The existence of various native or nonnative species/fluids, along with having more than one phase in the subsurface and within the integrated production and injection systems, generates unique challenges as the pressure, temperature, composition and time (P-T-z and t) domains exhibit multi-scale characteristics. In such systems, fluid/component mixing, whether for natural reasons or man-made reasons, is one of the most complex aspects of the behavior of the system, as inherent compositions are partially or all due to these phenomena. Any time a gradient is introduced, these systems try to converge thermodynamically to an equilibrium state while being in the disequilibrium state at scale during the transitional process. These disequilibrium states create diffusive gradients, which, in the absence of flow, control the mixing processes leading to equilibrium at a certain time scale, which could also be a function of various time and length scales associated with the system. Therefore, it is crucial to understand these aspects, especially when technologies that need or utilize these concepts are under development. For example, as the technology of gas-injection-based enhanced oil recovery, CO₂ sequestration and flooding have been developed, deployed and applied to several reservoirs/aquifers worldwide, performing research on mass-transfer mechanisms between gas, oil and aqueous phases became more important, especially in terms of optimal design considerations. It is well-known that in absence of direct frontal contact and convective mixing, diffusive mixing is one of most dominant mass-transfer mechanisms, which has an impact on the effectiveness of the oil recovery and gas injection processes. Therefore, in this work, we review the fundamentals of diffusive mixing processes in general terms and summarize the theoretical, experimental and empirical studies to estimate the diffusion coefficients at high pressure—temperature conditions at various time and length scales relevant to reservoir-fluid systems. Full article

Neurotrophins and their receptors are involved in the development and maintenance of neuronal populations. Different reports have shown that all neurotrophin/receptor pathways can also play a role in several non-neuronal tissues in vertebrates, including the kidney. These signaling pathways are involved in different events to ensure the correct functioning of the kidney, such as growth, differentiation, and regulation of renal tubule transport. Previous studies in some fish species have identified the neurotrophins and receptors in the kidney. In this study, for the first time, we compare the expression profiles (mRNA and protein) of all neurotrophin/receptor pathways in the kidney of the adult zebrafish. We quantify the levels of mRNA by using qPCR and identify the expression pattern of each neurotrophin/receptor pathway by in situ hybridization. Next, we detect the proteins using Western blotting and immunohistochemistry. Our results show that among all neurotrophins analyzed, NT-3/TrkC is the most expressed in the glomerule and tubule and in the hematopoietic cells, similar to what has been reported in the mammalian kidney. Full article

This work is addressing the selective hydrogenation of alkynols over hybrid catalysts containing Pd-nanoparticles, within newly synthesized hyper-cross-linked polystyrenes (HPS). Alkynols containing C₅, C₁₀, and C₂₀ with a terminal triple bond, which are structural analogues or direct semi-products of fragrant substances and fat-soluble vitamins, have been studied. Selective hydrogenation was carried out in a batch mode (ambient hydrogen pressure, at 90 °C, in toluene solvent), using hybrid Pd catalysts with low metal content (less than 0.2 wt.%). The microporous and mesoporous HPS were both synthesized and used as supports in order to address the influence of porosity. Synthesized catalysts were shown to be active and selective: in the case of C₅, hydrogenation selectivity to the target product was more than 95%, at close to complete alkynol conversion. Mesoporous catalysts have shown some advantages in hydrogenation of long-chain alkynols. Full article

‘Ganlv 1’ is a new cultivar of Actinidia eriantha selected from the wild natural population, which has the advantages of moderate taste, high yield, easy peeling and high ascorbic acid (AsA) content. In this study, ‘Ganlv 1’ was used to explore the changes in fruit quality, soluble sugar components, sucrose metabolism-related enzymes activities and sucrose metabolism-related enzyme genes’ expression during the fruit’s development. The results showed that, except for AsA, the changes in the fruit quality index and fruit growth and development during the development of ‘Ganlv 1’ basically exhibited the same trend. The fruit shape index was different in the different development stages of the fruit, and tended to be stable with fruit growth and development. The dynamic changes of the dry matter content indicated that the best time for fruit harvest was about 160 days after full bloom. The main sugar components in the fruit were fructose, glucose and sucrose, and sucrose and glucose were the main sugars in the soft-ripening stage. The trend of sucrose accumulation, the activities of the sucrose metabolism-related enzymes and the expression of the sucrose metabolism-related genes indicated that 130–145 days after full bloom (DAFB) might be the critical period of sucrose metabolism. The results are of great significance for clarifying the developmental characteristics and dynamic changes in the sugar components in A. eriantha fruits, and lay a foundation for further studying of the mechanism of sugar metabolism in A. eriantha. Full article

