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PLoS ONE
Is IP-10 an Accurate Marker for Detecting M. tuberculosis-Specific Response in HIV-Infected Persons?2010 •
European Respiratory Journal
Potential of interferon- -inducible protein 10 in improving tuberculosis diagnosis in HIV-infected patients2010 •
2016 •
In the absence of a gold standard for the diagnosis of latent tuberculosis (TB) infection (LTBI), the current tests available for the diagnosis of LTBI are limited by their inability to differentiate between LTBI and active TB disease. We investigated IP-10 as a potential biomarker for LTBI among household contacts exposed to sputum positive active TB cases. Active TB cases and contacts were recruited into a cohort with six months' follow-up. Contacts were tested for LTBI using QuantiFERON®-TB Gold In-Tube (QFN) assay and the tuberculin skin test (TST). Baseline supernatants from the QFN assay of 237 contacts and 102 active TB cases were analysed for Mycobacterium tuberculosis (MTB) specific and mitogen specific IP-10 responses. Contacts with LTBI (QFN+TST+) had the highest MTB specific IP-10 responses at baseline, compared to uninfected contacts (QFN-TST-) p<0.0001; and active cases, p = 0.01. Using a cut-off of 8,239 pg/ml, MTB specific IP-10 was able to diagnose LTBI with ...
2012 •
BackgroundThe performance of the tuberculosis specific Interferon Gamma Release Assays (IGRAs) has not been sufficiently documented in tuberculosis- and HIV-endemic settings. This study evaluated the sensitivity of the QuantiFERON TB-Gold In-Tube (QFT-IT) in patients with culture confirmed pulmonary tuberculosis (PTB) in a TB- and HIV-endemic population and the effect of HIV-infection and CD4 cell count on test performance.Methodology/Principal Findings161 patients with sputum culture confirmed PTB were subjected to HIV- and QFT-IT testing and measurement of CD4 cell count. The QFT-IT was positive in 74% (119/161; 95% CI: 67–81%). Sensitivity was higher in HIV-negative (75/93) than in HIV-positive (44/68) patients (81% vs. 65%, p=0.02) and increased with CD4 cell count in HIV-positive patients (test for trend p=0.03). 23 patients (14%) had an indeterminate result and this proportion decreased with increasing CD4 cell count in HIV-positive patients (test for trend p=0.03). Low CD4 cell count (<300 cells/µl) did not account for all QFT-IT indeterminate nor all negative results. Sensitivity when excluding indeterminate results was 86% (95% CI: 81–92%) and did not differ between HIV-negative and HIV–positive patients (88 vs. 83%, p=0.39).Conclusions/SignificanceSensitivity of the QFT-IT for diagnosing active PTB infection was reasonable when excluding indeterminate results and in HIV-negative patients. However, since the test missed more than 10% of patients, its potential as a rule-out test for active TB disease is limited. Furthermore, test performance is impaired by low CD4 cell count in HIV-positive patients and possibly by other factors as well in both HIV-positive and HIV-negative patients. This might limit the potential of the test in populations where HIV-infection is prevalent.
2010 •
BioMed Research International
Blood or Urine IP-10 Cannot Discriminate between Active Tuberculosis and Respiratory Diseases Different from Tuberculosis in Children2015 •
2017 •
Rima u poetici divanske književnosti ima svoje mjesto, osobito u strukturalnoj poetici, ali nju ne treba promatrati izolirano, vec kao sastavni dio cjeline poetskoga djela. U ovom radu nastojali smo predstaviti fenomen bogatstva i raznolikosti rime u divanskoj književnosti Bosnjaka na primjeru poezije Sabita Alaudina Užicanina, tragajuci za sto sirim jedinstvenim modelom analize rime sa razlicitih jezickostilistickih aspekata. U taj model analize uvrstili smo i grafostilisticki pristup analizi i klasifikaciji rime koji je dominantan u klasicnoj osmanskoj stilistici. Razlog za takav pristup je jednostavan: rima u divanskoj poeziji ne ispoljava se samo na grafostilistickoj razini analize teksta bilo koje poeme, nego predstavlja fenomen koji se odražava na ukupnu strukturu svake poeme pojedinacno na gotovo svakoj jezicnostilistickoj razini analize. U ovom radu skrenuli smo pažnju na preko stotinu vrsta rime samo u poeziji Sabita Užicanina. Model za klasifikaciju rime u divanskoj poezij...
