Hint

Hint and similar may refer to:

Uppercase

HINT2

Histidine triad nucleotide binding protein 2 (HINT2) is a mitochondrial protein that in humans is encoded by the HINT2 gene on chromosome 9. This protein is an AMP-lysine hydrolase and phosphoamidase and may contribute to tumor suppression.

Structure

As a member of the histidine triad nucleotide-binding (Hint) protein family, which is a subfamily of the histidine triad (HIT) family, HINT2 contains a conserved histidine and HIT sequence motif (His-X-His-X-His-X-X), and the latter two histidines contribute to a catalytic triad. The 163-amino acid protein encoded by this gene forms a 17-kDa homodimer. Compared to other members of the Hint family, HINT2 has a 61% sequence homology to HINT1 and 28% sequence homology to HINT3. When compared with HINT1, the 35–amino acid extension at the HINT2 N-terminal corresponds to a predicted mitochondria import signal.

Function

HINT1

Histidine triad nucleotide-binding protein 1 is a protein that in humans is encoded by the HINT1 gene. It is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and Microphthalmia-associated transcription factor (MITF) activity in human mast cells. In the LysRS-Ap4A-MITF signaling pathway, HINT1 inhibits the MITF transcriptional activity by direct association. Upon pathway activation, HINT1 is released from MITF by diadenosine tetraphosphate (Ap4A), produced by LysRS.

References

Further reading

Untitled (Selections from 12)

Untitled (Selections From 12) is a 1997 promotional-only EP from German band The Notwist which was released exclusively in the United States. Though the release of the EP was primarily to promote the band's then-current album 12, it contains one track from their 1992 second record Nook as well as the non-album cover of Robert Palmer's "Johnny and Mary". The version of "Torture Day" on this EP features the vocals of Cindy Dall.

Track listing

Untitled (Marc and the Mambas album)

Untitled is the first studio album by the British singer/songwriter Marc Almond's band Marc and the Mambas. It was released by Some Bizzare in September 1982.

Background

Untitled was Almond's first album away from Soft Cell and was made concurrently with the latter's The Art of Falling Apart album. Almond collaborated with a number of artists for this album, including Matt Johnson of The The and Anni Hogan. The album was produced by the band, with assistance from Stephen Short (credited as Steeve Short) and Flood.

Jeremy Reed writes in his biography of Almond, The Last Star, that Untitled was "cheap and starkly recorded". He states that Almond received "little support from Phonogram for the Mambas project, the corporate viewing it as non-commercial and a disquieting pointer to the inevitable split that would occur within Soft Cell". An article in Mojo noted that "from the beginning, Almond and Ball had nurtured sideline projects, though only the former's - the 1982 double 12 inch set Untitled - attracted much attention, most of it disapproving." The article mentions that Almond "who preferred to nail a song in one or two takes" stated that it was all "about feel and spontaneity, otherwise it gets too contrived" when accused of singing flat.<ref name"mojo">Paytress, Mark. "We Are The Village Sleaze Preservation Society". Mojo (September 2014): 69. </ref>

Untitled (West)

Untitled is an outdoor 1977 stainless steel sculpture by American artist Bruce West, installed in Portland, Oregon, in the United States.

Description

Bruce West's Untitled is installed along Southwest 6th Avenue between Washington and Stark streets in Portland's Transit Mall. It was one of eleven works chosen in 1977 to make the corridor "more people oriented and attractive" as part of the Portland Transit Mall Art Project. The stainless steel sculptures is 7 feet (2.1 m) tall. It was funded by TriMet and the United States Department of Transportation, and is administered by the Regional Arts & Culture Council.

See also

References

External links