Academia.edu no longer supports Internet Explorer.
To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade your browser.
Acta Neuropathologica
Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders1994 •
Reviews in the Neurosciences
Microcirculation of the brain: morphological assessment in degenerative diseases and restoration processes2015 •
Alzheimer’s disease (AD) is the leading cause of dementia worldwide. It compromises patients’ daily activities owing to progressive cognitive deterioration, which has elevated direct and indirect costs. Although AD has several risk factors, aging is considered the most important. Unfortunately, clinical diagnosis is usually performed at an advanced disease stage when dementia is established, making implementation of successful therapeutic interventions difficult. Current biomarkers tend to be expensive, insufficient, or invasive, raising the need for novel, improved tools aimed at early disease detection. AD is characterized by brain atrophy due to neuronal and synaptic loss, extracellular amyloid plaques composed of amyloid-beta peptide (Aβ), and neurofibrillary tangles of hyperphosphorylated tau protein. The visual system and central nervous system share many functional components. Thus, it is plausible that damage induced by Aβ, tau, and neuroinflammation may be observed in visua...
Frontiers in Aging Neuroscience
Magnetic Resonance Q Mapping Reveals a Decrease in Microvessel Density in the arcAβ Mouse Model of Cerebral Amyloidosis2016 •
The American Journal of Pathology
Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease Mutations2010 •
International Journal of Developmental Neuroscience
Effect of VEGF and its receptor antagonist SU-5416, an inhibitor of angiogenesis, on processing of the β-amyloid precursor protein in primary neuronal cells derived from brain tissue of Tg2576 mice2010 •
A large number of Alzheimer patients demonstrate cerebrovascular pathology, which has been assumed to be related to β-amyloid (Aβ) deposition. Aβ peptides have been described to inhibit angiogenesis both in vitro and in vivo, and deregulation of angiogenic factors may contribute to various neurological disorders including neurodegeneration. One of the key angiogenic factor is the vascular endothelial growth factor (VEGF). Increased levels of VEGF have been observed in brains of Alzheimer patients, while the functional significance of VEGF up-regulation in the pathogenesis and progression of AD is still a matter of debate. To test whether VEGF may affect neuronal APP processing, primary neuronal cells derived from brain tissue of E16 embryos of Tg2576 mice were exposed with 1 ng/ml VEGF for 6, 12, and 24h, followed by monitoring formation and secretion of soluble Aβ peptides, release of the human APP cleavage products, sAPPβswe and sAPPα, into the culture medium as well as the activities of α- and β-secretases in neuronal cell extracts. Exposure of primary neuronal cells by VEGF for 24h led to slightly reduced sAPPβ release, accompanied by decreased β-secretase activity 12h after VEGF exposure. Incubation of neurons by the VEGF receptor antagonist and angiogenesis inhibitor SU-5416 for 24h resulted in increased release of sAPPβswe, and strikingly enhanced secretion of Aβ peptides into the culture medium, which was accompanied by a significant increase in β-secretase activity, as compared to control incubations. The SU-5416-induced effects on APP processing could not be suppressed by the additional presence of VEGF, suggesting that SU-5416 affects pathways that are apparently independent of VEGF receptor signaling. The data obtained indicate that VEGF-driven mechanisms may affect APP processing, suggesting a link of angiogenesis and pathogenesis of Alzheimer's disease.
Acta Neuropathologica
Age-related microvascular degeneration in the human cerebral periventricular white matter2006 •
Brain pathology (Zurich, Switzerland)
Cerebral hypoperfusion and the energy deficit in Alzheimer's disease2016 •
There is a perfusion deficit in Alzheimer's disease (AD), commencing in the precuneus and spreading to other parts of the cerebral cortex. The deficit anticipates the development of dementia, contributes to brain damage, and is caused by both functional and structural abnormalities of the cerebral vasculature. Most of the abnormalities are probably secondary to the accumulation of Aβ but the consequent hypoperfusion may, in turn, increase Aβ production. In the early stages of disease, abnormalities that cause vasoconstriction predominate. These include cholinergic vascular denervation, inhibition of endothelial nitric oxide synthase, increased production of endothelin-1 production and possibly also of angiotensin II. Patients with AD also have an increased prevalence of structural disease of cerebral microvessels, particularly CAA and capillary damage, and particularly in the later stages of disease these are likely to make an important contribution to the cerebral hypoperfusion...
NeuroImage : Clinical
Quantitative histomorphometry of capillary microstructure in deep white matter2019 •
Journal of The Neurological Sciences
Morphological substrates of cognitive decline in nonagenarians and centenarians: A new paradigm?2007 •
Acta Neuropathologica Communications
Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer’s diseaseNeuropathology and Applied Neurobiology
The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and Alzheimer's disease2013 •
Journal of Neuropathology and Experimental Neurology
Stereologic Analysis of Microvascular Morphology in the Elderly2006 •
Journal of Neuroscience
Contrast-Enhanced Magnetic Resonance Microangiography Reveals Remodeling of the Cerebral Microvasculature in Transgenic ArcA Mice2012 •
Alzheimer's & Dementia
Microvascular network alterations in the retina of patients with Alzheimer's diseaseNeurobiology of Aging
Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances2009 •
Journal of Neuroscience
Impaired Orthotopic Glioma Growth and Vascularization in Transgenic Mouse Models of Alzheimer's Disease2010 •
Brain : a journal of neurology
Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment2016 •
Brain Research Reviews
Evidence that Alzheimer's disease is a microvascular disorder: the role of constitutive nitric oxide2000 •
Journal of the neurological sciences
Post-mortem 7.0-tesla magnetic resonance study of cortical microinfarcts in neurodegenerative diseases and vascular dementia with neuropathological correlates2014 •
Brain research …
The impact of vascular burden on late-life depression2009 •
American Journal of Medical Sciences and Medicine
Reduced Capillary Density in the Prefrontal Cortex in Schizophrenia2013 •
Acta Neuropathologica
Assessing the cognitive impact of Alzheimer disease pathology and vascular burden in the aging brain: the Geneva experience2006 •
2010 •
Microcirculation
Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with Liraglutide ™2014 •
Neuropharmacology
Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease2009 •
Journal of the Neurological Sciences
Effect of APOE genotype on microvascular basement membrane in Alzheimer's disease2002 •
British Medical Bulletin
The relationship between type 2 diabetes and dementia2008 •
Proceedings of the National Academy of Sciences of the United States of America
Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease2018 •
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Exploring neurodegenerative disorders using a novel integrated model of cerebral transport: Initial results2004 •
Neurobiology of Aging
Microvascular injury and blood–brain barrier leakage in Alzheimer's disease2007 •
Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine
Role of Vascular Risk Factors and Vascular Dysfunction in Alzheimer's Disease2010 •
2013 •
Brain Research Reviews
Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply2003 •
2011 •
Neuroscience
Nitric oxide in the cerebral cortex of amyloid-precursor protein (SW) Tg2576 transgenic mice2004 •
Journal of Aging Research
Neurobiology of Vascular Dementia2011 •