Background: Increased knowledge of the pharmacokinetic characteristics of orally administered levothyroxine (L-T₄) has improved individualization of dosing regimens. However, up to 40–45% of patients, depending on the leading cause of hypothyroidism, are still over- or, more often, undertreated. Unintentional non-adherence to L-T₄ replacement therapy includes all situations of unintended drug–drug and drug–food interactions as well as fasting conditions that are not necessarily respected by patients. Results: In this specific context, the overall information concerning those factors with the potential to affect L-T₄ absorption refers only to tablet formulation. Indeed, this is the reason why new non-tablet formulations of L-T₄ were introduced some years ago. In this regard, the current literature review was designed to summarize pharmacokinetic, drug and food interactions and clinical data focusing on two new oral L-T4 formulations, i.e., liquid and soft-gel capsule in healthy volunteers and patients with primary hypothyroidism. The non-tablet L-T₄ soft-gel capsules and solution have proven bioequivalence with the usual L-T₄ tablet Princeps and generic formulations. Clinical studies have suggested higher performance of non-tablet formulations than tablet in those patients with suboptimal adherence. The impact of gastrointestinal conditions and variation of gastric pH was lower with either soft gel/solution than with tablets. In addition, the extent of drug–drug and drug–food interactions remains low and of uncertain clinical relevance. Conclusions: Pending further studies allowing one to extend the use of soft-gel/solution preparations in unselected patients, non-tablet L-T₄ formulations should be considered as a first-line choice, especially in those patients with moderate-to-high potential of suboptimal tablet performance. Full article

This paper considers a modified Erlang loss system for cognitive wireless networks and related applications. A primary user has pre-emptive priority over secondary users, and the primary customer is lost if upon arrival all the channels are used by other primary users. Secondary users cognitively use idle channels, and they can stay (either in an infinite buffer or in an orbit) in cases where idle channels are not available upon arrival or they are interrupted by primary users. While the infinite buffer model represents the case with zero sensing time, the infinite orbit model represents the case with positive sensing time. We obtain an explicit stability condition for the cases where arrival processes of primary users and secondary users follow Poisson processes, and their service times follow two distinct arbitrary distributions. The stability condition is insensitive to the service time distributions and implies the maximal throughout of secondary users. Moreover, we extend the stability analysis to the system with outgoing calls. For a special case of exponential service time distributions, we analyze the buffered system in depth to show the effect of parameters on the delay performance and the mean number of interruptions of secondary users. Our simulations for distributions rather than exponential reveal that the mean number of terminations for secondary users is less sensitive to the service time distribution of primary users. Full article

Background: Low-income U.S. adults experiencing food insecurity have a disproportionately high prevalence of cigarette smoking, and quantitative studies suggest that food insecurity is a barrier to quitting. To guide effective tobacco control strategies, this study aimed to understand the experiences, perceptions, and context of tobacco use and cessation among low-income populations experiencing food insecurity. Methods: We conducted in-depth, semi-structured interviews with 23 adults who were currently smoking cigarettes and were experiencing food insecurity, mostly living in rural settings. Participants were recruited through food-pantry-based needs assessment surveys and study flyers in community-based organizations. The interview guide explored participants’ histories of smoking, the role and function of tobacco in their lives, their interest in and barriers to quitting, as well as lived experiences of food insecurity. We used reflexive thematic analysis to analyze transcribed interviews. Results: Within a broader context of structural challenges related to poverty and financial strain that shaped current smoking behavior and experiences with food insecurity, we identified the following five themes: smoking to ignore hunger or eat less; staying addicted to smoking in the midst of instability; smoking being prioritized in the midst of financial strain; life stressors and the difficulty of quitting smoking and staying quit; and childhood adversity at the intersection of food insecurity and tobacco use. Conclusion: The context of tobacco use among adults with food insecurity was highly complex. To effectively address tobacco-related disparities among those who are socially and economically disadvantaged, tobacco control efforts should consider relevant lived experiences and structural constraints intersecting smoking and food insecurity. Findings are applied to a conceptualization of clustering of conditions contributing to nicotine dependence, food insecurity, and stress. Full article

