Cliff Rosendahl is a Medical Practitioner of over 40 years’ experience,with a background in general practice and forensic medicine. His PhD project was in the field of skin cancer, particularly melanoma. Cliffcollaborated with colleagues in Brisbane and Austria to research the early diagnosis of melanoma and together they have evaluated and promoted the diagnostic method Chaos and Clues.His other major field of research is with respect to an analysis of the Skin Cancer Audit Research Database (SCARD) to assess the impact of sub-specialisation in the field of skin cancer and of the use of dermatoscopy on diagnostic accuracy with respect to melanoma.Cliff Rosendahl is a Professor at The University of Queensland, Australia where he is a course coordinator in the Master of Medicine (Skin Cancer) degree program. He is also a Visiting Professorat the School of Medicine at Tehran University of Medical Sciences, Iran.He has published over 60 papers in peer review scientific journals and is co-author of two textbooks on dermatoscopy, one of which has been published in 8 languages and he is a contributing author to several other textbooks in English and two in Spanish.Cliff has a busy schedule as an invited speaker to general practitionerand dermatologist groups both in Australia and internationally.
The Australasian journal of dermatology, Jan 23, 2018
Little is known about the dermoscopic features of atypical fibroxanthoma. This was a case-control... more Little is known about the dermoscopic features of atypical fibroxanthoma. This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer. Altogether 40 atypical fibroxanthoma were collected. Most developed in men (93%), appearing mainly as nodular (63%), amelanotic (93%) and ulcerated (78%) lesions. Most lesions were located on the scalp (55%) and the ears (13%). Dermoscopically, most atypical fibroxanthoma displayed red (83%) and white (70%) structureless areas and irregular linear vessels (43%). A series of features achieved statistical significance when comparing atypical fibroxanthoma with non-melanoma skin cancer. The presence of red and white structureless areas and white lines, and the absence of yellowish-white opaque scales, hairpin vessels and arborising vessels were predictive of atypical fibroxanthoma in univariate analysis. However, when squamous cell carcinoma was excluded from the analysis, none of the cr...
Dermoscopy improves melanoma recognition, but most criteria were described in the context of supe... more Dermoscopy improves melanoma recognition, but most criteria were described in the context of superficial spreading melanoma. To test whether pigmented nodular melanoma could be recognized dermoscopically by the presence of a combination of blue and black colour within the lesion. Dermoscopic images of histopathologically diagnosed pigmented nodular tumours with no (or only minimal) flat component were evaluated for the presence of standard melanoma criteria and for the presence of a new feature named blue-black (BB) colour. Sensitivity, specificity, positive predictive value and negative predictive value were calculated for standard criteria and BB feature in relation to the diagnosis of melanoma and to diagnosis of malignancy. Of 283 lesions, 160 were malignant, including 78 (27·6%) melanomas, and 123 were benign. The BB feature and the standard criteria had 78·2% and 43·6% sensitivity for melanoma, respectively, whereas a combined method based on the presence of either the BB feature or one (or more) of the standard criteria reached 84·6% sensitivity, with 80·5% specificity and 93·2% negative predictive value. Sensitivity values for malignant lesions were only 24·4%, 56·9% and 60% for standard criteria, BB feature and the combined method, respectively. However, the combined method gave 91·9% specificity and 90·6% positive predictive value for malignancy. Using a method based on the BB feature or one of the standard melanoma criteria, only 9·4% of positive pigmented nodular lesions were found to be benign and only 6·8% of negative lesions were found to be melanoma histopathologically.
Nevus Spitz is a benign melanocytic proliferation, first described in 1948 by Sophie Spitz as a c... more Nevus Spitz is a benign melanocytic proliferation, first described in 1948 by Sophie Spitz as a childhood melanoma. Initially, it was described as an erythematous papule or node, but further studies of the Spitz nevus proved that in 71-92% cases it is a pigmented formation. This pigmentation is often quite intense due to the rapid growth of the formation, which leads to the need for differential diagnosis with skin melanoma. After all, dermatoscopy can be used for this purpose and, when applying this research method, typically a pattern of an exploding star formed by streaks of linear pigmentation and symmetrically located pigment globules placed in the peripheral zone can be revealed. In case of non-pigmented Spitz nevus, spot vessels and reticular depigmentation are visualized. Both pigmented and non-pigmented forms of Spitz nevus in the process of evolution can regress partially or completely. Several clinical cases of different types of spitzoids, both typical and atypical, base...
