,
,
25
JUVENILE HYPERTHYROIDISM ( J H ) : THERAPEUTIC
OPTIONS ACCORDING TO TIE PREDICTION OF THX EVOLUTION.
Iorcansky,S. ; Gruiieiro de Papendieck,L. ; Belgorosky,
A.; Rivarola, M.A.; Bergada, C. CEDIE-Division de
Endocrinologia Htal .Ninos "Gutierrez" , Bs. A s . ,
Argentina.
A t present no Laboratory t e s t is available to predict the
U m a f J H ( ~ ' ~ ) . A W l p t o 2 t o 1 4 ~ . w s ~ W i n
58 @cLmts
aged 2 4/12 t o 17 y. old (X r SD: 9.4 f 3.9). They a l l
received antithyroid drugs a s i n i t i a l treatment. Thirty s i x
patients followed f o r 3 t o 14 y., could be reevaluated with T ,
T3 and TSH and/or TRH a f t e r treatment i n a t l e a s t 2 ocassions?
a t short-term (ST: 1-2 y. post onset of treatment) and a t longterm (LT:mre than 3 y.; ji f 6.23 f 3.3). Twenty three patients
(64%) remained hyperthyroid (Hper) between ST and LT and 9(25%)
hypo o r euthyroid (Hpo/Eu) between ST and LT; only 4 (11%)
changed from Hper a t ST t o Hpo/Eu a t LT. Thus, 89% did not rcdfj'
t h e i r thyroid function between ST and LT. The period of the
evolution f m n Hper t o Hpo/Eu showed two d i s t i n c t populations,one
with a X i SD of 17.3 f 3.8 mnths and another with ji i SD of 9.4
i 2.5 y. I t is concluded that Amluationof thyroid flvlction a t
ST is usefhl to p d i c t t h e i r s t a t u s a t LT since 9% of patients
showed no variations. Since patients who changed thyroid ficticn
f m n Hper t o Hpo/Eu a t ST did it i n ji 17.3 months it is advisable
t o w a i t up t o t h i s time t o s e l e c t another therapeutic options.
I f Hper p e r s i s t s the possibility of I 131 administration should
be considered t o avoid the excessively long treatment required
by the unrelenting course of t h i s disease.
24
GRWM AND GRMJTH HORMONE SECRFP1,ON I N CHILDREN
WITH RENAL TRASNPWATICN. m n e , H . M . ; Jasper,H.;
Ferraris. J .R. ~ i v i s i b nde ~ndocrinologia. CEDIE,
Htal. de ~iiios"~.Gutierrez"y S e c c i k ~ e f r o l o g i a
~edi&trica,~tal.Italiano,
Buenos Aires.Argentina.
m
LO
LACK OF CORRELATION OF TCYTALESTRADIOL (To E2) AND
NON-SHBEBOUND E2 (non-SHBG-b E2)WITH GRMJTH \IEIOSPPI
DURINC PUBEFiTY I N NORMAL BOYS. Be1gorosky.A. ; ~ a r t i n e z
A.;Escobar.M.E.;Heinrich,J.J.;Rivarola,M.A. CEDIE.
Hospital de ~ i i i o s ,Buenos Aires, Argentina.
Recent evidence suggeststhat n o d growth during male puberty
depends on the ccmbined effect of testosterone(T) and growth
hormone while the role of estrogens, i f any,has not been
gtpLi3x%i. G x ~ l a t i c r 6Irmgudh m i t y (W) ad smm totalT('Ib T),
-T,
m ~ 2 ~ ~ - 1 m - ~ ~ x n ~ r ~ e i n 1 6 ~ t q r s ( m ; n i s ,
chtumlcgical @, 14.1 f 1.4, m f 9) tax? %J? 12.3 i 1.64 y?zm) in 'l'a?x's
LI-IV af gnital ckwlcprtnt. W w ealmtd in a 6-frmtb~erio3
tut
~wfalloKd~pfaratMlyear.NreaftksbjEctsMovermre
t k i r ~ k i @ t w l c c i t y a s ~ t y 3 c u ~ m 1 t i w ?T ~a dt Q
s.