In the Eastern Baltic region, severe windstorms increase both in frequency and magnitude, particularly during the dormancy period, increasing wind damage risks even more for silver birch (Betula pendula Roth.), which is considered to be less vulnerable forest tree species. Tree anchorage, particularly the properties of soil–root plate, determines the type of fatal failures trees experience under extreme wind loads and, subsequently, the potential for timber recovery during salvage logging. The link between soil–root plate properties and fatal failure types was assessed by conducting destructive static pulling tests; trees on freely draining minerals and drained deep peat soils under frozen and non-frozen soil conditions were tested. The size of the root plate did not differ between trees experiencing uprooting or stem breakage but was largely affected by soil type. Frozen soil conditions increased soil–root anchorage (via binding between soil particles) and, hence, the frequency of stem breakage without changing the size of soil–root plate. However, the lack of frozen soil conditions is among the main climatic risks for forestry within the region. The differences in the properties of soil–root plate implies plasticity in adaptation to wind loadings relative to birch, suggesting a potential for managing different types of fatal failure of trees and, subsequently, the share of retrievable timber in cases of salvage logging. Full article

The Soleil–Babinet compensator (SBC) is a variable retarder and has been used in a variety of application fields. A scheme based on the vectorial optical field is proposed to calibrate the SBC by transforming the change of the phase retardation into the visible rotation of the petal-like pattern. The relationship between the rotation angle of the petal-like pattern and the phase retardation of the SBC is established theoretically. In the experiment, the vector beam is generated by using the spiral phase plate (SPP) and the modified Mach–Zehnder interferometer based on the superposition principle of two orthogonal circularly polarized vortex beams with opposite topological charges. Taking advantage of the image processing method, the rotation angles of the acquired petal patterns are calculated, and the relationship between the phase retardation of the SBC and the displacements of its micrometer screw is determined. The measured phase retardation of the SBC ranges from −277.00° to 516.57°. By linearly fitting the experimental data, the phase sensitivity is 33.076 ± 0.147 °/mm, and the coefficient of determination value that shows the linearity of the experimental data is 0.9995. The experimental results agree well with the theoretical data. Full article

For decades since the central dogma, cancer biology research has been focusing on the involvement of genes encoding proteins. It has been not until more recent times that a new molecular class has been discovered, named non-coding RNA (ncRNA), which has been shown to play crucial roles in shaping the activity of cells. An extraordinary number of studies has shown that ncRNAs represent an extensive and prevalent group of RNAs, including both oncogenic or tumor suppressive molecules. Henceforth, various clinical trials involving ncRNAs as extraordinary biomarkers or therapies have started to emerge. In this review, we will focus on the prognostic and diagnostic role of ncRNAs for breast cancer. Full article

A rotor that can realize individual blade pitch control was designed. This paper focuses on finding the trend of helicopter vibration loads after applying multiple high-order harmonic control. The Glauert inflow model was introduced to calculate the induced velocity of rotor blades in a rotor disk plane, and the Leishman Beddoes (L-B) unsteady dynamic model was employed to calculate the aerodynamic forces of each section of a rotor blade. It was found that the influence of each high-order harmonic control on individual blade vibration load reduction is similar in different advanced ratios. After these calculations, the genetic algorithm was used to calculate the best combination of amplitude and phase of the higher order harmonic under a specific flight state. Under the effect of high harmonic input, the vibration loads of the hub could be reduced by about 65%. These results can be theoretically applied to design control law to reduce helicopter vibration loads. Full article

