Lecture Notes in Computer Science Edited by G. Goos, J. Hartmanis, and J. van Leeuwen 2526 3 Berlin Heidelberg New York Barcelona Hong Kong London Milan Paris Tokyo Alfredo Colosimo Alessandro Giuliani Paolo Sirabella (Eds.) Medical Data Analysis Third International Symposium, ISMDA 2002 Rome, Italy, October 10-11, 2002 Proceedings 13 Series Editors Gerhard Goos, Karlsruhe University, Germany Juris Hartmanis, Cornell University, NY, USA Jan van Leeuwen, Utrecht University, The Netherlands Volume Editors Alfredo Colosimo Paolo Sirabella Dept. of Human Physiology and Pharmacology University of Rome La Sapienza P. le A. Moro, 5, 00185 Rome, Italy E-mail: a.colosimo@caspur.it paolo.sirabella@uniroma1.it Alessandro Giuliani TCE Laboratory, Istituto Superiore di Sanità V. le Regina Elena, 299, 00161 Rome, Italy E-mail: alessandro.giuliani@iss.it Cataloging-in-Publication Data applied for Bibliograhpic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the Internet at http://dnb.ddb.de CR Subject Classification (1998): I.2, H.2.8, H.3, G.3, I.5.1, I.4, J.3, F.1 ISSN 0302-9743 ISBN 3-540-00044-5 Springer-Verlag Berlin Heidelberg New York This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer-Verlag Berlin Heidelberg New York a member of BertelsmannSpringer Science+Business Media GmbH http://www.springer.de © Springer-Verlag Berlin Heidelberg 2002 Printed in Germany Typesetting: Camera-ready by author, data conversion by Boller Mediendesign Printed on acid-free paper SPIN: 10873138 06/3142 543210 Preface The International Symposium on Medical Data Analysis is an important periodical opportunity to exchange ideas and first-hand experiences with groups interested in the medical applications of innovative hardware and software tools. The massive information available through continuous improvements in the various modeling approaches to Medical Data Analysis is reflected in the results, dealing with quite different topics, presented during the Third Edition of the Symposium (ISMDA 2002). They have been grouped into the following four categories: (1) Data Mining and Decision Support Systems; (2) Medical Informatics and Modeling; (3) Time-Series Analysis; and (4) Medical Imaging. In setting up the symposium program we tried to avoid, even with the shortage of time, parallel sessions. Thus, all participants had the chance to catch all the oral presentations, and we hope that this third proceedings volume will extend this chance also to non-participants. As for the previous volumes, it contains extensive up-to-date chapters on Medical Data Analysis, packed with ideas, suggestions, and solutions to many problems typical of this field. An appealing feature of ISMDA is the informal character coupled to a careful selection and reviewing procedure for the submitted contributions, which guaranteed a high-quality standard within a relaxing and friendly environment. In this connection, it is not only fair but also a great pleasure for us to thank the many people involved in the set-up of ISMDA 2002, from the authors to the organizing committee to the international panel of reviewers, all of them provided an invaluable contribution to the success of the symposium. September 2002 Alfredo Colosimo Alessandro Giuliani Paolo Sirabella Organization The ISMDA 2002 symposium was organized by the CISB, the Interdepartmental Research Centre for Models and Information Analysis in Biomedical Systems, University of Rome, La Sapienza, Italy. Scientific Committee A. Babic R. Brause A. Colosimo S. Cerutti N. Ezquerra A. Giuliani J. Hasenkam H.G. Holzütter E. Keravnou P. Larranaga N. Lavrac R. Lefering A. Macerata V. Maojo E. Neugebauer C. Ohmann L. Ohno-Machado A. Pazos L. Pecen W. Sauerbrei B. Sierra B. Silverman J. Sima P. Sirabella H. Sitter J.P. Zbilut B. Zupan Linköping University, Sweden J.W. Goethe University, Germany University of Roma, La Sapienza, Italy Polytechnic School, Milano, Italy Georgia Tech., USA Nat. Inst. of Health, Italy Aarhus University, Denmark Humboldt University of Berlin, Germany University of Cyprus, Cyprus University of the Basque Country, Spain J. Stefan Institute, Slovenia University of Köln, Germany Institute of Clinical Physiology, Italy Polytechnical University of Madrid, Spain University of Köln, Germany University of Heine, Germany Harvard Univ., USA University of A. Coruña, Spain Acad. of Sciences of the Czech Republic, Czech Republic University of Freiburg, Germany University of the Basque Country, Spain University of Pennsylvania, USA Acad. of Sciences of the Czech Republic, Czech Republic University of Rome, La Sapienza, Italy University of Marburg, Germany Rush University, Chicago, USA University of Ljubljana, Slovenia Table of Contents Data Mining and Decision Support Systems Knowledge Discovery Using Medical Data Mining . . . . . . . . . . . . . . . . . . . . . . F. Alonso, Á. López-Illescas, L. Martı́nez, C. Montes, J.P. Valente 1 Analysis of Stationary Periods of Heart Rate via Symbolic Dynamics . . . . . 