl-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate and (+/-)-methyl N-diphenylphosphoryloxy-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate were dihydroxylated with OsO4. The unexpected formation of (+/-)-methyl 5,6-dihydroxy-N-diphenylphosphoryl-2-azabicyclo[2.2.1]heptane-3-endo-carboxylate from (+/-)-methyl N-diphenylphosphoryloxy-2-azabicyclo[2.2.1]hept-5-ene-3-endo-carboxylate is discussed based on NMR analyses and experimental observations. The two N-diphenylphosphoryl dihydroxybicycles are analyzed in terms of their crystalline structure by X-ray crystallography.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
We thank Fundacao para a Ciencia e Tecnologia and FEDER/COMPETE for financial support through gra... more We thank Fundacao para a Ciencia e Tecnologia and FEDER/COMPETE for financial support through grants UID/QUI/00081/2013, POCI-01-0145-FEDER-006980, NORTE-01-0145-FEDER-000028, and UID/QUI/50006/2013. I.S. Oliveira is also grateful to FCT for support through the PhD grant SFRH/BD/108629/2015.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Jan 24, 2018
Surface modification of ultra-small nanostructured lipid carriers (usNLC) via introduction of a p... more Surface modification of ultra-small nanostructured lipid carriers (usNLC) via introduction of a positive charge is hypothesized to prompt site-specific drug delivery for glioblastoma multiforme (GBM) treatment. A more effective interaction with negatively charged lipid bilayers, including the blood-brain barrier (BBB), will facilitate the nanoparticle access to the brain. For this purpose, usNLC relying on a novel strategy in which two different liquid compounds are combined within the solid lipid matrix, yielded a particle size of 43.82 ± 0.03 nm and a polydispersity index of 0.224. These particles were developed following a Quality by Design approach. Monomeric and gemini surfactants, either with conventional headgroups or serine-based ones, were tested for the surface modification, and the respective safety and efficacy to target GBM evaluated. A comprehensive in silico-in vitro approach is also provided based on molecular dynamics simulations and cytotoxicity studies. Overall, m...
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Papers by Maria Luísa Cardoso do Vale