Severe acquired brain injury (SABI) is among the leading causes of death and disability worldwide. Patients following SABI may develop motor, sensory and cognitive disorders, alone or in combination. This review aims to point out the most used scales to assess motor function in SABI patients, also attempting to give some indications on their applicability in clinical practice. Studies were identified by searching on PubMed, Web of Science, PeDro and Cochrane databases between January and March 2022. We found that motor assessment tools are currently used by researchers/clinicians either in the acute/post-acute phase (for prognosis and rehabilitation purposes) or in the chronic phase (when functional items may also be considered). Moreover, specific scales exist only for patients with disorders of consciousness, whereas regarding motor function, SABI is mainly assessed by adapting the tools commonly used for stroke. Although some doubts remain about the validity of some of these assessment tools in SABI, to investigate motor outcomes is fundamental to establish a correct prognosis and plan a tailored rehabilitation training in these very frail and vulnerable patients. Full article

According to the World Health Organization, lower-income countries suffer from adverse health issues more than higher-income countries. Information and communication technologies (ICT) have the potential to resolve these issues. Previous research has analyzed the theoretical and empirical causal effects of ICT on infant mortality at country-specific and global levels for a short period of time. However, the causes and results could be different in low-income countries. The objective of this paper was to examine the deficiencies through the use of panel data from 27 low-income countries from 2000–2017. We applied the predictive mean matching technique to supplement the missing data and then used panel data techniques (i.e., fixed effects (FE) and pooled common correlated effects (PCCE)), and system-GMM to estimate the causal effects. We compared the consistency and the possible heterogeneity of previous results using a set of robust techniques and empirical tests. We found that internet access and, to a lesser extent, cellular mobile subscriptions, two of the three ICT variables used in our research, had a significant positive effect on reducing infant mortality in low-income countries. In conclusion, governments and policymakers of low-income countries should consider the availability of internet-related ICT innovations and make them nationally accessible to reduce health crises such as the infant mortality rate. Full article

Free convective flow in a cubical cavity loaded with copper-water nanofluid was examined numerically by employing a non-homogeneous dynamic model, which is physically more realistic in representing nanofluids than homogenous ones. The cavity was introduced to a horizontal magnetic field from the left sidewall. Both the cavity’s vertical left and right sidewalls are preserved at an isothermal cold temperature (T_c). The cavity includes inside it four isothermal heating blocks in the middle of the top and bottom walls. The other cavity walls are assumed adiabatic. Simulations were performed for solid volume fraction ranging from (0 ≤ ≤ 0.06), Rayleigh number varied as (10³ ≤ Ra ≤ 10⁵), the Hartmann number varied as (0 ≤ Ha ≤ 60), and the diameter of nanoparticle varied as (10 nm ≤ d_p ≤ 130 nm). It was found that at (d_p = 10 nm), the average Nusselt number declines when Ha increases, whereas it increases as (Ra) and () increase. Furthermore, the increasing impact of the magnetic field on the average Nusselt number is absent for (Ra = 10³), and this can be seen for all values of (). However, when (d_p) is considered variable, the average Nusselt number was directly proportional to (Ra) and () and inversely proportional to (d_p). Full article

Microcystins appear to be considered one of the most dangerous cyanobacterial toxins in the world. The accumulation and change of microcystins MC-LR and MC-RR in the “cyanobacteria–cladocera–fish” food chain were studied. Microcystis aeruginosa was fed to Moina macrocopa at three densities, 5.0 × 10³, 5.0 × 10⁵, and 5.0 × 10⁶ cells/mL, and then passed to Cyprinus flammans. The total amount of MCs in the cyanobacteria cell extract increased with increasing density. The content of MCs in M. macrocopa increased with the feeding density of M. aeruginosa. In the final stage of experiments, MC-RR was the only MC that could be transmitted by M. macrocopa and persisted in red carp. In this study, changes in the concentrations of MC-LR and MC-RR in the liver of red carp seem to indicate some kind of transformation or degradation mechanism. It shows the possibility of MCs concentration-controlled biodefense in eutrophic waters. Full article