13 C. Cammarota, G. Guarini, M. Ambrosini Microcalcification Detection Using a Kernel Bayes Classifier . . . . . . . . . . . . . 20 B. Caputo, E. La Torre, G.E. Gigante The Use of Classification Trees for Analysis of Kidney Images in Computer Assisted Microscopy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 E. Kaczmarek, E. Nieruchalska, M. Michalak, A. Wozniak, W. Salwa-Zurawska A Neuro-fuzzy Based Alarm System for Septic Shock Patients with a Comparison to Medical Scores . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 J. Paetz, B. Arlt Determination of Functional Relationships for Continuous Variables by Using a Multivariable Fractional Polynomial Approach . . . . . . . . . . . . . . . . . 53 W. Sauerbrei, P. Royston Medical Informatics and Modeling Nonlinear Oscillation Models for Spike Separation . . . . . . . . . . . . . . . . . . . . . . 61 T.I. Aksenova, O.K. Chibirova, A.-L. Benabid, A.E.P. Villa Modeling Glucose-Insulin Behavior in Ill Patients (DM Type 2) . . . . . . . . . . 71 G. Baratta, F. Barcellona, G. Lucidi, A.M. Bersani ECG Acquisition and Management System for Knowledge Discovery in Database: Data Modeling, Design, and Implementation . . . . . . . . . . . . . . . . . 79 Y. Cho, H. Kim, M.-j. Jeon, D. Kang, H. Choi, J.-m. Lee, I.-y. Kim, S.I. Kim The Conceptual Basis of WITH, a Collaborative Writer System of Clinical Trials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86 P. Fazi, D. Luzi, F.L. Ricci, M. Vignetti Problems of the Model Choice in Classes of Mendelian Inheritance Models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 98 B. Jäger, K.-E. Biebler VIII Table of Contents Computational Modeling of the Cardiovascular System After Fontan Procedure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105 E.B. Shim, C.H. Youn, T. Heldt, R.D. Kamm, R.G. Mark Time-Series Analysis Short- and Long-Term Statistical Properties of Heartbeat Time-Series in Healthy and Pathological Subjects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115 P. Allegrini, R. Balocchi, S. Chillemi, P. Grigolini, L. Palatella, G. Raffaelli An Index of Organization of the Right Atrium During Atrial Fibrillation: Effects of Internal Cardioversion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127 V. Barbaro, P. Bartolini, G. Calcagnini, F. Censi, A. Michelucci, S. Poli Morphological Analysis of ECG Holter Recordings by Support Vector Machines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 134 S. Jankowski, J. Tijink, G. Vumbaca, M. Balsi, G. Karpinski Monitoring of Sleep Apnea in Children Using Pulse Transit Time . . . . . . . . 144 J. Pagani, M.P. Villa, G. Calcagnini, E. Lombardozzi, F. Censi, S. Poli, P. Bartolini, V. Barbaro, R. Ronchetti Linear and Nonlinear Evaluation of Ventricular Arrhythmias . . . . . . . . . . . . 151 J.P. Zbilut, P.A. Santucci, S.-Y. Yang, J.L. Podolski Invariant and Subject-Dependent Features of Otoacoustic Emissions . . . . . . 158 G. Zimatore, A. Giuliani, S. Hatzopoulos, A. Martini, A. Colosimo Medical Imaging Short Term Evaluation of Brain Activities in fMRI Data by Spatiotemporal Independent Component Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167 M. Balsi, V. Cimagalli, G. Cruccu, G.D. Iannetti, A. Londei, P.L. Romanelli Implementation of an IT System for the Support of a Hospital Infection Surveillance System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177 M. Behnke, T. Eckmanns, H. Rüden An Artificial Neural Network for 3D Localization of Brainstem Functional Lesions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 186 M. Capozza, G.D. Iannetti, J.J. Marx, G. Cruccu, N. Accornero Dependent Rendering: Visualizing Multiple Properties of an Object . . . . . . 198 S. Löbbert, S. Märkle Table of Contents IX Automatic Detection of Microaneurysms in Color Fundus Images of the Human Retina by Means of the Bounding Box Closing . . . . . . . . . . . . . . . . . . 210 T. Walter, J.-C. Klein Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221