Chronic and recurrent bacterial infections are frequently associated with the formation of biofilms on biotic or abiotic materials that are composed of mono- or multi-species cultures of bacteria/fungi embedded in an extracellular matrix produced by the microorganisms. Biofilm formation is, among others, regulated by quorum sensing (QS) which is an interbacterial communication system usually composed of two-component systems (TCSs) of secreted autoinducer compounds that activate signal transduction pathways through interaction with their respective receptors. Embedded in the biofilms, the bacteria are protected from environmental stress stimuli, and they often show reduced responses to antibiotics, making it difficult to eradicate the bacterial infection. Besides reduced penetration of antibiotics through the intricate structure of the biofilms, the sessile biofilm-embedded bacteria show reduced metabolic activity making them intrinsically less sensitive to antibiotics. Moreover, they frequently express elevated levels of efflux pumps that extrude antibiotics, thereby reducing their intracellular levels. Some efflux pumps are involved in the secretion of QS compounds and biofilm-related materials, besides being important for removing toxic substances from the bacteria. Some efflux pump inhibitors (EPIs) have been shown to both prevent biofilm formation and sensitize the bacteria to antibiotics, suggesting a relationship between these processes. Additionally, QS inhibitors or quenchers may affect antibiotic susceptibility. Thus, targeting elements that regulate QS and biofilm formation might be a promising approach to combat antibiotic-resistant biofilm-related bacterial infections. Full article

The diagnosis of intestinal parasitic infections still widely relies on microscopic examination of stools and requires reliable reagents and staff expertise. The ParaFlo^® assays (Eurobio Ingen) are ready-to-use concentration methods for parasite egg detection, and they could improve reagent traceability and ease of manipulation. Ninety-three stool samples were analyzed with the ParaFlo^® concentration methods and then compared with routine microscopic methods for protozoa and helminth detection: seventy-eight were analyzed with ParaFlo^® Bailenger and in-house Thebault or Bailenger concentrations, and fifty-five were analyzed with ParaFlo^®DC and the in-house merthiolate-formalin diphasic concentration (DC) method. Fully concordant results were obtained for 75%, 70%, and 69% of samples when comparing ParaFlo^® DC and in-house DC, ParaFlo^® Bailenger and in-house Bailenger, and ParaFlo^® Bailenger and Thebault, respectively. The performances of the ParaFlo^® assays did not differ statistically from that obtained with their in-house counterparts (Bailenger and DC) for the detection of protozoa, but ParaFlo^® Bailenger performed significantly poorer than the Thebault method (p < 0.001). No statistical differences were observed between the commercial and in-house methods for helminth detection. These marketed concentration methods could be used in routine if combined with other techniques for protozoa detection. Full article

Snakebite being a quick progressing serious situation needs immediate and aggressive therapy. Snake venom antiserum is the only approved and effective treatment available, but for selected snake species only. The requirement of trained staff for administration and serum reactions make the therapy complicated. In tropical countries where snakebite incidence is high and healthcare facilities are limited, mortality and morbidities associated with snake envenomation are proportionately high. Traditional compilations of medical practitioners’ personal journals have wealth of plant-based snake venom antidotes. Relatively, very few plants or their extractives have been scientifically investigated for neutralization of snake venom or its components. None of these investigations presents enough evidence to initiate clinical testing of the agents. This review focuses on curating Indian traditional snake envenomation therapies, identifying plants involved and finding relevant evidence across modern literature to neutralize snake venom components. Traditional formulations, their method of preparation and dosing have been discussed along with the investigational approach in modern research and their possible outcomes. A safe and easily administrable small molecule of plant origin that would protect or limit the spread of venom and provide valuable time for the victim to reach the healthcare centre would be a great lifesaver. Full article

