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2017, Brain topography
The article by Hashemiyoon et al. is a masterful synthesis of the clinical, genetic, and neurobiological aspects of Gilles de la Tourette's syndrome that provides unique insights into the neural state dysfunctions that underlie this enigmatic disorder. In particular, the authors make a powerful argument for the disorder arising from hyposynchronization within cortico-basal ganglia-thalamocortical systems which may result from a genetically-driven developmental insult to interneuron regulation, and suggest deep brain stimulation as a valuable tool to assess how balance may be restored to the system and reverse the pathological state.
Journal of Child and Adolescent Psychopharmacology
Neurobiological Substrates of Tourette's Disorder2010 •
F1000Research
Tourette syndrome research highlights from 2016This article presents highlights chosen from research that appeared during 2016 on Tourette syndrome and other tic disorders. Selected articles felt to represent meaningful advances in the field are briefly summarized.
Journal of Pharmaceutical Research International
Understanding the Pathophysiology of Tourette’s Syndrome: A ReviewTourette’s syndrome (TS) is a neuropsychiatric and neurodevelopment disease typified by deterioration of motor and vocal tics which leads to neuropsychiatric symptoms and impaired motor activities manifestation. Several lines of study indicate the interplay of genetic and environmental factors to be involved in this complex neuropsychiatric syndrome. Approximately 1% people are affected worldwide from this syndrome. In this review, a concise outline presented on the classification, its clinical features and neuropsychiatric co-morbidities linked with this syndrome. This paper also highlights the neurochemistry, dysfunction of (Cortioc-Striato-Thalamo-Cortical) CSTC circuits in TS and an overview on the management approach towards the prevention of TS. Regardless of the major improvements in the understanding of exact cellular and molecular basis of TS, the various evidence indicate that the various neurotransmitter such as dopamine, glutamate, gamma- aminobutyric acid (GABA), seroto...
Frontiers in Neuroscience
Addressing the Complexity of Tourette's Syndrome through the Use of Animal Models2016 •
Experimental Brain Research
Non-invasive brain stimulation as therapy: systematic review and recommendations with a focus on the treatment of Tourette syndromeTourette syndrome (TS) is a neurodevelopmental condition characterised by tics, which are stereotyped movements and/or vocalisations. Tics often cause difficulties in daily life and many with TS express a desire to reduce and/or gain control over them. No singular effective treatment exists for TS, and while pharmacological and behavioural interventions can be effective, the results are variable, and issues relating to access, availability and side effects can be barriers to treatment. Consequently, over the past decade, there has been increasing interest into the potential benefits of non-invasive brain stimulation (NIBS) approaches. This systematic review highlights work exploring NIBS as a potential treatment for TS. On balance, the results tentatively suggest that multiple sessions of stimulation applied over the supplementary motor area (SMA) may help to reduce tics. However, a number of methodological and theoretical issues limit the strength of this conclusion, with the most ...
Movement disorders : official journal of the Movement Disorder Society
Selective dysfunction of basal ganglia subterritories: From movement to behavioral disorders2015 •
NeuroImage. Clinical
Altered intrahemispheric structural connectivity in Gilles de la Tourette syndrome2014 •
European Neurology
Issues Related to Deep Brain Stimulation for Treatment-Refractory Tourette’s Syndrome2009 •
Frontiers in Neurology
PET Neuroimaging: Insights on Dystonia and Tourette Syndrome and Potential Applications2014 •
2009 •
Acta Neurochirurgica
Deep brain stimulation therapy for treatment-refractory Tourette’s syndrome2011 •
Harvard Review of Psychiatry
Gamma Oscillation Deficits and the Onset and Early Progression of Schizophrenia2010 •
Neuroscience Research - NEUROSCI RES
Decreased Number of Parvalbumin and Cholinergic Interneurons in the Striatum of Individuals with Tourette Syndrome2009 •
Neuroscience & Biobehavioral Reviews
Deep brain electrophysiological recordings provide clues to the pathophysiology of Tourette syndrome2013 •
The Journal of neuropsychiatry and clinical neurosciences
Neurobiology of the Premonitory Urge in Tourette's Syndrome: Pathophysiology and Treatment Implications2017 •
2014 •
2009 •
2013 •
PLoS ONE
Repetitive Behaviours in Patients with Gilles de la Tourette Syndrome: Tics, Compulsions, or Both?2010 •
2010 •
Movement Disorders
Split-screen video demonstration of sonography-guided muscle identification and injection of botulinum toxin2010 •
Journal of Neuroscience
Nucleus Accumbens Deep Brain Stimulation Produces Region-Specific Alterations in Local Field Potential Oscillations and Evoked Responses In Vivo2009 •
Journal of Neurology, Neurosurgery & Psychiatry
Image-based analysis and long-term clinical outcomes of deep brain stimulation for Tourette syndrome: a multisite studyBehavioural Neurology
Selection of Patients with Tourette Syndrome for Deep Brain Stimulation Surgery2013 •
2011 •
Scientific reports
Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders2016 •
Movement disorders : official journal of the Movement Disorder Society
Tourette syndrome deep brain stimulation: A review and updated recommendations2014 •
Tremor and other hyperkinetic movements (New York, N.Y.)
Tourette syndrome and consciousness of action2013 •
The Lancet. Neurology
Bilateral globus pallidus stimulation for severe Tourette's syndrome: a double-blind, randomised crossover trial2015 •
Journal of the American Academy of Child & Adolescent Psychiatry
Tourette Syndrome and Tic Disorders: A Decade of Progress2007 •
Journal of Developmental and Behavioral Pediatrics
Developmental and Behavioral Disorders Grown Up2008 •
Journal of Developmental and Behavioral Pediatrics
Developmental and Behavioral Disorders Grown-Up—Intellectual Disability2010 •