Combined blue nevi (CBN) may mimic melanoma and are relatively often biopsied for diagnostic reas... more Combined blue nevi (CBN) may mimic melanoma and are relatively often biopsied for diagnostic reasons.
Journal of the European Academy of Dermatology and Venereology
Among the various types of basal cell carcinoma, the sclerodermiform variant has a high risk of r... more Among the various types of basal cell carcinoma, the sclerodermiform variant has a high risk of recurrence and local invasiveness. A systematic description of the dermatoscopic features associated with specific body localization is lacking.
1 Frisch M, Biggar RJ, Goedert JJ. Human papillomavirus-associated cancers in patients with human... more 1 Frisch M, Biggar RJ, Goedert JJ. Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst 2000; 92:1500–10. 2 Silverberg MJ, Lau B, Achenbach CJ et al. Cumulative incidence of cancer among persons with HIV in North America: a cohort study. Ann Intern Med 2015; 163:507–18. 3 Kreuter A, Potthoff A, Brockmeyer NH et al. Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany. Br J Dermatol 2010; 162:1269–77. 4 Esser S, Kreuter A, Oette M et al. German-Austrian guidelines on anal dysplasia and anal cancer in HIV-positive individuals: prevention, diagnosis, and treatment. J Dtsch Dermatol Ges 2015; 13:1302–19. 5 Brickman C, Palefsky JM. Cancer in the HIV-infected host: epidemiology and pathogenesis in the antiretroviral era. Curr HIV/AIDS Rep 2015; 12:388–96. 6 Fuchs W, Wieland U, Skaletz-Rorowski A et al. The male ScreenING Study: prevalence of HPV-related genital and anal lesions in an urban cohort of HIV-positive men in Germany. J Eur Acad Dermatol Venereol 2016; 30:995–1001. 7 Richel O, Hallensleben ND, Kreuter A et al. High-resolution anoscopy: clinical features of anal intraepithelial neoplasia in HIVpositive men. Dis Colon Rectum 2013; 56:1237–42. 8 Jay N, Berry JM, Miaskowski C et al. Colposcopic characteristics and Lugol’s staining differentiate anal high-grade and low-grade squamous intraepithelial lesions during high resolution anoscopy. Papillomavirus Res 2015; 1:101–8. 9 Siegenbeek van Heukelom ML, Richel O, de Vries HJC et al. Lowand high-risk human papillomavirus genotype infections in intra-anal warts in HIV-positive men who have sex with men. Br J Dermatol 2016; 175:735–43. 10 Berry JM, Jay N, Cranston RD et al. Progression of anal high-grade squamous intraepithelial lesions to invasive anal cancer among HIVinfected men who have sex with men. Int J Cancer 2014; 134:1147–55.
The Australasian journal of dermatology, Jan 23, 2018
Little is known about the dermoscopic features of atypical fibroxanthoma. This was a case-control... more Little is known about the dermoscopic features of atypical fibroxanthoma. This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer. Altogether 40 atypical fibroxanthoma were collected. Most developed in men (93%), appearing mainly as nodular (63%), amelanotic (93%) and ulcerated (78%) lesions. Most lesions were located on the scalp (55%) and the ears (13%). Dermoscopically, most atypical fibroxanthoma displayed red (83%) and white (70%) structureless areas and irregular linear vessels (43%). A series of features achieved statistical significance when comparing atypical fibroxanthoma with non-melanoma skin cancer. The presence of red and white structureless areas and white lines, and the absence of yellowish-white opaque scales, hairpin vessels and arborising vessels were predictive of atypical fibroxanthoma in univariate analysis. However, when squamous cell carcinoma was excluded from the analysis, none of the cr...
