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We study dynamical properties of confined, self-propelled Brownian particles in an inhomogeneous activity profile. Using Brownian dynamics simulations, we calculate the probability to reach a fixed target and the mean first passage time to the target of an active particle. We show that both these quantities are strongly influenced by the inhomogeneous activity. When the activity is distributed such that high-activity zone is located between the target and the starting location, the target finding probability is increased and the passage time is decreased in comparison to a uniformly active system. Moreover, for a continuously distributed profile, the activity gradient results in a drift of active particle up the gradient bearing resemblance to chemotaxis. Integrating out the orientational degrees of freedom, we derive an approximate Fokker-Planck equation and show that the theoretical predictions are in very good agreement with the Brownian dynamics simulations.
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Advances in modern medicine and technology represent the factual premise to deal with the question of legitimateness and justification of non-strictly therapeutic interventions on a 'quite new' class of individuals termed in the 1990s 'un-patients'. Main aim of this paper is to identify the major ethical and legal aspects concerning this topic today, in order to define the borders of the map traced with regard to the ethical and legal debate some decades ago. A close examination of the ethical dilemmas of non-strictly therapeutic interventions will highlight characteristic perspectives and specificity of treatments administered to unpatients. To some of these peculiarities legal regulation has already provided answers, whereas with regard to other aspects a balance among different principles at stake is needed along with mechanisms set to safeguard their implementation. SUMMARY: 1. Introduction-2. Developments in modern medicine as premise for the debate on non-thera...
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