~ f r a c t i n s ~ r r c a l a r l a t e d t ? , ' a n ~ c a l ~ l ~ m ~ ~
a f r r a s s ~ t i c n . M f S ) ' I b T a d W T H e r e ~ f 4 8 a d i 5w
f d
l
r-tiwly
wile m E2 ad
E2 al8.1 f 4.4 ad 9.07 t 2.88 &ml
rtqxctiwly. T b T T a d T T a h i @ l y sirpific;ntmlatimwim
~ ( p < o . o 1 i ) w ~ ~ c ; n t m l a t i c n ~ ~ 6 m ~ ~ m ~ ~
~FZadW.'hs?strrtigsggsttt-at-E2&smtpl;grarolein
W*~pdmrnoftqrs.
27
tUWWRY GLAND DEVEJJJFMEWT UNDER ?HE EFFECT OF A
PLAC~ALPROTEIN.Calaff,G.;C~wro,M.T.;Beas,F.
Universidad Metropolitans de Cs.de l a Educacion.
Centro de Investigaciones Matemo Infanti1,Hospital
Paula Jaraquemada, Facultad Medicina, Universidad de
Chile, Santiago, Chile.
~gnvthisa~prrhlanincNLdrrnwithreral~(?X).
protein f m n human placenta, the Uterotrophic Placental Protein
F t c r a l l c g r a f t ~ i i c n a d r d & ~ ~ ~ m nA ~
a S p r c t E b l e ~ a f ~ ~ ~ . W a l m a f t k ~ (UTTI-I)
t ~ was isolated i n our lab(E!eas & Flores.1969). It evoked crq,
sac stimtlation i n pigeons, inhibited mamnary growth produced by
\\Ez~: 1) to &t&
t
k effect m
belmtty (IN)af a redrejmWlestradiol (E) and progesterone (P) i n ovariectmized r a t s and
pErmrE (W) - a d z )
toenhtem(KH) Qrardcsw
increased DNA synthesis i n 5 day organ cultures of mouse rramery
~ t k g m ~ 2 4 ~ ~ i i c n . ~ s t ~ i i € d 7 7 1 ) ( t s
gland. The objective of t h i s work was t o analyze the effect of
(dwolcgical %J? 8.6 to 15.2 q ~ a r s ) ,with s?nm cresltinire f h n 0.5 to 0
.
w
UTPH on mamnary gland development i n i n t a c t virgin Balb/c mice
dl, r e Q i V i r g W a t a d r e s a f 0 . 2 3 + 0 . 0 e ~ @ ( x a ~ ) w i m a p r w i a s
injected during 8 days. There were four experimental groups: ( I )
W o f 2 . 5 8 a l . l 4 ~ . A f t ~ r c r e y z a r w i t h a ~ M ' (0,17fO,Qlrrg/kg/
iP
Control: 0.3 m l saline s o l . , ( I I ) E + P: 0.4 ug10.3 m l and 0.8 mg/
@),Ww3.42f1.94dyr. ( n = 7 ) a d 2 . 3 3 f 1 . 0 0 ~ . i n 4 1 ) ( t s ~
0.3 m l respectively, (111) E + P + UTPH: 203 ug/0.3 rnl and (IV)
-prrptEltaldrrirgtt-atyzar.
I n t k e 4 m m K H
UTPH. Results on who lemount mamnary gland indicated that there
-~mw2.58+0.99rs/ml,ro~~konammnlmtrol~:
was: a ) not s i s i f i c a n t difference among groups v s control i n the
2.78* 0.i6rg/ml (&)l\bt K H ~ 5 r>g / m l ~ e r e & t e c t e d i n 2 a f m
~ t s , v l ? i l e m m l m ~ s r o h e dt04Fe;lcs.
