MobileMe
MobileMe (formerly .Mac and iTools) was a subscription-based collection of online services and software offered by Apple Inc. All services were being gradually transitioned and replaced by iCloud and the service ceased as of June 30, 2012, with transfers to iCloud available until July 31, 2012. Afterwards, all data was deleted, and the email addresses of accounts not transferred to iCloud were marked as unused.
An early attempt by Apple with online services was eWorld, which ran from June 1994 until March 1996.
Originally launched on January 5, 2000, as iTools, a free collection of Internet-based services for users of Mac OS 9, Apple relaunched it as .Mac on July 17, 2002, when it became a paid subscription service primarily designed for users of Mac OS X. Apple relaunched the service again as MobileMe on July 9, 2008 at the Apple Worldwide Developers Conference (WWDC) 2008, now targeting Mac OS X, Microsoft Windows, iPhone, iPod touch and iPad users.
On February 24, 2011, Apple discontinued offering MobileMe at its retail stores, with MobileMe retail boxes eventually removed from resellers as well. Additionally, Apple stopped accepting new subscriptions for MobileMe. On June 6, 2011, Apple announced that a new service called iCloud would replace MobileMe sometime in the fall. At the iPhone 4S special event on October 4, 2011, Apple announced it would finally launch iCloud on October 12, 2011, to replace MobileMe for new users, with current users having access until June 30, 2012 (on that day the service would cease).
Cindy "Mac" Mackenzie
Cindy "Mac" Mackenzie is a fictional character on UPN/The CW television series Veronica Mars played by Tina Majorino. She was a recurring character during the first two seasons, and turned into a regular character for the third season.
Mac uses her computer hacking and cracking skills to help Veronica with her cases; the two joke that she is a kind of Q to Veronica's James Bond. Coincidentally or not, Mac (a common nickname for "Mackenzie") has shown preference for Apple Macintosh computers, which share her nickname.
Background
In the episode where Mac is introduced, "Like a Virgin", she helps Veronica find out who has stolen her password and has created a false score under her name on a purity test that had become a brief fad at Neptune High. However, Mac is the person who created the test in the first place, making it possible for the "sex crazed 09ers" to access other people's purity tests. Veronica has no resentment towards Mac for this, only caring about those that took tests for others.
List of It's Always Sunny in Philadelphia characters
The following is a list of recurring characters from the FX television series It's Always Sunny in Philadelphia.
The Gang
Charlie Kelly
Charlie is a former co-owner at Paddy's and a childhood friend of Mac and Dennis. Frank is his roommate and possible biological father. Charlie is the janitor at the pub, and an illiterate, alcoholic and vapors huffer, who suffers from deep psychological problems, and has anger management issues, and often screams to get his point across. He lives in squalor. Charlie's intentions are often pure, but his plans are almost always foiled. He is played by Charlie Day.
Ronald "Mac" McDonald
Ronald "Mac" McDonald is Charlie Kelly's childhood friend and Dennis's high school friend and later roommate. He is a co-owner of Paddy's and its bouncer. He brags about his incredible hand-to-hand combat skills, strength, and general athletic ability though it is quite obvious he lacks any real skill or even a proper sense of balance. His full name is revealed to be Ronald McDonald in the seventh season episode "The High School Reunion", though his last name involving "Mac" had been established since the introduction of his father. Mac and Dennis share an odd relationship that is highlighted in the later seasons. It is obvious to everyone on the show's universe except Mac that he is gay, and that he is only in denial about it because of his unbending pre-Vatican II Catholicism. He is played by Rob McElhenney.
68–95–99.7 rule
In statistics, the so-called 68–95–99.7 rule is a shorthand used to remember the percentage of values that lie within a band around the mean in a normal distribution with a width of one, two and three standard deviations, respectively; more accurately, 68.27%, 95.45% and 99.73% of the values lie within one, two and three standard deviations of the mean, respectively. In mathematical notation, these facts can be expressed as follows, where x is an observation from a normally distributed random variable, μ is the mean of the distribution, and σ is its standard deviation:
In the empirical sciences the so-called three-sigma rule of thumb expresses a conventional heuristic that "nearly all" values are taken to lie within three standard deviations of the mean, i.e. that it is empirically useful to treat 99.7% probability as "near certainty". The usefulness of this heuristic of course depends significantly on the question under consideration, and there are other conventions, e.g. in the social sciences a result may be considered "significant" if its confidence level is of the order of a two-sigma effect (95%), while in particle physics, there is a convention of a five-sigma effect (99.99994% confidence) being required to qualify as a "discovery".
Sigma Seven
Sigma Seven Co., Ltd. (株式会社シグマ・セブン, Kabushiki-gaisha Shiguma Sebun) is a Japanese talent management firm representing a fair number of voice actors and entertainers. Founded on March 3, 1988, Sigma Seven is headquartered on the third floor of the Haga Building in Minato, Tokyo, Japan.
Notable voice actors
Female
Male
References
External links
Sigma-1 receptor
The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. In humans, the σ1 receptor is encoded by the SIGMAR1 gene.
The σ1 receptor is a transmembrane protein expressed in many different tissue types. It is particularly concentrated in certain regions of the central nervous system. It has been implicated in myriad phenomena, including cardiovascular function, schizophrenia, clinical depression, the effects of cocaine abuse, and cancer. Much is known about the binding affinity of hundreds of synthetic compounds to the σ1 receptor.
An endogenous ligand for the σ1 receptor has yet to be conclusively identified, but tryptaminergic trace amines, as well as neuroactive steroids such as dehydroepiandrosterone (DHEA) and pregnenolone all activate the receptor.
Characteristics
The σ1 receptor is defined by its unique pharmacological profile. In 1976 Martin reported that the effects of N-allylnormetazocine (SKF-10,047) could not be due to activity at the μ and κ receptors (named from the first letter of their selective ligands morphine and ketazocine, respectively) and a new type of opioid receptor was proposed; σ (from the first letter of SKF-10,047). However, ligands acting at this new “opioid” receptor were not blocked by the classical opioid antagonists naloxone and naltrexone. Consequently, the opioid classification was eventually dropped and the receptor was later termed the σ1 receptor. It was found to have affinity for the (+)-stereoisomers of several benzomorphans (e.g., (+)-pentazocine and (+)-cyclazocine), various structurally and pharmacologically distinct psychoactive chemicals such as haloperidol and cocaine, and neuroactive steroids like progesterone.
Book of Genesis
The Book of Genesis (from the Latin Vulgate, in turn borrowed or transliterated from Greek γένεσις, meaning "origin"; Hebrew: בְּרֵאשִׁית, Bərēšīṯ, "In [the] beginning") is the first book of the Hebrew Bible (the Tanakh) and the Christian Old Testament.
The basic narrative expresses the central theme: God creates the world (along with creating the first man and woman) and appoints man as his regent, but man proves disobedient and God destroys his world through the Flood. The new post-Flood world is equally corrupt, but God does not destroy it, instead calling one man, Abraham, to be the seed of its salvation. At God's command Abraham descends from his home into the land of Canaan, given to him by God, where he dwells as a sojourner, as does his son Isaac and his grandson Jacob. Jacob's name is changed to Israel, and through the agency of his son Joseph, the children of Israel descend into Egypt, 70 people in all with their households, and God promises them a future of greatness. Genesis ends with Israel in Egypt, ready for the coming of Moses and the Exodus. The narrative is punctuated by a series of covenants with God, successively narrowing in scope from all mankind (the covenant with Noah) to a special relationship with one people alone (Abraham and his descendants through Isaac and Jacob).
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