Background: Athletes should be distinguished by their capacity to deal with stress effectively. Motivated soccer players will employ stress-coping strategies that are linked to their ability to perform at a high level. The purpose of this study is to determine the relationship between a player’s specific goal orientation, coping in sports, and the effectiveness of play during competition. Methods: The study enrolled 122 male elite soccer players at the championship level who were between the ages of 16 and 19. All participants completed the Polish version of the Task and Ego Orientation in Sport Questionnaire, the Polish version of the Coping Inventory for Competitive Sport Questionnaire, the CISS questionnaire, and Szwarc’s observation sheet for evaluating soccer performance. Results: The results showed that the task-based stress-coping mode partially mediated the relationship between task motivation and the observed effectiveness of players in soccer. Conclusion: From an applied perspective, the data on the relationship between selected mental factors and soccer performance point to a possible direction of work for players aspiring to the highest level of performance. Full article

This review aims to provide an up-to-date, comprehensive, and systematic summary of fault detection and diagnosis (FDD) in building systems. The latter was performed through a defined systematic methodology with the final selection of 221 studies. This review provides insights into four topics: (1) glossary framework of the FDD processes; (2) a classification scheme using energy system terminologies as the starting point; (3) the data, code, and performance evaluation metrics used in the reviewed literature; and (4) future research outlooks. FDD is a known and well-developed field in the aerospace, energy, and automotive sector. Nevertheless, this study found that FDD for building systems is still at an early stage worldwide. This was evident through the ongoing development of algorithms for detecting and diagnosing faults in building systems and the inconsistent use of the terminologies and definitions. In addition, there was an apparent lack of data statements in the reviewed articles, which compromised the reproducibility, and thus the practical development in this field. Furthermore, as data drove the research activity, the found dataset repositories and open code are also presented in this review. Finally, all data and documentation presented in this review are open and available in a GitHub repository. Full article

The aims of this research are to assess the level of satisfaction with medical care among patients treated in osteoporosis clinics and to determine the relationship among the frequency of visits to the doctor, the duration of treatment, socio-demographic factors, and patient satisfaction with the medical care they receive. The study was conducted from August 2016 to July 2018 at osteoporosis clinics in eastern Poland. The study participants were 312 patients treated for osteopenia or osteoporosis. The authors utilized two research instruments: the PASAT POZ questionnaire and their own questionnaire. The results indicate that the duration of osteoporosis treatment is a factor that significantly influences the level of satisfaction with medical care: the longer the treatment time, the poorer the assessment of the clinic, and therefore, the lower the patient degree of satisfaction. Our analysis shows that women assess clinics more positively overall. Additionally, the higher the study participants’ age, the lower the general assessment of the clinic. A further analysis showed that respondents in better financial situations and with higher levels of education tended to assess clinics more favorably. The Pareto-Lorenz analysis indicated that the key element in general assessments of specialist clinics is the doctor. It is advisable for health service providers to monitor the quality of health care they are providing and make improvements. Therefore, further research is needed, especially in relation to chronic diseases such as osteoporosis. Full article

Influenza A viruses (IAVs) have a main natural reservoir in wild birds. IAVs are highly contagious, continually evolve, and have a wide host range that includes various mammalian species including horses, pigs, and humans. Furthering our understanding of host-pathogen interactions and cross-species transmissions is therefore essential. This review focuses on what is known regarding equine influenza virus (EIV) virology, pathogenesis, immune responses, clinical aspects, epidemiology (including factors contributing to local, national, and international transmission), surveillance, and preventive measures such as vaccines. We compare EIV and human influenza viruses and discuss parallels that can be drawn between them. We highlight differences in evolutionary rates between EIV and human IAVs, their impact on antigenic drift, and vaccine strain updates. We also describe the approaches used for the control of equine influenza (EI), which originated from those used in the human field, including surveillance networks and virological analysis methods. Finally, as vaccination in both species remains the cornerstone of disease mitigation, vaccine technologies and vaccination strategies against influenza in horses and humans are compared and discussed. Full article