l
I
n
~
a
~
W number of m a m ~ l ygland ducts. b) a s i w i f i c a n t increase i n n n b ~
~ ~ d r o t i l p u e W i n ~ @ % m t s W i m I k a d ~ ~ of terminal end buds (TEB) i n group I1 v s I ( p <0.0035) and 111
(p(0.0035) o r I 1 vs IV (p<0.0005). c ) a s i f l i f i c a n t increase i n
c o l l d t e d a t e d , insnechildm,tominpbdKH-tim.
n u d e r of alveoli of group I I ( p < 0.0005) and I11 (p <0.0005) v s
control. We can conclude f m n these studies that UTPH inhibited
E + P action on TEB development while had no e f f e c t on ducts and
alveoli.
kwt
25
HMLW,CIWIH HXX
@MIX).
kjmi&,J.J.;
'
,A.S.;
~brere,~.;~iEFpS,~.;-,~.;~lo,~.;~~c.
(IDIE, Div. &
WqJ.B-tiM3 ".Ohierrez y
Suvicio&~ . & t i M 3 & l h d x I ,B.k.,
PULMONARY FINDINGS IN POS?MORTEM MAMINATIONS OF
PEDIATRIC ACQUIRED LWJhODEFICIENCI SINDROME (AIDS).
Adm,J.A. ;Birriel,J.A. ;Saldana,M.J. ;Vemon,D.
kpartment of Pediatrics, University of Miami School
of Medicine, Miami, F l . , U.S.A.
A retrospective study of autopsies of children with the diagnosis
of AIDS w a s done. Fmn March 1983 t o September 1986 a t o t a l of 24
autopsies were done i n children with AIDS a t the University of
Miami/Jackson Memrial Hospital. Twenty three cases were rwiared
a s t o the pulmonary pathology. In 21 cases the primary c w of
ckathwaspllrmary. Of-,
12 (5%) W
e@
?n
-Q
ai(G) tectet3al
alm or in antWdtim wim w
d InWSHcial Fmmnitis (LIP) ar
&
m(FB).aftka-8(S)MLIP.Fmafnp8als
WGpamnia(-E.mli).O-eca?afLIPwirn
~ ~ a n a s p . E u n r i2a
c a, ~ e s Q f L I P a d Q m E g w i m ( ~ )ad
,
c r e c a ? a f L P a d F B . W ~ c a l ~ a f ~ a l ~ & ~ a d
barotrarra -late
e
l
l clinically with tk Mtzr af cQ.5 m mtilatoly
28
-"
s+Fort,m i ~ o r o s t c & h u t i W . N c r e a f t t - e @ c L t s q i r e d a s a
s.c. ad i.m mix ~ t i - e l y tut
, titers err I
m ad did rot inpir
pdm..elccity. m m h i 3 - 6 w i t h ~1 A C H ) ~ e a r l y ~ h i ~
mtiin$~titers. Gnwth ..et?lccityfell in cre hh rot in tk o w .
AlUn&ro~tdif&mcsintk~gmvthiicneffectHere
~ a f L P a l c r e . O ~ d a t a i r r b l c a b s : # l l r l l t i p l e ~ ~ t o
~ m ~ t ~ e i n g d ~ ~ q L m t a y f a F l L n e i n ~ c h i l d 1 m . # 2
LIP~ctrsrotqpzrtoteacaeofgdstag3~fai~,
kwser, LIPalmwitheith?rviralartscterialFBtkgrsamant£arSaf
~ t e d t e m t o r n ~ t g u p ~ C e . e ~ w s r r ~ r e
tkphtmqFaanlcgcdiap-csis. #3GEwterlalFatrogrspl;grmirrFort;nt
m t l y yse7 after S.C. m G m i acfrrir ' ' ' . All W m t s ircreaaxl
slguflmtly tk grc4m w m t y ad firal ki@t Frcgffis, withut
lnleindm-faiWinNI.6.
#4W~eaf%skmicM&
f o r t k ~ t a f L I P i n a d ~ , ~ t e o n ~ i n l i g . t a f a - .
.
lccal or
site effects.
w
p
h
t
m
q
.
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