Genomics in Neurospora crassa: From One-Gene-One-Enzyme to 10,000 Genes

Neurospora crassa was the central organism in the development of biochemical genetics, providing a model system that established the relationship between genes and enzymes; it remains the best-studied filamentous fungus. This review focuses on the impact that the recent publication of a high-quality draft sequence of the N. crassa genome will have upon efforts to understand the biology of the