Additional file 1. Supplementary data_data extraction tables: This file contains tables of the da... more Additional file 1. Supplementary data_data extraction tables: This file contains tables of the data collected from the publications examining (1) the relationship between prenatal antibiotic exposure and the childhood allergies asthma and eczema (Tables S2a and S2b) and (2) the relationship between infant antibiotic administration and the childhood allergies asthma, eczema and hay fever (Tables S3a, S3b, S3c and S3d).
Additional file 2. Supplementary data_search strategy and process: This file has a table containi... more Additional file 2. Supplementary data_search strategy and process: This file has a table containing the search terms and strategy used for Embase and Pubmed to retrieve relevant publications (Table S1) and a flowchart depicting the search process (Figure S1).
Journal of Developmental Origins of Health and Disease, 2019
This study aimed to assess the evidence regarding the relationship between early-life antibiotic ... more This study aimed to assess the evidence regarding the relationship between early-life antibiotic exposure and childhood overweight/obesity by reviewing observational studies on prenatal antibiotic exposure and systematic reviews on infant antibiotic exposure. A search in Pubmed, Embase and Google Scholar covering the period 1st January till 1st December 2018 led to the identification of five studies on prenatal antibiotic exposure and four systematic reviews on infant antibiotic exposure. Positive trends between prenatal antibiotic exposure and overweight/obesity were reported in all studies; two studies reported a significant overall relationship and the other three reported significant relationships under certain conditions. Effect sizes ranged from odds ratio (OR): 1.04 (0.62–1.74) to relative risk (RR): 1.77 (1.25–2.51). Regarding infant antibiotics, one review concluded there was substantial evidence that infant antibiotic exposure increased the risk of childhood overweight/obe...
Background Early antibiotic exposure may be contributing to the onset of childhood allergies. The... more Background Early antibiotic exposure may be contributing to the onset of childhood allergies. The main objective of this study was to conduct a systematic review on the relationship between early life antibiotic exposure and childhood asthma, eczema and hay fever. Methods Pubmed and Embase were searched for studies published between 01-01-2008 and 01-08-2018, examining the effects of (1) prenatal antibiotic exposure and (2) infant antibiotic administration (during the first 2 years of life) on childhood asthma, eczema and hay fever from 0 to 18 years of age. These publications were assessed using the Newcastle Ottawa Scale (NOS) and analysed narratively. Results (1) Prenatal antibiotics: Asthma (12 studies): The majority of studies (9/12) reported significant relationships (range OR 1.13 (1.02–1.24) to OR 3.19 (1.52–6.67)). Three studies reported inconsistent findings. Eczema (3 studies): An overall significant effect was reported in one study and in two other studies only when pren...
Additional file 1. Supplementary data_data extraction tables: This file contains tables of the da... more Additional file 1. Supplementary data_data extraction tables: This file contains tables of the data collected from the publications examining (1) the relationship between prenatal antibiotic exposure and the childhood allergies asthma and eczema (Tables S2a and S2b) and (2) the relationship between infant antibiotic administration and the childhood allergies asthma, eczema and hay fever (Tables S3a, S3b, S3c and S3d).
Additional file 2. Supplementary data_search strategy and process: This file has a table containi... more Additional file 2. Supplementary data_search strategy and process: This file has a table containing the search terms and strategy used for Embase and Pubmed to retrieve relevant publications (Table S1) and a flowchart depicting the search process (Figure S1).
Journal of Developmental Origins of Health and Disease, 2019
This study aimed to assess the evidence regarding the relationship between early-life antibiotic ... more This study aimed to assess the evidence regarding the relationship between early-life antibiotic exposure and childhood overweight/obesity by reviewing observational studies on prenatal antibiotic exposure and systematic reviews on infant antibiotic exposure. A search in Pubmed, Embase and Google Scholar covering the period 1st January till 1st December 2018 led to the identification of five studies on prenatal antibiotic exposure and four systematic reviews on infant antibiotic exposure. Positive trends between prenatal antibiotic exposure and overweight/obesity were reported in all studies; two studies reported a significant overall relationship and the other three reported significant relationships under certain conditions. Effect sizes ranged from odds ratio (OR): 1.04 (0.62–1.74) to relative risk (RR): 1.77 (1.25–2.51). Regarding infant antibiotics, one review concluded there was substantial evidence that infant antibiotic exposure increased the risk of childhood overweight/obe...
Background Early antibiotic exposure may be contributing to the onset of childhood allergies. The... more Background Early antibiotic exposure may be contributing to the onset of childhood allergies. The main objective of this study was to conduct a systematic review on the relationship between early life antibiotic exposure and childhood asthma, eczema and hay fever. Methods Pubmed and Embase were searched for studies published between 01-01-2008 and 01-08-2018, examining the effects of (1) prenatal antibiotic exposure and (2) infant antibiotic administration (during the first 2 years of life) on childhood asthma, eczema and hay fever from 0 to 18 years of age. These publications were assessed using the Newcastle Ottawa Scale (NOS) and analysed narratively. Results (1) Prenatal antibiotics: Asthma (12 studies): The majority of studies (9/12) reported significant relationships (range OR 1.13 (1.02–1.24) to OR 3.19 (1.52–6.67)). Three studies reported inconsistent findings. Eczema (3 studies): An overall significant effect was reported in one study and in two other studies only when pren...
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