Patients with kidney failure (KF) have a high incidence of cardiovascular (CV) disease, partly driven by insufficient clearance of uremic toxins. Recent investigations have questioned the accepted effects of adverse lipid profile and CV risk in uremic patients. Therefore, we related a panel of uremic toxins previously associated with CV morbidity/mortality to a full lipid profile in a large, tri-national, cross-sectional cohort. Total, high-density lipoprotein (HDL), non-HDL, low-density lipoprotein (LDL), and remnant cholesterol, as well as triglyceride, levels were associated with five uremic toxins in a cohort of 611 adult KF patients with adjustment for clinically relevant covariates and other patient-level variables. Univariate analyses revealed negative correlations of total, non-HDL, and LDL cholesterol with all investigated uremic toxins. Multivariate linear regression analyses confirmed independent, negative associations of phenylacetylglutamine with total, non-HDL, and LDL cholesterol, while indole-3 acetic acid associated with non-HDL and LDL cholesterol. Furthermore, trimethylamine-N-Oxide was independently and negatively associated with non-HDL cholesterol. Sensitivity analyses largely confirmed findings in the entire cohort. In conclusion, significant inverse associations between lipid profile and distinct uremic toxins in KF highlight the complexity of the uremic milieu, suggesting that not all uremic toxin interactions with conventional CV risk markers may be pathogenic. Full article

In recent decades, there has been unprecedented development of hydropower in China, especially in the Yangtze River Basin, which has changed the hydrological and hydraulic conditions of natural rivers and has an impact on water quality. However, the spatial-–temporal extent, factors, and the reasons behind the influence of cascade hydropower development are not clear. The six hydropower stations on the main course of the middle reach of the Jinsha River in Yunnan and Sichuan Provinces have been in joint operation for seven years, and the impact of cascade hydropower development on water quality has begun to appear. In this paper, in order to accurately determine the causal relationship between cascade hydropower development and water quality changes on the middle reaches of the Jinsha River and their trends using regression discontinuity analysis, we collected monitoring data on water quality from 2004 to 2019. The results show that cascade hydropower development on the middle reach of the Jinsha River led to a decrease in TP concentration in that section of the river and an increase in the concentration of COD_Mn and NH₃-N. Furthermore, increase in sedimentation following the impoundment of cascade hydropower development is the main reason for the decrease in TP concentration, and the regional economic and social development driven by cascade hydropower development are external sources of the increase in the concentration of COD_Mn and NH₃-N. In addition, influenced by rainfall, the concentrations of COD_Mn and TP are higher in the rainy season and lower in the dry season, which is directly related to the input of non-point-source pollutants in the basin during the former. This study established a model to accurately judge the causal relationship between cascade hydropower development and water quality changes in the basin, which was then used to assess the impact of cascade hydropower development on water quality. Our results provide a basis for the formulation and implementation of a water quality protection plan for the middle reach of the Jinsha River and can also provide a basis for the development of cascade hydropower in other river basins. Full article

We studied the mineralization and sulfur isotopic composition of sulfides of gold–palladium ores in olivine clinopyroxenites from the Dzelyatyshor massif made up of a continuous layered series of rocks: olivine-free clinopyroxenite–olivine clinopyroxenite–wehrlite. The primary igneous layering of rocks, manifested as different quantitative ratios of clinopyroxene and olivine in them, controls the local trends of variability in the chemistry of mineral-forming medium and the concentrations of ore components, including noble metals, and sulfur in each separate layer during its cooling. The replacement of primary rock-forming minerals by secondary minerals, when the temperature decreases, is a characteristic trend for pyroxenites: (a) olivine → serpentine, secondary magnetite, and (b) clinopyroxene → amphibole, secondary magnetite → chlorite. The deposition of native gold in parageneses with PGM and sulfides at the Ozernoe occurrence took place during the replacement of earlier rock-forming minerals by chlorite. This process completed mineral formation at the deposit and took place at temperatures 150–250 °С and at the high activity of S, Te, Sb, and As of fluid. The variability of mineral formation conditions during chloritization is reflected in the change of native-sulfide forms of Pd by arsenide-antimonide forms and the sulfur isotopic composition of sulfides. The Pd content in native gold increases in the series—Au-Ag solid solution (<1.5 wt.% Pd)—Au-Cu intermetallides (to 6 wt.% Pd)—Cu-Au-Pd solid solutions (16.2–16.9 wt.% Pd). The sulfur isotopic composition of pyrite, chalcopyrite, and bornite varies from −2.1 to −2.9‰. It is assumed that a deep-seated magmatic basic melt was the source of fluid, ore components, and sulfur. Full article

