... Authors' address: Dr. C. Rosse, Department of Biological Structure, University of Washin... more ... Authors' address: Dr. C. Rosse, Department of Biological Structure, University of Washington, School of Medicine, Seattle, Wash. 98105 (USA); Drs. DA Griffiths, AE Edwards, CGC Gaches, AHL Long, JLW Wright and JM Yoffey, Department of Anatomy, University of Bristol ...
JAMA: The Journal of the American Medical Association, 1971
... Introduction to the musculoskeletal system. Post a Comment. CONTRIBUTORS: Author: Rosse,Corne... more ... Introduction to the musculoskeletal system. Post a Comment. CONTRIBUTORS: Author: Rosse,Cornelius. Author: Clawson, D. Kay (b. 1927, d. ----. PUBLISHER: Medical Dept., Harper & Row (New York). SERIES TITLE: YEAR: 1970. PUB TYPE: Book. ...
We describe an open-source toolkit that enables clinicians, researchers, and educators to build t... more We describe an open-source toolkit that enables clinicians, researchers, and educators to build their own web-based biomedical information systems. The Web Interfacing Repository Manager (Wirm) is a high-level application server aimed at medical professionals, allowing them to create individually tailored systems for managing their multimedia data and knowledge. We provide an overview of the features of Wirm, explaining how they meet the requirements for supporting biomedical information management, and describe four applications that are currently being developed with Wirm: MyPACS, a teaching file authoring system for radiologists, Fathom, an experiment management system for natural language processing, the Digital Anatomist Repository, an image archiving tool for medical schools, and Ontolog, a browser for medical vocabularies.
Transplantation of a granulocytosis-inducing murine CE mammary carcinoma into mice suppresses pri... more Transplantation of a granulocytosis-inducing murine CE mammary carcinoma into mice suppresses primary B lymphopoiesis in the marrow. The mechanisms of this tumor-induced B-cell suppression were investigated using Whitlock-Witte-type lymphoid cultures. When seeded with normal marrow progenitors, stromal cells of tumor-bearing mice supported the production of B220+ cells as well as did either stomal cells derived from control mice or the stromal cell line S17. Cultured over normal stroma, marrow cells of tumor-bearing mice depleted of adherent cells and B220+ cells generated B220+ cells as effectively as a similar cell population from control mice. However, interleukin-7- responsive progenitors, were completely depleted from the marrow of tumor-bearing mice. When conditioned medium (CM) of cloned CE tumor cells known to produce granulocyte colony-stimulating factor (G-CSF) and macrophage-CSF, or recombinant murine G-CSF was added to the cultures established with S17 cells, B220+ cell ...
Proceedings / the ... Annual Symposium on Computer Application [sic] in Medical Care. Symposium on Computer Applications in Medical Care, 1995
Although anatomical terminology forms a part of biomedical structured vocabularies, available sou... more Although anatomical terminology forms a part of biomedical structured vocabularies, available sources lack the requisite granularity, semantic types and relationships for comprehensively and consistently representing anatomical concepts in machine readable form. Thoracic angiology was selected as a proof of concept experiment for in depth representation of symbolic information in gross anatomy through the enhancement of semantic types, concepts and relationships in UMLS. Provided the representation of concepts is comprehensive, hierarchies generated with four types of simple relationships are capable of displaying anatomical information from the systemic view point with sufficient detail to meet the needs of applications in basic science education and in the practice of surgical subspecialties.
Multidetector row computed tomography (MDCT) has been used for cardiothoracic imaging since the a... more Multidetector row computed tomography (MDCT) has been used for cardiothoracic imaging since the advent of 4-slice computed tomography (CT) in 1999. Available since 2004, 64-slice CT systems are currently considered a prerequisite for successfully integrating cardiothoracic CT into routine clinical algorithms. Developments are ongoing that aim to solve the remaining challenges of cardiothoracic CT. In this review article, we focus on 3 aspects that have significantly influenced the design of newer CT scanners. (1) A faster scan speed enables coverage of the cardiothoracic anatomy in shorter scan times, which is beneficial for patients with limited ability to cooperate and opens new clinical possibilities. A coveted goal for cardiac CT is a "snapshot image" of the entire heart in 1 cardiac cycle, which can be obtained by using MDCT systems with area detectors or dual-source CT systems with electrocardiogram (ECG)-triggered high-pitch spiral. (2) Techniques to reduce the radiation dose to the patient, such as ECG-controlled dose modulation, ECG-triggered sequential CT, low kV scanning, and iterative reconstruction, have gained considerable attention as a consequence of the ongoing discussion of radiation exposure by CT. (3) New developments aim to establish a role for CT in the functional imaging of the lung and of the heart beyond the mere visualization of anatomy. Evaluation of the first-pass enhancement of the myocardium, with single-energy or with dual-energy data acquisition, and cardiac perfusion examinations may have the potential to enhance the application spectrum of cardiac CT by providing the means to determine the hemodynamic relevance of coronary artery stenosis.