(1) Background: Several agencies in the United States play a primary role in ensuring food safety, yet foodborne illnesses result in about 3000 deaths and cost more than USD 15.6 billion each year. The study objectives included analyzing local health departments’ (LHDs) level of engagement in food safety and other related services, and LHDs’ characteristics associated with those services. (2) Methods: We used data from 1496 LHDs that participated in the 2019 National Profile of Local Health Departments Survey, administered to all 2459 LHDs in the United States. Logistic regression analyses were performed to model multiple dichotomous variables. (3) Results: An estimated 78.9% of LHDs performed food safety inspections, 78.3% provided food safety education, 40.7% provided food processing inspections, and 48.4% engaged in policy and advocacy. The odds for LHDs to directly provide preventive nutrition services were 20 times higher if the LHDs had one or more nutritionists on staff (Adjusted Odds Ratio or AOR = 20.0; Confidence Interval, CI = 12.4–32.2) compared with LHDs with no nutritionists. Other LHD characteristics significantly associated with the provision of nutrition services (p < 0.05) included population size, state governance (rather than local), and LHD having at least one registered, licensed, practical, or vocational nurse. The odds of providing food processing services were lower for locally governed than state-governed LHDs (AOR = 0.5; CI = 0.4–0.7). The odds of performing food safety inspections varied by LHD’s population size, whether a nutritionist was on staff, whether it was state-governed (vs. locally), and whether it completed a community health assessment (CHA) within 5 years. (4) Conclusions: LHDs play a critical role in ensuring safe food for Americans, yet variations exist in their performance based on their specific characteristics. Adequate funding and a competent workforce are essential for LHDs to utilize evidence-based practices and engage in policymaking and advocacy concerning food safety. Full article

Although chemotherapeutic treatment regimens are currently available, and considerable effort has been lavished on the development of new drugs for the treatment of tuberculosis (TB), the disease remains deeply intractable and widespread. This is due not only to the nature of the life cycle and extraordinarily disseminated habitat of the causative pathogen, principally Mycobacterium tuberculosis (Mtb), in humans and the multi-drug resistance of Mtb to current drugs, but especially also to the difficulty of enabling universal treatment of individuals, immunocompromised or otherwise, in widely differing socio-economic environments. For the purpose of globally eliminating TB by 2035, the World Health Organization (WHO) introduced the “End-TB” initiative by employing interventions focusing on high impact, integrated and patient-centered approaches, such as individualized therapy. However, the extraordinary shortfall in stipulated aims, for example in actual treatment and in TB preventative treatments during the period 2018–2022, latterly and greatly exacerbated by the COVID-19 pandemic, means that even greater pressure is now placed on enhancing our scientific understanding of the disease, repurposing or repositioning old drugs and developing new drugs as well as evolving innovative treatment methods. In the specific context of multidrug resistant Mtb, it is furthermore noted that the incidence of extra-pulmonary TB (EPTB) has significantly increased. This review focusses on the potential of utilizing self-double-emulsifying drug delivery systems (SDEDDSs) as topical drug delivery systems for the dermal route of administration to aid in treatment of cutaneous TB (CTB) and other mycobacterial infections as a prelude to evaluating related systems for more effective treatment of CTB and other mycobacterial infections at large. As a starting point, we consider here the possibility of adapting the highly lipophilic riminophenazine clofazimine, with its potential for treatment of multi-drug resistant TB, for this purpose. Additionally, recently reported synergism achieved by adding clofazimine to first-line TB regimens signifies the need to consider clofazimine. Thus, the biological effects and pharmacology of clofazimine are reviewed. The potential of plant-based oils acting as emulsifiers, skin penetration enhancers as well as these materials behaving as anti-microbial components for transporting the incorporated drug are also discussed. Full article

The emergence of low-cost air quality sensors as viable tools for the monitoring of air quality at population and individual levels necessitates the evaluation of these instruments. The Flow air quality tracker, a product of Plume Labs, is one such sensor. To evaluate these sensors, we assessed 34 of them in a controlled laboratory setting by exposing them to PM₁₀ and PM_2.5 and compared the response with Plantower A003 measurements. The overall coefficient of determination (R²) of measured PM_2.5 was 0.76 and of PM₁₀ it was 0.73, but the Flows’ accuracy improved after each introduction of incense. Overall, these findings suggest that the Flow can be a useful air quality monitoring tool in air pollution areas with higher concentrations, when incorporated into other monitoring frameworks and when used in aggregate. The broader environmental implications of this work are that it is possible for individuals and groups to monitor their individual exposure to particulate matter pollution. Full article

