The fragment antigen-binding (Fab) fragment is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. The variable domain contains the paratope (the antigen-binding site), comprising a set of complementarity determining regions, at the amino terminal end of the monomer. Each arm of the Y thus binds an epitope on the antigen.
In an experimental setting, Fc and Fab fragments can be generated in the laboratory. The enzyme papain can be used to cleave an immunoglobulin monomer into two Fab fragments and an Fc fragment. The enzyme pepsin cleaves below hinge region, so a F(ab')2 fragment and a pFc' fragment is formed. Recently another enzyme for generation of F(ab')2 has been commercially available. The enzyme IdeS (Immunoglobulin degrading enzyme from Streptococcus pyogenes, trade name FabRICATOR) cleaves IgG in a sequence specific manner at neutral pH. The F(ab')2 fragment can be split into two Fab' fragments by mild reduction.
Fab is an e-commerce company founded in 2010. Once estimated at a worth of over 1 billion dollars, in November 2014, the company was rumored to be in talks to sell for 15 million. In March 2015, PCH International acquired Fab for an undisclosed sum.
It grew from 175,000 members in June 2011, to over 10 million as of December 2012. As of April 30, 2013, Fab has disclosed that it receives 6 million unique visitors per month and have sold over 7 million products since launch. Fab is headquartered in Manhattan and operates a warehouse in Keasbey, New Jersey. The company has office locations in NYC, Pune (India), and Berlin.
Fab was founded in February 2010 by Jason Goldberg (entrepreneur) (formerly of XING AG and Jobster) and chief designer Bradford Shellhammer. The site was originally created as a social network for gay men and their friends before pivoting on June 9, 2011 into its model of daily design inspirations and sales. In November 2011, five months after re-launching, Fab reached 1 million members. The company reached this number faster than Facebook, Twitter and Groupon. In September 2012, Fab removed the membership requirements to browse the site. In December 2012, Fab passed 10 million members, up from 7.5 million members in September. Fab also announced it had sold more than 4.3 million products since its launch, averaging 5.4 products sold per minute. In July 2013, fab eliminated 100 positions at its Berlin office as a profit-building measure. Fab laid off 101 more staff, primarily at its New York office in October 2013, further reducing their workforce by 19 percent.
Fab Five may refer to:
"Heaven" is a song recorded by American rapper Jay-Z from his twelfth studio album Magna Carta Holy Grail (2013) featuring American recording artist Justin Timberlake. The song was written by Jay-Z, The-Dream, members of R.E.M., Adrian Younge, Timbaland, and Jerome "J-Roc" Harmon while the production was handled by the latter two. During the song, Jay-Z touches on subjects of religious allegory and an interrogation of organized religion. The song has since peaked at number 10 on the Billboard Bubbling Under Hot 100 Singles.
On "Heaven", Jay-Z questions the meaning of religion and once again shoots down rumors that he is part of the secret organization Illuminati. He explained the song in a promotional video for Samsung saying,
The song indulges in religious allegory, and is one of the few songs on Magna Carta Holy Grail that touch upon existential and spiritual themes. Throughout the song he ponders faith, superstition and free thinking.
The songs features Jay-Z rapping a lyric of rock band, R.E.M.'s 1991 single "Losing My Religion". Following the album's release, former frontman of R.E.M. Michael Stipe told NME that he's "thrilled" and it was a "great honor", that Jay-Z included the lyrics in one of his songs.
Heaven is a heavy metal band from Sydney, Australia that formed in 1980. The band recorded three albums and toured throughout the United States during the 1980s. The group's original style was similar to that of AC/DC but in later years went in a more commercial heavy metal direction along the lines of Judas Priest.
The band was originally formed in Adelaide under the name Fat Lip, which featured Scottish-born Allan Fryer, bassist Laurie Marlow, formerly of Almost Human, and drummer Joe Turtur. Soon after the band moved to Sydney, AC/DC singer Bon Scott died in London and some unsubstantiated reports suggested that band was considering Fryer as a replacement. Fryer left Fat Lip and returned to Adelaide but he was never called upon to audition. Once back in Sydney, Fat Lip now consisted of Fryer and Marlow, Aldo Civitico (ex-Scandal) on drums and guitarist Bradford Kelly, formerly of John Swan's band Swanee. Civitico dropped out just before the band signed its record deal, and was replaced briefly by Theo Kats, who himself soon left to join a band called Europe, and Turtur returned to the group. John Haese was also added as rhythm guitarist. Shortly afterward, Fat Lip came to the attention of Michael Browning, a Sydney music industry figure who had managed AC/DC in the 1970s and had just started a new record label called DeLuxe, to which he had signed INXS. Fat Lip began recording an album for DeLuxe, but changed its name to Heaven during the sessions. The album, Twilight of Mischief, was preceded in late 1981 by a single, "Fantasy". A second single, "In the Beginning" became the album's title track when it was released by RCA in the US under that name.
"Heaven" is the title of a popular song from 2004 by the American Tejano/Chicano rock band Los Lonely Boys. The song was written by brothers Henry, Jojo and Ringo Garza, who comprise the foundation of the band, and it appears on their multi-platinum self-titled album.
Released as a single in mid-2004, "Heaven" reached the Top 40 on the U.S. Billboard Hot 100 chart, peaking at 16 in August. Later that year, the song began a sixteen week run at number 1 on the Billboard Adult Contemporary chart in October. It was also a minor hit at country radio, where it peaked at number 46.
AllMusic reviewer Thom Jurek describes the song as "infectious" and draws comparisons to the music of Freddie King, Stevie Ray Vaughan and Los Lobos. He states that "Heaven" is "a single in the old sense of the word: killer hook, easy groove, a slippery but unmistakable bridge with a beautiful vocal to boot -- all coming in under four minutes."
The success of "Heaven" led to two Grammy Award nominations and one win for the band at the 47th Grammy Awards, held in early 2005. The song won in the category Best Pop Performance by a Duo group, while Los Lonely Boys were nominated in the category Best New Artist, losing out to Maroon 5.