Asthma is a complex disease with sex-specific differences in prevalence. Candidate gene studies have suggested that genotype-by-sex interaction effects on asthma risk exist, but this has not yet been explored at a genome-wide level. We aimed to identify sex-specific asthma risk alleles by performing a genome-wide scan for genotype-by-sex interactions in the ethnically diverse participants in the EVE Asthma Genetics Consortium. We performed male- and female-specific genome-wide association studies in 2653 male asthma cases, 2566 female asthma cases and 3830 non-asthma controls from European American, African American, African Caribbean and Latino populations. Association tests were conducted in each study sample, and the results were combined in ancestry-specific and cross-ancestry meta-analyses. Six sex-specific asthma risk loci had P-values < 1 × 10(-6), of which two were male specific and four were female specific; all were ancestry specific. The most significant sex-specific a...

A Bölcsészet-, Nyelv-és Történettudományi Szakosztály konferenciájára november 22-én került sor: az EME kutatóintézetének munkatársai mutatkoztak be. A kutatóintézetet dr. Kovács András igazgató mutatta be. Ezt követően Biró Annamária, Bogdándi Zsolt, Fejér Tamás, Hegyi Géza, Ilyés Szilárd-Zoltán, Nagy Mihály Zoltán, Szász Anikó, W. Kovács András tartottak előadást. Az előadásokat élénk érdeklődés és vita követte. A rendezvényt 30–35 fős hallgatóság kísérte figyelemmel. A programot dr. Keszeg Vilmos és dr. Egyed ...

Often neglected by historians today, the seventeenth-century philosophers known as the Cambridge Platonists were recognised in their time as some of the most influential and controversial philosophers in England. Whereas most studies of the Cambridge Platonists have discussed their later careers, this book focuses on their early, formative years at Cambridge during the English Civil Wars. Samuel M. Kaldas explores how the Cambridge Platonists addressed issues central to philosophy of religion as we know it today through their engagement with early seventeenth-century religious controversies about predestination, the character and nature of God, and the role of reason in religion. His study serves as an accessible introduction to both the Cambridge Platonists, and to English religious controversies that contributed to the birth of the modern philosophy of religion. At the same time, Kaldas provides context for and fresh insights into the Cambridge Platonists' intellectual development and the coherence of their thought.

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Medically prescribed diacetylmorphine, the active ingredient of heroin, has been shown to be effective for the treatment of severe opioid addiction. However, there are no data regarding its effectiveness among Aboriginal heroin injectors. The present analyses were performed using data from the NAOMI study (North American Opiate Maintenance Initiative), an open-label randomized controlled trial that compared the effectiveness of injectable diacetylmorphine (45.8%) and hydromorphone (10%) vs. oral methadone (44.2%) among long-term treatment-refractory opioid-dependent individuals. Rates of retention and response to treatment were analyzed among participants from the Vancouver site (n = 192). Baseline profiles were similar among Aboriginal (n = 60) and non-Aboriginal (n = 132) participants except for higher HIV positive rates among Aboriginal people (23.3% vs. 8.3%). Among Aboriginal participants in the injection and methadone groups, retention rates at 12 months were 84.4% vs. 57.1% a...