With the wide application of hydraulic servo technology in control systems, the requirement of hydraulic servo position control performance is greater and greater. In order to solve the problems of slow response, poor precision, and weak anti-interference ability in hydraulic servo position controls, a Kalman genetic optimization PID controller is designed. Firstly, aiming at the nonlinear problems such as internal leakage and oil compressibility in the hydraulic servo system, the mathematical model of the hydraulic servo system is established. By analyzing the working characteristics of the servo valve and hydraulic cylinder in the hydraulic servo system, the parameters in the mathematical model are determined. Secondly, a genetic algorithm is used to search the optimal proportional integral differential (PID) controller gain of the hydraulic servo system to realize the accurate control of valve-controlled hydraulic cylinder displacement in the hydraulic servo system. Under the positioning benchmark of step signal and sine wave signal, the PID algorithm and the genetic optimized PID algorithm are compared in the system simulation model established by Simulink. Finally, to solve the amplitude fluctuations caused by the GA optimized PID and reduce the influence of external disturbances, a Kalman filtering algorithm is added to the hydraulic servo system to reduce the amplitude fluctuations and the influence of external disturbances on the system. The simulation results show that the designed Kalman genetic optimization PID controller can be better applied to the position control of the hydraulic servo system. Compared with the traditional PID control algorithm, the PID algorithm optimized by genetic algorithm improves the system’s response speed and control accuracy; the Kalman filter is a good solution for the amplitude fluctuations caused by GA-optimized PID that reduces the influence of external disturbances on the hydraulic servo system. Full article

This paper addresses the issue of assessing the sustainability of policy decisions of the Energy Retail Market, explicitly considering the retail energy market, unlike existing approaches in the literature that analyze the energy market as a whole. The sustainability assessment is treated as the process by which the sustainability implications of an initiative are assessed, where the initiative can be a proposed or existing policy, plan, program, project, piece of legislation, or current practice or activity. The paper provides a comprehensive overview of the state of the literature on the sustainability of policy decisions in the retail energy sector and formulates a conceptual framework for policy sustainability analysis in the retail energy sector. The systematic review is complemented by a quantitative bibliometric analysis on the 48 collected papers published from 1997 to 2022. The proposed framework allows for a balanced analysis of the sustainability of policy decisions by evaluating the technical, economic, and environmental impacts. It could be used to develop a list of indicators that can map the different impacts and their interactions. Critical analysis of the existing findings leads us to identify future research directions. Full article

Although religious freedom significantly affects certain people, the guarantees for its observance also have implications for the quality of social life and the security of the state. Polarization and conflict between religious groups is not only a conflict for new believers, but also contributes to the weakening of the internal state. It seems that one of the elements of such a destabilization of states is the promotion and lack of reaction to the phenomenon of ridiculing religion and its followers in cyberspace. As can be seen from reports on the situation in Poland, there are increasing signs of hostility to religion, stereotyping, and discrimination. The issues can be considered on two levels: individual protection for freedom of speech, and state protection. At the end of this paper, proposals for measures to prevent crimes based on religion or belief are presented. Full article

In vitro transcribed mRNA for the synthesis of any given protein has shown great potential in cancer gene therapy, especially in cancer vaccines for immunotherapy. To overcome physiological barriers, such as rapid degradation by enzymatic attack and poor cellular uptake due to their large size and hydrophilic properties, many delivery carriers for mRNAs are being investigated for improving the bioavailability of mRNA. Recently, cell-penetrating peptides (CPPs) have received attention as promising tools for gene delivery. In terms of their biocompatibility and the ability to target specific cells with the versatility of peptide sequences, they may provide clues to address the challenges of conventional delivery systems for cancer mRNA delivery. In this study, optimal conditions for the CPP/mRNA complexes were identified in terms of complexation capacity and N/P ratio, and protection against RNase was confirmed. When cancer cells were treated at a concentration of 6.8 nM, which could deliver the highest amount of mRNA without toxicity, the amphipathic CPP/mRNA complexes with a size less than 200 nm showed high cellular uptake and protein expression. With advances in our understanding of CPPs, CPPs designed to target tumor tissues will be promising for use in developing a new class of mRNA delivery vehicles in cancer therapy. Full article