We report the difference existing between two clinical syndromes: Spiller's syndrome is caused by... more We report the difference existing between two clinical syndromes: Spiller's syndrome is caused by a complete involvement of the medial hemimedulla, while Déjérine's syndrome is determined by lesions restricted to the anterior portion of the medial hemimedulla and is characterized by hypoglossal nerve palsy and contralateral hemiparesis.
We used RNA fingerprinting by arbitrary primed PCR to identify genes whose expression is up-regul... more We used RNA fingerprinting by arbitrary primed PCR to identify genes whose expression is up-regulated in the brain of hamsters affected by prion disease. One gene implicated by RNA fingerprinting encoded the hamster homologue of protein nexin-I (PN-I), a serine proteinase inhibitor, and was further investigated by Northern blot analysis. PN-I mRNA levels were increased at pre-clinical stages (19 days after inoculation) and remained elevated when the spongiform encephalopathy was anatomopathologically and clinically evident (at 50 and 80 days). Future RNA screening conducted as illustrated may help to reveal a spectrum of genes relevant for the etiopathogenesis and/or diagnosis of prion disease.
Various neurological disorders have been related to Streptococcus pyogenes infection. Only recent... more Various neurological disorders have been related to Streptococcus pyogenes infection. Only recently, and for the first time, it has been suggested that acute disseminated encephalitis may also complicate a streptococcal infection. The case reported in this paper seems to confirm this hypothesis. Varie malattie neurologiche possono essere associate ad infezioni da Streptococco pyogenes. Solo recentemente e per la prima volta à stato segnalato un caso di Encefalomielite Acuta Disseminata come complicanza di infezione Streptococcica. Il caso descritto in questo articolo sembra confermare la possibilità di tale complicazione.
We report the difference existing between two clinical syndromes: Spiller's syndrome is caused by... more We report the difference existing between two clinical syndromes: Spiller's syndrome is caused by a complete involvement of the medial hemimedulla, while Déjérine's syndrome is determined by lesions restricted to the anterior portion of the medial hemimedulla and is characterized by hypoglossal nerve palsy and contralateral hemiparesis.
We used RNA fingerprinting by arbitrary primed PCR to identify genes whose expression is up-regul... more We used RNA fingerprinting by arbitrary primed PCR to identify genes whose expression is up-regulated in the brain of hamsters affected by prion disease. One gene implicated by RNA fingerprinting encoded the hamster homologue of protein nexin-I (PN-I), a serine proteinase inhibitor, and was further investigated by Northern blot analysis. PN-I mRNA levels were increased at pre-clinical stages (19 days after inoculation) and remained elevated when the spongiform encephalopathy was anatomopathologically and clinically evident (at 50 and 80 days). Future RNA screening conducted as illustrated may help to reveal a spectrum of genes relevant for the etiopathogenesis and/or diagnosis of prion disease.
Various neurological disorders have been related to Streptococcus pyogenes infection. Only recent... more Various neurological disorders have been related to Streptococcus pyogenes infection. Only recently, and for the first time, it has been suggested that acute disseminated encephalitis may also complicate a streptococcal infection. The case reported in this paper seems to confirm this hypothesis. Varie malattie neurologiche possono essere associate ad infezioni da Streptococco pyogenes. Solo recentemente e per la prima volta à stato segnalato un caso di Encefalomielite Acuta Disseminata come complicanza di infezione Streptococcica. Il caso descritto in questo articolo sembra confermare la possibilità di tale complicazione.
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