The Catholic Church, Jews, the Shoah and the State of Israel: Interpretations and Responses
The Catholic Church, Jews, the Shoah and the State of Israel2023 •
Judaism and Christianity are religions whose theological epistemology is based on revelation. The primary source of revelation is Holy Scripture. However, history has also been recog nised as a source of revelation, particularly the history of Israel and the Jewish people. Because they understood history as a source of revelation, many religious Jews altered their understanding of Jewish statehood in Eretz Israel during the twentieth century, from distinctly averse to increasingly supportive. On the same principles, the Catholic Church made arguably the most profound change in its theology in the twentieth century, concerning its understanding of Jews and Judaism. This was prompted by an other major historical event, the Shoah. While in Judaism the historical phenom enon of the State of Israel profoundly influenced theology, another historical phenomenon, the Shoah, was theologically approached with far more unease and ambiguity. In the Catholic Church, in contrast, the historical phenomenon of the Shoah prompted a serious reconsideration of certain tenets of theology, includ ing soteriology, while the historical phenomenon of the State of Israel did not. This article addresses this apparent contradiction comparatively.
Cahiers du Monde Russe
«Союз родства и узы крови» : генеалогия и структура правящей элиты России 1725-1762 гг. [“Union of kinship and blood ties”: Genealogy and structure of Russia’s ruling elite (1725-1762)]2024 •
Изучение родственных связей правящего слоя России 1725-1762 гг. позволило выявить структуру элиты: ее внутренний круг (40% элиты; в т. ч. ядро, этим термином обозначены наиболее сплоченные сообщества – 10%), внешний круг (16%) и периферию (44%). Анализ показал, что между местом человека в этой сети родства, его карьерой и благосостоянием существовала очень сильная взаимосвязь. Кроме того, как оказалось, Табель о рангах существенно ограничила вертикальную мобильность – интенсивность пополнения состава элиты новыми людьми в 1725-1762 гг. была вдвое ниже, чем в 1613-1689 гг. Табель поддерживала «непотизм» старых фамилий и способствовала его распространению среди новых. Конечно, Табель о рангах была продуктом рационального стиля мышления, однако выявленная тесная взаимосвязь между родственными отношениями и службой позволяет поставить под сомнение укоренившуюся точку зрения, что созданная Петром I система чинопроизводства кардинально отличалась от старой московской.
Philippine Studies: Historical and Ethnographic Viewpoints
Rev. John N. Schumacher SJ, 1927–20142014 •
American Ethnologist
Recovering Debts: Microfinance Loan Officers and the Work of "Proxy-Creditors" in India2013 •
100. Yılında Türkiye Cumhuriyeti
Halkçılık Programı'ndan Teşkilât-ı Esâsiye Kanunu'na Yapısal Dönüşüm Üzerine Düşünceler2023 •
ECS Journal of Solid State Science and Technology
Investigating the Emission Characteristics of Single Crystal YAG When Activated by High Power Laser Beams2016 •
2003 •
… Problems, Priorities and …
Improved Land Management in the Lake Victoria Basin: Annual Technical Report, July 2000 to June 20012001 •
International Journal of Pharmacy
Toxicological Studies of an Ayurvedic Medicine “Karpur Ras” Used in DiarrhoeaRegion i mir
Understanding the Role of Internal and ESG Factors in Economic Growth: Panel Regression Findings2024 •
Diseases of Aquatic Organisms
Seroepidemiology of parapoxvirus infections in captive and free-ranging California sea lions Zalophus californianus2006 •
Journal of Geophysical Research: Oceans
Improved constraints on transit time distributions from argon 39: A maximum entropy approach2010 •
Jurnal Kesehatan Indonesia : The Indonesian Journal of Health
Implementasi Quality Control (QC) Penggunaaan Alat Point Of Care Testing (POCT) sebagai Upaya Jaminan Mutu Hasil Pemeriksaan di Puskesmas Cempaka Kota Banjarmasin2023 •