Dermoscopy improves melanoma recognition, but most criteria were described in the context of supe... more Dermoscopy improves melanoma recognition, but most criteria were described in the context of superficial spreading melanoma. To test whether pigmented nodular melanoma could be recognized dermoscopically by the presence of a combination of blue and black colour within the lesion. Dermoscopic images of histopathologically diagnosed pigmented nodular tumours with no (or only minimal) flat component were evaluated for the presence of standard melanoma criteria and for the presence of a new feature named blue-black (BB) colour. Sensitivity, specificity, positive predictive value and negative predictive value were calculated for standard criteria and BB feature in relation to the diagnosis of melanoma and to diagnosis of malignancy. Of 283 lesions, 160 were malignant, including 78 (27·6%) melanomas, and 123 were benign. The BB feature and the standard criteria had 78·2% and 43·6% sensitivity for melanoma, respectively, whereas a combined method based on the presence of either the BB feature or one (or more) of the standard criteria reached 84·6% sensitivity, with 80·5% specificity and 93·2% negative predictive value. Sensitivity values for malignant lesions were only 24·4%, 56·9% and 60% for standard criteria, BB feature and the combined method, respectively. However, the combined method gave 91·9% specificity and 90·6% positive predictive value for malignancy. Using a method based on the BB feature or one of the standard melanoma criteria, only 9·4% of positive pigmented nodular lesions were found to be benign and only 6·8% of negative lesions were found to be melanoma histopathologically.
Nevus Spitz is a benign melanocytic proliferation, first described in 1948 by Sophie Spitz as a c... more Nevus Spitz is a benign melanocytic proliferation, first described in 1948 by Sophie Spitz as a childhood melanoma. Initially, it was described as an erythematous papule or node, but further studies of the Spitz nevus proved that in 71-92% cases it is a pigmented formation. This pigmentation is often quite intense due to the rapid growth of the formation, which leads to the need for differential diagnosis with skin melanoma. After all, dermatoscopy can be used for this purpose and, when applying this research method, typically a pattern of an exploding star formed by streaks of linear pigmentation and symmetrically located pigment globules placed in the peripheral zone can be revealed. In case of non-pigmented Spitz nevus, spot vessels and reticular depigmentation are visualized. Both pigmented and non-pigmented forms of Spitz nevus in the process of evolution can regress partially or completely. Several clinical cases of different types of spitzoids, both typical and atypical, base...
Combined blue nevi (CBN) may mimic melanoma and are relatively often biopsied for diagnostic reas... more Combined blue nevi (CBN) may mimic melanoma and are relatively often biopsied for diagnostic reasons.
Journal of the European Academy of Dermatology and Venereology
Among the various types of basal cell carcinoma, the sclerodermiform variant has a high risk of r... more Among the various types of basal cell carcinoma, the sclerodermiform variant has a high risk of recurrence and local invasiveness. A systematic description of the dermatoscopic features associated with specific body localization is lacking.
1 Frisch M, Biggar RJ, Goedert JJ. Human papillomavirus-associated cancers in patients with human... more 1 Frisch M, Biggar RJ, Goedert JJ. Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst 2000; 92:1500–10. 2 Silverberg MJ, Lau B, Achenbach CJ et al. Cumulative incidence of cancer among persons with HIV in North America: a cohort study. Ann Intern Med 2015; 163:507–18. 3 Kreuter A, Potthoff A, Brockmeyer NH et al. Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany. Br J Dermatol 2010; 162:1269–77. 4 Esser S, Kreuter A, Oette M et al. German-Austrian guidelines on anal dysplasia and anal cancer in HIV-positive individuals: prevention, diagnosis, and treatment. J Dtsch Dermatol Ges 2015; 13:1302–19. 5 Brickman C, Palefsky JM. Cancer in the HIV-infected host: epidemiology and pathogenesis in the antiretroviral era. Curr HIV/AIDS Rep 2015; 12:388–96. 6 Fuchs W, Wieland U, Skaletz-Rorowski A et al. The male ScreenING Study: prevalence of HPV-related genital and anal lesions in an urban cohort of HIV-positive men in Germany. J Eur Acad Dermatol Venereol 2016; 30:995–1001. 7 Richel O, Hallensleben ND, Kreuter A et al. High-resolution anoscopy: clinical features of anal intraepithelial neoplasia in HIVpositive men. Dis Colon Rectum 2013; 56:1237–42. 8 Jay N, Berry JM, Miaskowski C et al. Colposcopic characteristics and Lugol’s staining differentiate anal high-grade and low-grade squamous intraepithelial lesions during high resolution anoscopy. Papillomavirus Res 2015; 1:101–8. 9 Siegenbeek van Heukelom ML, Richel O, de Vries HJC et al. Lowand high-risk human papillomavirus genotype infections in intra-anal warts in HIV-positive men who have sex with men. Br J Dermatol 2016; 175:735–43. 10 Berry JM, Jay N, Cranston RD et al. Progression of anal high-grade squamous intraepithelial lesions to invasive anal cancer among HIVinfected men who have sex with men. Int J Cancer 2014; 134:1147–55.
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