study of pacemakers

European Heart Journal, 2007

Pacing and Clinical Electrophysiology, 2010

Journal of Electrocardiology, 2019

Journal of Cardiovascular Electrophysiology, 2002

2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2007

Frontiers in Physiology, 2021

BackgroundThe sinoatrial/sinus node (SAN) is the primary pacemaker of the heart. In humans, SAN is surrounded by the paranodal area (PNA). Although the PNA function remains debated, it is thought to act as a subsidiary atrial pacemaker (SAP) tissue and become the dominant pacemaker in the setting of sinus node disease (SND). Large animal models of SND allow characterization of SAP, which might be a target for novel treatment strategies for SAN diseases.MethodsA goat model of SND was developed (n = 10) by epicardially ablating the SAN and validated by mapping of emergent SAP locations through an ablation catheter and surface electrocardiogram (ECG). Structural characterization of the goat SAN and SAP was assessed by histology and immunofluorescence techniques.ResultsWhen the SAN was ablated, SAPs featured a shortened atrioventricular conduction, consistent with the location in proximity of atrioventricular junction. SAP recovery time showed significant prolongation compared to the SA...

2018 Computing in Cardiology Conference (CinC), 2018

Diagnosis of heart disease and its treatment are based largely on our understanding of the electrophysiology of adult myocardium. However, the marked difference in the electrical action potential (AP)between neonatal and adult cardiac myocytes suggests a different set of molecular bases in neonatal myocytes, and therefore different treatment for new-borns. In this study we present a new mathematical model of sinoatrial node (SAN) cells of the neonatal rabbit, by modifying densities or kinetics of INa, ICaL, If, IKr, IKs, and INaCa in the adult rabbit SAN cell models developed by Zhang et al., based on available experimental data obtained from new-born rabbit SAN cells. The new model reproduced APs similar to experimental recordings from neonatal myocytes, with a faster pacemaking rate. Using the new model, we investigated how age-related changes in ionic currents modulate pacemaking AP morphology, demonstrating the model as a useful tool for testing the effects of drugs on neonatal ...

Pacing and Clinical Electrophysiology, 1990

IWNW, 2024

Discussion of the beer industry in the Fayum village of Euhemeria with an edition of P.Fay. 215 descr. and a correction to BGU XI 2032.