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2001, ChemInform
Molecules
Regioselective Functionalization of Quinolines through C-H Activation: A Comprehensive ReviewQuinoline is a versatile heterocycle that is part of numerous natural products and countless drugs. During the last decades, this scaffold also became widely used as ligand in organometallic catalysis. Therefore, access to functionalized quinolines is of great importance and continuous efforts have been made to develop efficient and regioselective synthetic methods. In this regard, C-H functionalization through transition metal catalysis, which is nowadays the Graal of organic green chemistry, represents the most attractive strategy. We aim herein at providing a comprehensive review of methods that allow site-selective metal-catalyzed C-H functionalization of quinolines, or their quinoline N-oxides counterparts, with a specific focus on their scope and limitations, as well as mechanistic aspects if that accounts for the selectivity.
2002 •
The salient features of clays, their modified forms (pillared and 'doped' with reagents) and their application in organic synthesis are described. A wide variety of chemical reactions such as addition, isomerization, rearrangement, electrophilic substitution etc. are presented ...
In this perspective, we review those stereoselective photocatalytic reactions that use synergy between photoredox catalysts and transition metal catalysts. In particular, we highlight the orchestrated interaction between two and more...
Organic Process Research & Development
Some Items of Interest to Process Chemists and Engineers2010 •
Chem. Soc. Rev.
A comprehensive overview of directing groups applied in metal-catalysed C-H functionalisation chemistry2018 •
The present review is devoted to summarizing the recent advances (2015-2017) in the field of metal-catalysed group-directed C-H functionalisation. In order to clearly showcase the molecular diversity that can now be accessed by means of directed C-H functionalisation, the whole is organized following the directing groups installed on a substrate. Its aim is to be a comprehensive reference work, where a specific directing group can be easily found, together with the transformations which have been carried out with it. Hence, the primary format of this review is schemes accompanied with a concise explanatory text, in which the directing groups are ordered in sections according to their chemical structure. The schemes feature typical substrates used, the products obtained as well as the required reaction conditions. Importantly, each example is commented on with respect to the most important positive features and drawbacks, on aspects such as selectivity, substrate scope, reaction conditions, directing group removal, and greenness. The targeted readership are both experts in the field of C-H functionalisation chemistry (to provide a comprehensive overview of the progress made in the last years) and, even more so, all organic chemists who want to introduce the C-H functionalisation way of thinking for a design of straightforward, efficient and step-economic synthetic routes towards molecules of interest to them. Accordingly, this review should be of particular interest also for scientists from industrial R&D sector. Hence, the overall goal of this review is to promote the application of C-H functionalisation reactions outside the research groups dedicated to method development and establishing it as a valuable reaction archetype in contemporary R&D, comparable to the role cross-coupling reactions play to date.
Beilstein Journal of Organic Chemistry
Matsuda–Heck reaction with arenediazonium tosylates in water2015 •
Current Organic Chemistry
Isolation, Biological Activities and Synthesis of Indoloquinoline Alkaloids: Cryptolepine, Isocryptolepine and Neocryptolepine2011 •
Abstract: Different cross-coupling reactions for the formation of biologically important motifs and intermediates in organic synthesis using various suitable copper catalysts are reviewed. These include C-C, C-N, C-O, C-S heteroatom bond forming, cyclization and other miscellaneous reactions catalyzed by elemental copper, copper salts, CuI, Cu (OTf)2, CuBr, Cu2O etc. The use of copper reagents instead of palladium catalysts and ligands seems to be advantageous from the commercial point of view. The methods described herein afford the products in excellent yield without using expensive and moisture/air sensitive palladium catalysts, ligands and reagents.
2013 •
Accounts of Chemical Research
Microwave-Accelerated Homogeneous Catalysis in Organic Chemistry2002 •
Clean Technologies and Environmental Policy
Solvent-free organic syntheses on mineral supports using microwave irradiation1999 •
Molecules (Basel, Switzerland)
Facile and Green Synthesis of Saturated Cyclic Amines2017 •
2014 •
Organic Process Research & Development
Latest Highlights in Liquid-Phase Reactions for Organic Synthesis in Microreactors2013 •
Coordination Chemistry Reviews
Catalytic C–C coupling through C–H arylation of arenes or heteroarenes2010 •
2003 •
Topics in Organometallic Chemistry
Recent Developments in Recyclable Copper Catalyst Systems for C–N Bond Forming Cross-Coupling Reactions Using Aryl Halides and Arylboronic Acids2013 •
Current Organic Chemistry
Copper Promoted CN and CO Type Cross-Coupling Reactions2010 •
Microwaves in Organic Synthesis
Wave–Material Interactions, Microwave Technology and Equipment2002 •
Photochemistry and Photophysics - Recent Advances [Working Title]
Visible-Light Photocatalysis of Aldehyde and Carbonyl Functionalities, an Innovative Domain2012 •
Arabian Journal of Chemistry
Recent Advances in 4-Hydroxycoumarin Chemistry. Part 1: Synthesis and Reactions2015 •
2010 •
ChemInform
ChemInform Abstract: Molecular Iodine, an Efficient and Versatile Reagent for Organic Synthesis2012 •
Bioorganic & Medicinal Chemistry Letters
Chloroquine–astemizole hybrids with potent in vitro and in vivo antiplasmodial activity2009 •
2006 •
Current Organic Synthesis
Recent Progress in Transition-Metal-Catalyzed C-N Cross-Couplings: Emerging Approaches Towards Sustainability2011 •
ACS combinatorial science
Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocol2011 •
2010 •
2016 •
Drug Discovery Today
Microwave-assisted high-speed chemistry: a new technique in drug discovery2001 •