The subthalamic nucleus (STN) which contains glutamatergic neurons (Smith and Parent, 1988) has c... more The subthalamic nucleus (STN) which contains glutamatergic neurons (Smith and Parent, 1988) has come under focus in Parkinson’s disease (PD) from recent advances in the understanding of the functional organization of the basal ganglia in normal and pathological conditions. Based on this organization, normal movements would depend on an equilibrium between the activity of two output pathways from the neostriatum:
This data represents the free fatty acid (FFA) and phospholipid (PL) response to auditory fear co... more This data represents the free fatty acid (FFA) and phospholipid (PL) response to auditory fear conditioning (AFC) across the rat brain in the presence or absence of a memory blocking agent. Four experimental conditions were used, each applied to a cohort of 8 rat: saline injected (control) animals, unpaired AFC stimuli (SU); saline injected animals, paired stimuli (SP); CPP (NMDA antagonist) injected animals, unpaired AFC stimuli (CU); CPP injected animals, paired AFC stimuli (CP). Tissue was collected from 6 brain regions CeA – central amygdala, BLA – basolateral amygdala, PFC – prefrontal coretex, DH – dorsal hippocampus, VH – ventral hippocampus, CB – cerebellum Lipidomics analysis using targeted LCMSMS was performed for FFA – free fatty acid, PA – phosphatidic acid, PC- phosphatidylcholine, PE – phosphatidylcholine, PG – phosphatidylglycerol, PS – phosphatidylserine Data contains the quantified abundance for each targeted lipid species for each of the 4 AFC conditions, 8 animals, 6 brain regions
Background The globus pallidus internus is the main target for the treatment of dystonia by deep ... more Background The globus pallidus internus is the main target for the treatment of dystonia by deep brain stimulation. Unfortunately, for some genetic etiologies, the therapeutic outcome of dystonia is less predictable. In particular, therapeutic outcomes for deep brain stimulation in craniocervical and orolaryngeal dystonia in DYT6-positive patients are poor. Little is known about the neurophysiology of the globus pallidus internus in DYT6-positive dystonia, and how symptomatic treatment affects the neural activity of this region. Case presentation We present here the case of a 55-year-old Caucasian female DYT6-dystonic patient with blepharospasm, spasmodic dysphonia, and oromandibular dystonia where single-unit and local field potential activity was recorded from the globus pallidus internus during two deep brain stimulation revision surgeries 4 years apart with no symptomatic improvement. Botulinum toxin injections consistently improved dysphonia, while some of the other symptoms we...
The subthalamic nucleus (STN) which contains glutamatergic neurons (Smith and Parent, 1988) has c... more The subthalamic nucleus (STN) which contains glutamatergic neurons (Smith and Parent, 1988) has come under focus in Parkinson’s disease (PD) from recent advances in the understanding of the functional organization of the basal ganglia in normal and pathological conditions. Based on this organization, normal movements would depend on an equilibrium between the activity of two output pathways from the neostriatum:
This data represents the free fatty acid (FFA) and phospholipid (PL) response to auditory fear co... more This data represents the free fatty acid (FFA) and phospholipid (PL) response to auditory fear conditioning (AFC) across the rat brain in the presence or absence of a memory blocking agent. Four experimental conditions were used, each applied to a cohort of 8 rat: saline injected (control) animals, unpaired AFC stimuli (SU); saline injected animals, paired stimuli (SP); CPP (NMDA antagonist) injected animals, unpaired AFC stimuli (CU); CPP injected animals, paired AFC stimuli (CP). Tissue was collected from 6 brain regions CeA – central amygdala, BLA – basolateral amygdala, PFC – prefrontal coretex, DH – dorsal hippocampus, VH – ventral hippocampus, CB – cerebellum Lipidomics analysis using targeted LCMSMS was performed for FFA – free fatty acid, PA – phosphatidic acid, PC- phosphatidylcholine, PE – phosphatidylcholine, PG – phosphatidylglycerol, PS – phosphatidylserine Data contains the quantified abundance for each targeted lipid species for each of the 4 AFC conditions, 8 animals, 6 brain regions
Background The globus pallidus internus is the main target for the treatment of dystonia by deep ... more Background The globus pallidus internus is the main target for the treatment of dystonia by deep brain stimulation. Unfortunately, for some genetic etiologies, the therapeutic outcome of dystonia is less predictable. In particular, therapeutic outcomes for deep brain stimulation in craniocervical and orolaryngeal dystonia in DYT6-positive patients are poor. Little is known about the neurophysiology of the globus pallidus internus in DYT6-positive dystonia, and how symptomatic treatment affects the neural activity of this region. Case presentation We present here the case of a 55-year-old Caucasian female DYT6-dystonic patient with blepharospasm, spasmodic dysphonia, and oromandibular dystonia where single-unit and local field potential activity was recorded from the globus pallidus internus during two deep brain stimulation revision surgeries 4 years apart with no symptomatic improvement. Botulinum toxin injections consistently improved dysphonia, while some of the other symptoms we...
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