Constipation is a common problem in sows and women during late pregnancy. Dietary fiber has potential in the regulation of intestinal microbiota, thereby promoting intestinal motility and reducing constipation. However, the effects of fibers with different physicochemical properties on intestinal microbe and constipation during late pregnancy have not been fully explored. In this study, a total of 80 sows were randomly allocated to control and one of three dietary fiber treatments from day 85 of gestation to delivery: LIG (lignocellulose), PRS (resistant starch), and KON (konjaku flour). Results showed that the defecation frequency and fecal consistency scores were highest in PRS. PRS and KON significantly increased the level of gut motility regulatory factors, 5-hydroxytryptamine (5-HT), motilin (MTL), and acetylcholinesterase (AChE) in serum. Moreover, PRS and KON promoted the IL-10 level and reduced the TNF-α level in serum. Furthermore, maternal PRS and KON supplementation significantly reduced the number of stillborn piglets. Microbial sequencing analysis showed that PRS and KON increased short-chain fatty acids (SCFAs)-producing genera Bacteroides and Parabacteroides and decreased the abundance of endotoxin-producing bacteria Desulfovibrio and Oscillibacter in feces. Moreover, the relative abundance of Turicibacter and the fecal butyrate concentration in PRS were the highest. Correlation analysis further revealed that the defecation frequency and serum 5-HT were positively correlated with Turicibacter and butyrate. In conclusion, PRS is the best fiber source for promoting gut motility, which was associated with increased levels of 5-HT under specific bacteria Turicibacter and butyrate stimulation, thereby relieving constipation. Our findings provide a reference for dietary fiber selection to improve intestinal motility in late pregnant mothers. Full article

Exosomes are membranous structures secreted by nearly all cell types. As critical messengers for intercellular communication, exosomes deliver bioactive cargoes to recipient cells and are involved in multiple physiopathological processes, including immunoregulation. Our pioneering study revealed that cancer cells release programmed death-ligand 1-positive exosomes into the circulation to counter antitumor immunity systemically via T cells. Tumor cell-derived exosomes (TDEs) also play an immunosuppressive role in other immunocytes, including dendritic cells (DCs), macrophages, natural killer (NK) cells, and myeloid-derived suppressor cells (MDSCs). Moreover, exosomes secreted by nontumor cells in the tumor microenvironments (TMEs) also exert immunosuppressive effects. This review systematically provides a summary of the immunosuppression induced by exosomes in tumor microenvironments, which modulates tumor growth, invasion, metastasis, and immunotherapeutic resistance. Additionally, therapeutic strategies targeting the molecular mechanism of exosome-mediated tumor development, which may help overcome several obstacles, such as immune tolerance in oncotherapy, are also discussed. Detailed knowledge of the specific functions of exosomes in antitumor immunity may contribute to the development of innovative treatments. Full article

Tick-borne pathogens (TBPs) include a wide range of bacteria, parasites and viruses that cause a large spectrum of animal, human and zoonotic tick-borne diseases (TBDs). The object of this review was to establish an inventory and an analysis of TBPs found in domestic animals in the countries of the Mediterranean Basin. This geographic area occupies a central position between several continents and is an area of movement for animals, humans and pathogens of interest and their vectors, which is important in terms of animal and human health. In this systematic review, we included a total of 271 publications produced between 2000–2021 concerning TBPs in domestic animals. Among this literature, we found a total of 90 pathogen species (known as TBPs) reported in the 20 countries of the area; these were detected in tick species from domestic animals and were also directly detected in domestic animals. In all, 31 tick species were recorded and 12 domestic animal species, the latter comprising nine livestock and three pet species. More than 50% of the publications were from Western Europe. Island data were extracted and assessed, as islands of the Mediterranean Basin were represented in 16% of the publications and 77.8% of the TBPs reported. Our results show the importance of islands in the monitoring of TBPs, despite the low percentage of publications. Full article

