Location via proxy:   [ UP ]  
[Report a bug]   [Manage cookies]                
paper cover icon
A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity

2012
Abstract
Abstract Recombinant immunotoxins (RITs) are anti-cancer agents that combine the Fv of an antibody against cancer cells with a protein toxin from bacteria or plants. Since RITs contain a non-human protein, immunogenicity can be an obstacle in their development. In this study, we have explored the hypothesis that increasing stability can reduce the immunogenicity of a RIT using HA22-LR, which is composed of an anti-CD22 Fv fused to domain III of Pseudomonas exotoxin A.

Changhoon Kim hasn't uploaded this paper.

Let Changhoon know you want this paper to be uploaded.

Ask for this paper to be uploaded.