DNA cryptography is a modern promising path in cryptography research that surfaced with the improvement in Deoxyribonucleic Acid (DNA) computing field. Traditional cryptographic systems have an extended legacy and are designed on a solid mathematical and theoretical basis. Thus, an important notion must be developed that the DNA cryptography is never to negate the tradition, but to make a bridge between existing and new technology. The strength of DNA computing will fortify the existing security systems by checking up a new probability of the hybrid cryptographic system. This paper aims to present a proposed DNA sequence enhanced Advanced Encryption standard (AES) design. The proposed algorithm has been implemented with all its features (data, algorithms operations and used functions) on DNA sequence rather than bits in mix column step. The proposed technique demonstrates the possibility of building such an intricate system of DNA sequence in a method for making it an appropriate contender for usage in the biological environment or on DNA computers. The presented algorithm keeps a security quality and strength of the standard algorithm. The assessment of the presented method is carried out using MATLAB 2016b. The experimental results show a significant improvement in terms of breaking time for different text file sizes.
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