Background: The rise of multi-drug-resistant pathogens and nosocomial infections among hospitalized patients is partially attributed to the increased use of antibiotic therapy. A prediction model for in-hospital antibiotic treatment could be valuable to target preventive strategies. Methods: This was a retrospective cohort study, including patients admitted in 2018 to medical departments and not treated with antibiotics during the first 48 h. Data available at hospital admission were used to develop a logistic model to predict the probability of antibiotic treatment during hospitalization. The performance of the model was evaluated in two independent validation cohorts. Results: In the derivation cohort, antibiotic treatment was initiated in 454 (8.1%) out of 5592 included patients. Male gender, lower functional capacity, prophylactic antibiotic treatment, medical history of atrial fibrillation, peripheral vascular disease, solid organ transplantation, chronic use of a central venous catheter, urinary catheter and nasogastric tube, albumin level, mental status and vital signs at presentation were identified as predictors for antibiotic use during hospitalization and were included in the prediction model. The area under the ROC curve (AUROC) was 0.72 (95% CI 0.70-0.75). In the highest probability group, the percentage of antibiotic treatment was 18.2% (238/1,307). In the validation cohorts, the AUROC was 0.73 (95% CI 0.68-0.77) and 0.75 (95% CI 0.72-0.78). In the highest probability group, the percentage of antibiotic treatment was 12.5% (66/526) and 20.7% (244/1179) of patients. Conclusions: Our prediction model performed well in the validation cohorts and was able to identify a subgroup of patients at high risk for antibiotic treatment. Full article

Water pollution remains one of the greatest challenges in the modern era, and water treatment strategies have continually been improved to meet the increasing demand for safe water. In the last few decades, tremendous research has been carried out toward developing selective and efficient polymeric adsorbents and membranes. However, developing non-toxic, biocompatible, cost-effective, and efficient polymeric nanocomposites is still being explored. In polymer nanocomposites, nanofillers and/or nanoparticles are dispersed in polymeric matrices such as dendrimer, cellulose, resins, etc., to improve their mechanical, thermophysical, and physicochemical properties. Several techniques can be used to develop polymer nanocomposites, and the most prevalent methods include mixing, melt-mixing, in-situ polymerization, electrospinning, and selective laser sintering techniques. Emerging technologies for polymer nanocomposite development include selective laser sintering and microwave-assisted techniques, proffering solutions to aggregation challenges and other morphological defects. Available and emerging techniques aim to produce efficient, durable, and cost-effective polymer nanocomposites with uniform dispersion and minimal defects. Polymer nanocomposites are utilized as filtering membranes and adsorbents to remove chemical contaminants from aqueous media. This study covers the synthesis and usage of various polymeric nanocomposites in water treatment, as well as the major criteria that influence their performance, and highlights challenges and considerations for future research. Full article

In the north of China, during winter, a large number of activities (such as leisure, work, sightseeing and sports) are engaged in. This paper mainly focuses on human thermal perceptions of outdoor activities in a winter climate, especially the change in thermal perceptions when humans enter a temporary rest space with a shelter effect. A climate chamber was applied in our experiments, and temperature up-steps of 4, 8 and 12 °C were set, respectively. Twenty four college students were invited to engage in activities of different intensities, such as standing, walking (slowly) and biking. Through questionnaire survey and field measurement, the subjects’ thermal sensation, thermal comfort and skin temperature were obtained. Hypothesis testing and non-linear regression methods were introduced to analyze experiment data. Major results were as follows. After temperature up-step changes, thermal sensation and skin temperature reach steady state within 30 min. However, the change in skin temperature caused by a short-term thermal experience does not disappear completely within 40 min. In addition to the influence of ambient temperature changes, activity intensity also influenced the variation in thermal sensation (subjective) and skin temperature (objective). These study results provide a scientific reference for future research and design of a temporary rest space in low ambient temperatures. Experimental studies including broader age groups and outdoor field tests are valuable for future research. Full article

Regular physical activity from an early age is an important part of a healthy life because if we incorporate exercise early into our lifestyle, we are more likely to maintain our commitment to sport into adulthood and even throughout our lives. In our research, we used the PERSIST 2019 database, which contains data from students at higher education institutions in Hungary, Slovakia, Romania, Ukraine, and Serbia. We used factor analysis to isolate four sports motivation factors (intrinsic, introjected, extrinsic, and amotivation). Factors influencing the different types were measured using linear regression analysis, involving the variables in four models. The results show that the effects of the sociodemographic variables are significant for gender, country, and mother’s job, especially in terms of intrinsic, introjected, and extrinsic motivation. The role of coping is salient for health awareness factors, with a positive effect on intrinsic motivation and a negative effect on the other types. The impacts of quality of education and support are typically negative, while the positive effect of satisfaction with infrastructure is noteworthy. The effect of persistence in sport on intrinsic and introjected motivation is positive. Frequency of training increases intrinsic motivation, while practical sport embeddedness generates extrinsic motivation. In terms of relationships, a mainly teacher-oriented network within the institution typically has a negative effect on intrinsic motivation, while peer relationships outside the institution typically increase intrinsic and extrinsic sport motivation. Academic persistence has a positive effect on intrinsic motivation and a negative effect on introjected motivation. Our research highlights the complexity of factors influencing sport motivation and the role of coping, which typically remains strong when relationship-related variables are included. In addition, we must emphasise the dominant role of relationship network patterns, which may even reduce commitment to sport. Full article

