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Preparation of Novel Derivatives of Pyridothiazine-1,1-dioxide and Their CNS an Antioxidant Properties

ChemInform, 2003
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2002 Thiazine derivatives Thiazine derivatives R 0610 Preparation of Novel Derivatives of Pyridothiazine-1,1-dioxide and Their CNS an Antioxidant Properties. — Starting from isothiazolopyridine-1,1-dioxide (I), the title compounds (VI) possessing the 3-[4-(substituted-phenyl)piperazinyl]propyl or 3-(4-substituted-piperidinyl)propyl side chain at the thiazine nitrogen atom are pre- pared and evaluated for their acute toxicity and for their influence on the spontaneous locomotor activity, thiopental anaesthesia, carrageenan induced edema and analgesic activity. — (MALINKA*, W.; KACZMARZ, M.; FILIPEK, B.; SAPA, J.; GLOD, B.; Farmaco 57 (2002) 9, 737-746; Dep. Chem. Drugs, Wroclaw Univ. Med., PL-50-137 Wroclaw, Pol.; Eng.) — R. Langenstrassen 04- 160
2002 Thiazine derivatives Thiazine derivatives R 0610 Preparation of Novel Derivatives of Pyridothiazine-1,1-dioxide and Their CNS an Properties. — Starting from isothiazolopyridine-1,1-dioxide (I), the title 04- 160 Antioxidant compounds (VI) possessing the 3-[4-(substituted-phenyl)piperazinyl]propyl or 3-(4-substituted-piperidinyl)propyl side chain at the thiazine nitrogen atom are prepared and evaluated for their acute toxicity and for their influence on the spontaneous locomotor activity, thiopental anaesthesia, carrageenan induced edema and analgesic activity. — (MALINKA*, W.; KACZMARZ, M.; FILIPEK, B.; SAPA, J.; GLOD, B.; Farmaco 57 (2002) 9, 737-746; Dep. Chem. Drugs, Wroclaw Univ. Med., PL-50-137 Wroclaw, Pol.; Eng.) — R. Langenstrassen