... Copyright notice. The Digital Anatomist Series: 3-D, Segmented, Dynamic Atlases of Body Regio... more ... Copyright notice. The Digital Anatomist Series: 3-D, Segmented, Dynamic Atlases of Body Regions. David M. Conley, John W. Sundsten, Peter Ratiu, Wolfgang Rauschning, and Cornelius Rosse. Full text. Full text is available as a scanned copy of the original print version. ...
Radioautographic analyses were performed on PHA stimulated cultures of in vivo labelled cells obt... more Radioautographic analyses were performed on PHA stimulated cultures of in vivo labelled cells obtained from mice previously injected with 3H-TdR to selectively label either cells with a rapid renewal rate (RR) or a slow renewal rate (SR). ha responsive cells in the bone marrow (BM) were found to be virtually all RR cells, whereas both RR and SR cells from lymph nodes (LN) and spleen (Spl) were stimulated by this mitogen. However, RR cells were proportionately more responsive to PHA than SR cells in all tissues examined. Only one out of 200 BM PHA blasts belonged to the SR subclass, whereas the RR/SR ratio was approximately 1/1 for LN and 2/1 for Spl. Control experiments demonstrated that significant in vitro re-utilization of 3H-TdR from dying cells did not occur in the cultures. These results support a growing body of evidence that BM PHA responsive cells are precursor T-cells which are known to have a rapid turnover rate.
... Authors' address: Dr. C. Rosse, Department of Biological Structure, University of Washin... more ... Authors' address: Dr. C. Rosse, Department of Biological Structure, University of Washington, School of Medicine, Seattle, Wash. 98105 (USA); Drs. DA Griffiths, AE Edwards, CGC Gaches, AHL Long, JLW Wright and JM Yoffey, Department of Anatomy, University of Bristol ...
JAMA: The Journal of the American Medical Association, 1971
... Introduction to the musculoskeletal system. Post a Comment. CONTRIBUTORS: Author: Rosse,Corne... more ... Introduction to the musculoskeletal system. Post a Comment. CONTRIBUTORS: Author: Rosse,Cornelius. Author: Clawson, D. Kay (b. 1927, d. ----. PUBLISHER: Medical Dept., Harper & Row (New York). SERIES TITLE: YEAR: 1970. PUB TYPE: Book. ...
We describe an open-source toolkit that enables clinicians, researchers, and educators to build t... more We describe an open-source toolkit that enables clinicians, researchers, and educators to build their own web-based biomedical information systems. The Web Interfacing Repository Manager (Wirm) is a high-level application server aimed at medical professionals, allowing them to create individually tailored systems for managing their multimedia data and knowledge. We provide an overview of the features of Wirm, explaining how they meet the requirements for supporting biomedical information management, and describe four applications that are currently being developed with Wirm: MyPACS, a teaching file authoring system for radiologists, Fathom, an experiment management system for natural language processing, the Digital Anatomist Repository, an image archiving tool for medical schools, and Ontolog, a browser for medical vocabularies.
Transplantation of a granulocytosis-inducing murine CE mammary carcinoma into mice suppresses pri... more Transplantation of a granulocytosis-inducing murine CE mammary carcinoma into mice suppresses primary B lymphopoiesis in the marrow. The mechanisms of this tumor-induced B-cell suppression were investigated using Whitlock-Witte-type lymphoid cultures. When seeded with normal marrow progenitors, stromal cells of tumor-bearing mice supported the production of B220+ cells as well as did either stomal cells derived from control mice or the stromal cell line S17. Cultured over normal stroma, marrow cells of tumor-bearing mice depleted of adherent cells and B220+ cells generated B220+ cells as effectively as a similar cell population from control mice. However, interleukin-7- responsive progenitors, were completely depleted from the marrow of tumor-bearing mice. When conditioned medium (CM) of cloned CE tumor cells known to produce granulocyte colony-stimulating factor (G-CSF) and macrophage-CSF, or recombinant murine G-CSF was added to the cultures established with S17 cells, B220+ cell ...