To deliver therapeutic proteins into a living body, it is important to maintain their target activity in the gastrointestinal tract after oral administration. Secreted ribonuclease from Bacillus pumilus (binase) has antitumor and antiviral activity, which makes it a promising therapeutic agent. This globular protein of small molecular weight (12.2 kDa) is considered as a potential agent that induces apoptosis of tumor cells expressing certain oncogenes, including colorectal and duodenum cancer. The most important problem of its usage is the preservation of its structure and target activity, which could be lost during oral administration. Here, we developed alginate microspheres reinforced with divalent cations and analyzed the enzyme release from them. Using methods of scanning electron microscopy, measurements of fluorescence, enzyme catalytic activity, and determination of viability of the duodenum adenocarcinoma tumor cell line, we characterized obtained microspheres and chose calcium as a biogenic ion-strengthening microsphere structure. Among such modified additivities as beta-casein, gelatin, and carbon nanotubes introduced into microspheres, only gelatin showed a pronounced increase in their stability and provided data on the prolonged action of enzyme release from microspheres into tumor cell culture medium during 48 h in an amount of about 70% of the loaded quantity. Full article

The prognostic significance of bone marrow fibrosis (MF) grade in patients with myelodysplastic syndrome (MDS) is still debated and the molecular changes remain unclear. In our large cohort, a normal reticulum was found in 211 (25.9%) patients, whereas MF1, MF2 and MF3 were detected in 478 (58.7%), 90 (11.1%) and 35 (4.3%) patients at initial diagnosis, respectively. Patients with MF often correlated with some poor prognostic characteristics, including older age, anemia, unfavorable karyotype, higher BM blast and a higher IPSS-R category. For the entire cohort, the median OS was not reached, 30, 16 and 15 months for patients with MF 0, 1, 2 and 3, respectively. After adjusting for IPSS-R, the hazard ratio for mortality was 1.56 (95% CI, 1.18–2.06) for patients with MF1, 2.29 (95% CI, 1.61–3.27) for patients with MF2 and 2.75 (95% CI, 1.69–4.49) for patients with MF3 compared with those with MF0. The mutational landscape of 370 patients showed that TP53, U2AF1 and KMT2D mutations were more frequent in patients with MF2-3. In addition, of the 408 patients with MF0-1, 62 patients (15.1%) progressed to MF2-3 during the follow-up interval. The clinical features, mutation landscape and prognosis of patients with progressed fibrosis were similar to those of patients with MF2-3 at diagnosis. We concluded that BM fibrosis (MF1, 2 and 3) was an adverse prognosis feature in primary MDS and correlated with TP53 mutations both at the time of initial diagnosis and during the course of the disease. Therefore, BM fibrosis should be included in the revised prognostic scoring system and carefully considered in treatment selection. Full article

The RF-driven negative ion source has a steady state characteristic and will be a promising ion source for neutral beam injection (NBI) in the future. Cesium (Cs) injection is an efficient method to enhance the yield of negative ions during plasma discharge. In order to support the engineering and physical research in this field, the Cs oven prototype has been developed for negative ion source based neutral beam injector at ASIPP. This article presents the design details of a Cs oven system, including the constant temperature control system, the mechanical structure of Cs oven, and the surface ionization detector (SID). SID is a measurement method for the cesium flux in the nozzle. The experiment results of constant temperature control system show that the control accuracy and function meet the requirements of device operation. Meanwhile, the simulation analysis of Cs vapor concentration has been carried out in this paper. According to the simulation results, the graph of total Cs flux is given in the article, which presents the reference for the subsequent device testing. Full article

