The Sandman is a mythical character in central and northern European folklore who puts people to sleep and brings good dreams by sprinkling magical sand onto the eyes of people while they sleep at night.
Traditionally, he is a character in many children's stories. He is said to sprinkle sand or dust on or into the eyes of the child at night to bring on dreams and sleep. The grit or "sleep" in one's eyes upon waking is supposed to be the result of the Sandman's work the previous evening.
Hans Christian Andersen's 1841 folk tale Ole Lukøje introduced the Sandman, named Ole Lukøje, by relating dreams he gave to a young boy in a week through his magical technique of sprinkling dust in the eyes of the children. "Ole" is a Danish name and "Lukøje" means "close eye". Andersen wrote:
E. T. A. Hoffmann (1776–1822) wrote an inverse depiction of the lovable character in a story called Der Sandmann, which showed how sinister such a character could be made. According to the protagonist's nurse, he threw sand in the eyes of children who wouldn't sleep, with the result of those eyes falling out and being collected by the Sandman, who then takes the eyes to his iron nest on the Moon, and uses them to feed his children. The protagonist of the story grows to associate this nightmarish creature with the genuinely sinister figure of his father's associate Coppelius. In Romanian folklore there is a similar character, Mos Ene (Ene the Elder).
America is the eponymous debut album by America, released in 1971. It was initially released without "A Horse with No Name", which was released as a single in late 1971. When "Horse" became a worldwide hit in early 1972, the album was re-released with that track.
The album went to #1 on the Billboard album chart in the US and stayed there for five weeks. It produced two hit singles; "A Horse with No Name" spent three weeks at #1 on the Billboard singles chart in 1972 (it peaked at #3 on the Adult Contemporary chart), and "I Need You" hit #9 on the Billboard singles chart and #7 on the AC chart. Several other songs received radio airplay on FM stations playing album tracks, including "Sandman" (long rumoured in the US Navy to be about the VQ-2 air squadron formerly based in Rota, Spain) and "Three Roses". The album was certified platinum by the RIAA for sales in excess of one million units in the US.
In his Allmusic review music critic David Cleary called the band's debut album a "folk-pop classic" and concluded, "In spite of its flaws, this platter is very highly recommended."
Logan's Run is a novel by William F. Nolan and George Clayton Johnson. Published in 1967, it depicts a dystopic ageist future society in which both population and the consumption of resources are maintained in equilibrium by requiring the death of everyone reaching a particular age. The story follows the actions of Logan, a Sandman charged with enforcing the rule, as he tracks down and kills citizens who "run" from society's lethal demand—only to end up "running" himself.
The introduction to the book states:
In the world of 2116, a person's maximum age is strictly legislated: twenty one years, to the day. When people reach this Lastday they report to a Sleepshop in which they are willingly executed via a pleasure-inducing toxic gas. A person's age is revealed by their palm flower crystal embedded in the palm of their right hand that changes color every seven years, yellow (age 0-6), then blue (age 7-13), then red (age 14-20), then blinks red and black on Lastday, and finally turns black at 21.
Autosave is a function in many computer applications or programs which saves an opened document automatically, helping to reduce the risk or impact of data loss in case of a crash or freeze. Autosaving is typically done either in predetermined intervals or before a complex editing task is begun.
It has traditionally been seen as a feature to protect documents in an application or system failure (crash), and autosave backups are often purged whenever the user finishes his or her work. An alternative paradigm is to have all changes saved continuously (as with pen and paper) and all versions of a document available for review. This would remove the need for saving documents entirely. There are challenges to implementation at the file, application and operating system levels.
For example, in Microsoft Excel 2003, this option is called AutoRecover and, by default, saves the document every ten minutes in the temporary file directory. Restarting Excel after crashing prompts the user to save the last recovered version. However, this does not protect users who mistakenly click "No" when asked to save their changes if Excel closes normally.
Allostery is the most direct and efficient way for regulation of biological macromolecule function induced by the binding of a ligand at an allosteric site topographically distinct from the orthosteric site. Due to the inherent high receptor selectivity and lower target-based toxicity, it is also expected to play a more positive role in drug discovery and bioengineering, leading to rapid growth on allosteric findings.
Allosteric Database (ASD) provides a central resource for the display, search and analysis of the structure, function and related annotation for allosteric molecules. Currently, ASD contains allosteric proteins from more than 100 species and modulators in three categories (activators, inhibitors, and regulators). Each protein is annotated with a detailed description of allostery, biological process and related diseases, and each modulator with binding affinity, physicochemical properties and therapeutic area. Integrating the information of allosteric proteins in ASD should allow for the prediction of allostery for unknown proteins and eventually make them ideal targets for experimental validation. In addition, modulators curated in ASD can be used to investigate potent allosteric targets for the query compound, and also help chemists implement structure modifications for novel allosteric drug designs. Therefore, ASD could be a platform and a starting point for biologists and medicinal chemists for furthering allosteric research.
ASD is the fifth album by American post-hardcore band A Skylit Drive, released on October 9, 2015, through Tragic Hero Records.
It's the first studio album without bassist and unclean vocalist, Brian White, and founding drummer and backing vocalist, Cory La Quay, who both left the band in 2014, respectively replaced by Michael Labelle and Brandon "Rage" Richter.
All lyrics written by Michael Jagmin, Nick Miller, Michael Labelle and Kit Walters, music by A Skylit Drive.