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2007, Journal of Hepatology
2006 •
Liver International
Endogenous opioids modulate hepatocyte apoptosis in a rat model of chronic cholestasis: the role of oxidative stress2007 •
Morphine exhibits important pharmacological effects for which it has been used in medical practice for quite a long time. However, it has a high addictive potential and can be abused. Long-term use of this drug can be connected with some pathological consequences including neurotoxicity and neuronal dysfunction, hepatotoxicity, kidney dysfunction, oxidative stress and apoptosis. Therefore, most studies examining the impact of morphine have been aimed at determining the effects induced by chronic morphine exposure in the brain, liver, cardiovascular system and macrophages. It appears that different tissues may respond to morphine diversely and are distinctly susceptible to oxidative stress and subsequent oxidative damage of biomolecules. Importantly, production of reactive oxygen/nitrogen species induced by morphine, which have been observed under different experimental conditions, can contribute to some pathological processes, degen-erative diseases and organ dysfunctions occurring in morphine abusers or morphine-treated patients. This review attempts to provide insights into the possible relationship between morphine actions and oxidative stress.
Neurochemical Research
Assessment of Oxidative Damage Induced by Acute Doses of Morphine Sulfate in Postnatal and Adult Rat Brain2006 •
The aim of the present study is to evaluate the oxidative damage in rats of different ages. Weaned rats of 25 g and adults of 300 g were used in groups of 6, a single i.p. dose of morphine sulfate of 3, 6 or 12 mg/kg was administered. All animals were sacrificed to measure GSH and 5-HT levels in brain by liquid chromatography, as well as Na+, K+-ATPase and total ATPase enzymatic activity. 5-HT levels decreased significantly (p+, K+-ATPase activity increased significantly (p+, K+-ATPase and total ATPase partially diminished. GSH levels diminished significantly (p
Addiction with opium and its derivatives represent one of the major problems worldwide. The main objective of this study is to estimate the immunomodulatory chemokine , liver oxidative enzyme markers and apoptosis in opium addicted rats via intraperitoneal injection. Thirty male rats were randomly distributed into three groups. Group 1 regarded as control, while in group2 and 3, the animals were daily injected intraperitoneally with (25 and 50 mg opium/kg b.w.) for seven successive days. The level of Monocyte Chemoattractant Protein-1 (MCP-1) chemokine was estimated within sera samples using ELISA special kit. Enzymatic levels of alkaline phosphatase (ALP), Xanthine Oxidase (XO), Glucose-6-phosphate dehydrogenase (G6PDH) and lactate dehydrogenase (LDH) in serum were assayed, and concentration of Malondialdehyde (MDA) estimated, besides determining the percent count of apoptotic hepatocytes. Significant induction was observed in MCP-1 level. The activity of ALP and XO were significantly and dose dependently changed, whereas the MDA significantly elevated in both doses, but there were no difference between the two doses. A significant reduction was occurred in G6PD in both low and high doses. The frequency of apoptotic hepatocytes significantly increase in concentration dependent manner. This study suggests that intraperitoneal injection of opium causes immunomodulation through induction of MCP-1 and also causes alteration in liver oxidant and antioxidant balance. Hepatocyte apoptosis occurred in concentration dependent manner.
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Effect of chronic morphine treatment on time-course of free radical processes2007 •
Neurochemical Research
Spinal Morphine Administration Reduces the Fatty Acid Contents in Spinal Cord and Brain by Increasing Oxidative Stress2006 •
Neuropsychiatrie De L'enfance Et De L'adolescence
Transmission du traumatisme. La question de l’attachement désorganisé : de la théorie à la pratique2012 •
2024 •
VIAJE A LOS MUNDOS SUPERIORES Y EL CAMINO HACIA LA CONSCIENCIA CRÍSTICA.
2019 •
Roman Identity: Between Ideal and Performance, edited by Lautaro Roig Lanzillotta, José Luís Brandão, Cláudia Teixeira, and Ália Rodrigues. Brepols.
What's in a Natio: Negotiating Ethnic Identity in the Roman Empire2022 •
Bangabandhu Sheikh Mujib Medical University Journal
Survival and toxicity outcomes of induction chemotherapy followed by concurrent chemoradiotherapy compared with concurrent chemoradiotherapy alone in inoperable stage III and IVA/B head and neck cancer2022 •
War in History
A summer on Hounslow Heath: Combined army operations in late-seventeenth-century England2021 •
Biomedical and Pharmacology Journal
Anthropometric Analysis of Femur in South Indian Population2020 •
Italian journal of food sciences
Nutritional assessment concerning anthropometric, demographic, and food frequency questionnaires of hemodialysis patients in Sargodha, Pakistan2024 •
Neurobiology of Disease
Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease2018 •
Journal of Food and Dairy Sciences
Effect of Different Bacterial Strains on Like-Labneh Products from Buffaleo's Milk and Hull-Less Barley2008 •
Ecology and the Environment
Hydrological regime alteration and ecological flow evaluation in mountain rivers2015 •
2009 •
2008 •
Revista Política y Estrategia
The Military and Internal Security Operations in Latin AmericaThe Lancet Diabetes & Endocrinology
Diabetes in humanitarian crises: the Boston Declaration2019 •
2017 •