A Genomewide Search for Quantitative-Trait Loci Underlying Asthma

Genomics, 1999

Asthma is among the most frequent chronic diseases in childhood. Although numerous environmental risk factors have already been identified, the basis for familial occurrence of asthma remains unclear. Previous genome screens for atopy in British/Australian families ...

2019

We carried out a genome-wide association study (GWAS) for asthma in UK Biobank, followed by a meta-analysis with results from the Trans-National Asthma Genetic Consortium (TAGC). 66 novel genomic regions were identified, bringing the number of known asthma susceptibility loci to 211. Significant gene-sex interactions were also observed where susceptibility alleles, either individually or as a function of polygenic risk scores, increased asthma risk to a greater extent in men than women. Bioinformatics analyses demonstrated that asthma-associated variants were enriched for colocalizing to regions of open chromatic in immune cells and identified candidate causal genes at 52 of the novel loci, including CD52. An anti-CD52 (α-CD52) antibody mimicked the immune cell-depleting effects of an FDA-approved human α-CD52 antibody and reduced allergen-induced airway hyperreactivity in mice. These results further elucidate the genetic architecture of asthma, provide evidence that the immune syst...

Human Molecular Genetics, 1999

RESPIRATORY RESEARCH, 2018

1998

2010

PLoS ONE, 2011

Academia Materials Science, 2023

Photocatalysis is an advanced oxidation method that allows, among other issues, the removal of aqueous pollutants of different origins. However, its application on an industrial scale is limited by the requirement of excitation sources in the UV frequency. For this reason, it is extremely important to develop photocatalytic materials capable of working under visible radiation in photodegradation processes. This paper analyzes the synthesis of TiO2 nanoparticles, using a new sol-gel effective route in a nonpolar dissolvent, and its modification by doping with different Chromium VI ions concentrations: 0.5; 1.0 and 1.5% w/w. In addition, a novel modification of this synthesis technique is reported, in which a nonpolar solvent, C6H12 is used to control, the hydrolysis reactions of the titania precursor. Similarly, the use of ammonium chromate, (NH4)2CrO4, introduced by means of the impregnation-by-moisture-incipient technique, is proposed as a precursor of Cr dispersed in the TiO2 network, together with the study of the influence of chromium content, on the photocatalytic activity of solids. The solids obtained by this technique were heat treated at 400ºC and characterized by Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, Diffuse Reflectance Spectroscopy, X-Ray Diffraction (XRD), N2 Sorptometry and Zeta Potential. Doping of titania with chromium stabilizes the crystalline phases of anatase and brookite. In addition, the introduction of chromium (VI) ions tends to reduce the average size of the particles, increasing the specific surface area and favoring the development of a mesoporous structure. It also decreases the forbidden band (Ex.) and increases the absorption of radiation in the visible light range. Thus, when irradiated with visible light, doped photocatalysts show interesting activity in photocatalytic degradation of azo dyes.

Revista Académica Digital. Recuperado, 2002