Proceedings / the ... Annual Symposium on Computer Application [sic] in Medical Care. Symposium on Computer Applications in Medical Care, 1995
Although anatomical terminology forms a part of biomedical structured vocabularies, available sou... more Although anatomical terminology forms a part of biomedical structured vocabularies, available sources lack the requisite granularity, semantic types and relationships for comprehensively and consistently representing anatomical concepts in machine readable form. Thoracic angiology was selected as a proof of concept experiment for in depth representation of symbolic information in gross anatomy through the enhancement of semantic types, concepts and relationships in UMLS. Provided the representation of concepts is comprehensive, hierarchies generated with four types of simple relationships are capable of displaying anatomical information from the systemic view point with sufficient detail to meet the needs of applications in basic science education and in the practice of surgical subspecialties.
Multidetector row computed tomography (MDCT) has been used for cardiothoracic imaging since the a... more Multidetector row computed tomography (MDCT) has been used for cardiothoracic imaging since the advent of 4-slice computed tomography (CT) in 1999. Available since 2004, 64-slice CT systems are currently considered a prerequisite for successfully integrating cardiothoracic CT into routine clinical algorithms. Developments are ongoing that aim to solve the remaining challenges of cardiothoracic CT. In this review article, we focus on 3 aspects that have significantly influenced the design of newer CT scanners. (1) A faster scan speed enables coverage of the cardiothoracic anatomy in shorter scan times, which is beneficial for patients with limited ability to cooperate and opens new clinical possibilities. A coveted goal for cardiac CT is a "snapshot image" of the entire heart in 1 cardiac cycle, which can be obtained by using MDCT systems with area detectors or dual-source CT systems with electrocardiogram (ECG)-triggered high-pitch spiral. (2) Techniques to reduce the radiation dose to the patient, such as ECG-controlled dose modulation, ECG-triggered sequential CT, low kV scanning, and iterative reconstruction, have gained considerable attention as a consequence of the ongoing discussion of radiation exposure by CT. (3) New developments aim to establish a role for CT in the functional imaging of the lung and of the heart beyond the mere visualization of anatomy. Evaluation of the first-pass enhancement of the myocardium, with single-energy or with dual-energy data acquisition, and cardiac perfusion examinations may have the potential to enhance the application spectrum of cardiac CT by providing the means to determine the hemodynamic relevance of coronary artery stenosis.
... Copyright notice. The Digital Anatomist Series: 3-D, Segmented, Dynamic Atlases of Body Regio... more ... Copyright notice. The Digital Anatomist Series: 3-D, Segmented, Dynamic Atlases of Body Regions. David M. Conley, John W. Sundsten, Peter Ratiu, Wolfgang Rauschning, and Cornelius Rosse. Full text. Full text is available as a scanned copy of the original print version. ...
Radioautographic analyses were performed on PHA stimulated cultures of in vivo labelled cells obt... more Radioautographic analyses were performed on PHA stimulated cultures of in vivo labelled cells obtained from mice previously injected with 3H-TdR to selectively label either cells with a rapid renewal rate (RR) or a slow renewal rate (SR). ha responsive cells in the bone marrow (BM) were found to be virtually all RR cells, whereas both RR and SR cells from lymph nodes (LN) and spleen (Spl) were stimulated by this mitogen. However, RR cells were proportionately more responsive to PHA than SR cells in all tissues examined. Only one out of 200 BM PHA blasts belonged to the SR subclass, whereas the RR/SR ratio was approximately 1/1 for LN and 2/1 for Spl. Control experiments demonstrated that significant in vitro re-utilization of 3H-TdR from dying cells did not occur in the cultures. These results support a growing body of evidence that BM PHA responsive cells are precursor T-cells which are known to have a rapid turnover rate.
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