Distance measures in ordered weighted averaging (OWA) operators allow the modelling of complex decision making problems where a set of ideal values or characteristics are required to be met. The objective of this paper is to introduce extended distance measures and logarithmic OWA-based decision making operators especially designed for the analysis of financial investment options. Based on the immediate weights, Bonferroni means and logarithmic averaging operators, in this paper we introduce the immediate weights logarithmic distance (IWLD), the immediate weights ordered weighted logarithmic averaging distance (IWOWLAD), the hybrid weighted logarithmic distance (HWLD), the Bonferroni ordered weighted logarithmic averaging distance (B-OWLAD) operator, the Bonferroni immediate weights ordered weighted logarithmic averaging distance (B-IWOWLAD) operator and the Bonferroni hybrid weighted logarithmic distance (HWLD). A financial decision making illustrative example is proposed, and the main benefits of the characteristic design of the introduced operators is shown, which include the analysis of the interrelation between the modelled arguments required from the decision makers and the stakeholders, and the comparison to an ideal set of characteristics that the possible companies in the example must portray. Moreover, some families, particular cases and brief examples of the proposed operators, are studied and presented. Finally, among the main advantages are the modeling of diverse perspectives, attitudinal characteristics and complex scenarios, through the interrelation and comparison between the elements with an ideal set of characteristics given by the decision makers and a set of options. Full article

The water–energy nexus has become a key factor in the implementation of low-carbon green development, which has led to the need for exploring effective management within the coupled integrated system with multi-energy flow supplies. In this study, the coupled relationship between water resources and energy in the integrated energy system was systematically analyzed, and a system operation optimization model was proposed through comprehensively considering cold, heat and electricity load, and nine kinds of energy conversion and supply equipment/technology from the perspective of a water resources and energy nexus in a typical industry park. The system operation scheme, energy supply mode, net benefit and water resource consumption under different water resource control scenarios were obtained. The results show that water resource control would directly bring about a directly positive influence on renewable energy utilization and energy storage reduction, and that a system’s external dependence and benefits, renewable energy utilization potential and other factors in an integrated energy system should be comprehensively considered. The development of more effective control indicators could be better to promote the effectiveness of bidirectional regulation in a water–energy nexus. Full article

Nanofluids based on vegetable oil have emerged as ecological alternatives to conventional cutting fluids. Jojoba-seed oil has recently been identified as adequate for use in metal cutting. Aiming to assess the stability and thermophysical properties of jojoba nanofluids, this article reports an experiment- and modelling-based investigation. The stability, viscosity and thermal conductivity of jojoba MoS₂ nanofluid were studied across a broad range of temperatures and concentrations of nanoparticles. The functional relationship of the viscosity and thermal conductivity to the temperature and concentration was determined by regression analysis. In addition to confirming known phenomena, vis-à-vis the effect of the concentration and temperature on the viscosity and thermal conductivity, this study shows that the increase in the thermal conductivity in line with the concentration stagnates after an initial sharp rise due to an increase in the attractive forces between the particles. The viscosity displays a second-order interactive relationship with the temperature and concentration of the nanoparticles, whereas thermal conductivity follows a complex third-order interaction model. In addition to being economical, jojoba nanofluid matches or surpasses the nanofluid prepared using commercially available mineral-oil-based cutting fluid (LRT 30)—which is specially designed for the minimum-quantity lubrication method of metal cutting. Conclusively, this investigation paves the way for the shop-floor application of jojoba nanofluid in metal-cutting operations. Full article

Many patients with upper limb defects desire myoelectric prosthetic hands, but they are still not used for some reasons. One of the most significant reasons is its external appearance, which has the discomfort caused by the structural difference between a human hand and a robotic link. The structure must be based on human anatomy to create a more natural-looking prosthesis. This study designed a biomimetic prosthetic hand with bones, ligaments, tendons, and multiple muscles based on the human musculoskeletal system. We verified the proposed prosthetic hand using the viscoelastic angle sensor to determine whether it works like a human hand. We also compared the finger force of the prosthetic hand with that of a human finger. It could be capable of controlling the angle and the stiffness of the joint by multiple extensor and flexor muscles, like humans. Full article