2002 Thiazine derivatives
Thiazine derivatives
R 0610 Preparation of Novel Derivatives of Pyridothiazine-1,1-dioxide and Their CNS an
Antioxidant Properties. — Starting from isothiazolopyridine-1,1-dioxide (I), the title
compounds (VI) possessing the 3-[4-(substituted-phenyl)piperazinyl]propyl or
3-(4-substituted-piperidinyl)propyl side chain at the thiazine nitrogen atom are pre-
pared and evaluated for their acute toxicity and for their influence on the spontaneous
locomotor activity, thiopental anaesthesia, carrageenan induced edema and analgesic
activity. — (MALINKA*, W.; KACZMARZ, M.; FILIPEK, B.; SAPA, J.; GLOD, B.;
Farmaco 57 (2002) 9, 737-746; Dep. Chem. Drugs, Wroclaw Univ. Med.,
PL-50-137 Wroclaw, Pol.; Eng.) — R. Langenstrassen
04- 160
2002
Thiazine derivatives
Thiazine derivatives
R 0610
Preparation of Novel Derivatives of Pyridothiazine-1,1-dioxide and Their CNS an
Properties. — Starting from isothiazolopyridine-1,1-dioxide (I), the title
04- 160 Antioxidant
compounds (VI) possessing the 3-[4-(substituted-phenyl)piperazinyl]propyl or
3-(4-substituted-piperidinyl)propyl side chain at the thiazine nitrogen atom are prepared and evaluated for their acute toxicity and for their influence on the spontaneous
locomotor activity, thiopental anaesthesia, carrageenan induced edema and analgesic
activity. — (MALINKA*, W.; KACZMARZ, M.; FILIPEK, B.; SAPA, J.; GLOD, B.;
Farmaco 57 (2002) 9, 737-746; Dep. Chem. Drugs, Wroclaw Univ. Med.,
PL-50-137 Wroclaw, Pol.; Eng.) — R. Langenstrassen
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