ORIGINAL ARTICLE
Microvascular Free Flap Reconstructive Options in
Patients With Partial and Total Maxillectomy Defects
Rudy J. Triana, Jr, MD; Vedran Uglesic, MD; Miso Virag, MD; Sinisa G. Varga, DDS; Predrag Knezevic, MD;
Aleksandar Milenovic, MD; Naranja Aljinovic, MD; Craig S. Murakami, MD; Neal D. Futran, MD, DMD
Objective: To evaluate and discuss the free flap reconstructive options for patients with partial and total maxillectomy defects.
Design: Retrospective review of cases.
Setting: Two tertiary referral centers.
Patients: Fifty-one patients had partial or total maxil-
lectomy defects resulting from oncologic surgical resection, and 7 had partial maxillectomy defects resulting from
trauma. Inferior or partial maxillectomy defects included 10 anterior arch and hemipalate defects and 12
subtotal or total palate defects. Total maxillectomy defects with and without orbital exenteration included 36
maxilla defects with hemipalate and malar eminence.
Intervention: There were 11 fibula, 14 rectus abdominis, 9 scapular, 10 radial forearm, 5 latissimus dorsi, and
13 combination latissimus dorsi and scapular flaps.
Main Outcome Measures: Separation of the oral cav-
ity from the sinonasal cavities, diet, type of dental restoration, type of orbital restoration, speech intelligibility, and complications.
From the Department of
Otolaryngology–Head and
Neck Surgery, University of
North Carolina at Chapel Hill
School of Medicine, Chapel Hill
(Dr Triana); the Department
of Otolaryngology–Head and
Neck Surgery, Wake Medical
Center, Raleigh, NC
(Dr Triana); the Department
of Maxillofacial Surgery,
University of Zagreb School
of Medicine, Zagreb, Croatia
(Drs Uglesic, Virag, Varga,
Knezevic, Milenovic, and
Aljinovic); and the Departments
of Otolaryngology–Head and
Neck Surgery, Virginia Mason
Clinic (Dr Murakami) and
University of Washington
School of Medicine
(Dr Futran), Seattle, Wash.
Results: Only 1 flap failure was reported. There was loss
of bone in 2 flaps and loss of the skin paddle in 1 flap.
All palatal defects were sealed by the separation of the
oral and sinonasal cavities. Thirty-eight patients were able
to eat a regular diet while the remaining patients maintained a soft diet. All patients conversed on the telephone without difficulty in intelligibility. Eight patients
had an implant-borne dental prosthetic, and 30 patients
had a conventional partial prosthetic. Orbit restoration
was achieved in 2 patients with an implant-borne prosthetic, and 6 patients retained a standard orbit prosthetic.
Conclusions: Free flap reconstruction of the maxilla cre-
ates reproducible permanent separation of the oral and
sinonasal cavities in a single-stage procedure. In addition, there exists the potential for dental rehabilitation
with restoration of masticatory and phonatory function.
Free flap reconstruction also provides a good cosmetic
result, which improves patients’ outlook and contributes to their overall well-being. Reconstructive flaps are
designed to fit specific maxillary defects and patient needs
to provide optimally functional and cosmetic results.
Arch Facial Plast Surg. 2000;2:91-101
T
UMORS of the maxilla involve 2 main sites: the palate (oral cavity) and the
maxillary sinus. Malignancies of the paranasal sinuses represent 0.2% of all malignancies
and 3% of all cancers of the upper aerodigestive tract. Tumors of the palate represent 8% of oral cavity cancers and 5%
of all upper aerodigestive tract malignancies.1,2
Treatment of these tumors usually requires a combination of surgical extirpation followed by radiation therapy. The resultant defects involve the disruption of
the soft and bony tissues of the palate and
midface. Loss of these key structures has
significant functional and cosmetic consequences. These consequences may include the creation of large oronasal and
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oromaxillary fistulae, loss of significant
tooth-bearing segments (which may impair oral alimentation and speech), loss of
lip and cheek support, and loss of midface projection.3
Traditionally, these defects were reconstructed using skin grafts to line the
postresection cavity and using some type
of bulky dental obturative prosthesis. By
using an obturator, the oral and sinonasal cavities can be separated. However, the
patients are required to use the prosthesis for speaking and swallowing. The prosthesis must be removed and cleaned on a
regular basis.4,5 Several different surgical
options to seal the palate, separating the
oral and nasal cavities, have been described.6-10 These include local palatal, pharyngeal, and nasal septal flaps for small defects, and temporalis, forehead, and distant
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PATIENTS AND METHODS
We evaluated a retrospective series of 58 patients who
underwent free flap reconstruction of the maxilla at
the University of Washington, Seattle, and the University of Zagreb, Zagreb, Croatia, between January
1, 1993, and December 31, 1998. Defects were classified as inferior or partial maxillectomy, including
defects of the hemipalate and anterior arch; inferior
or partial maxillectomy with subtotal or total palate
defects; and total maxillectomy with and without orbital exenteration (Figure 1 and Figure 2). Plans
for palatal, dental, and orbital rehabilitation were made
preoperatively by the oral and maxillofacial prosthedontist.
Patient follow-up ranged from 3 months to 5
years. The type of defect, free flap(s) used in the reconstruction, and complications were identified for
each patient. In addition, closure between the sinonasal and oral cavities, type of diet, and type of dental restoration were examined in each patient. Orbit
restoration in patients who had total maxillectomy
with orbital exenteration was identified. Speech was
evaluated, and the findings were based on the patient’s ability to converse intelligibly on the telephone.
tubed flaps, typically used for larger defects. These techniques, however, have been limited by the amount of tissue available and/or pedicle length.
Microvascular free tissue transfer has been described as a unique alternative for reconstruction of the
palate, midface, and maxilla. Microvascular free tissue
reconstruction allows for the transfer of adequate amounts
of soft tissue and bone in a single-stage procedure, without the limitations of pedicle length or flap geometry. A
variety of free tissue transfers have been used for palate,
midface, and maxilla reconstruction, including scapula,11-14
fibula,15-21 radial forearm,22-25 rectus abdominis,26,27 iliac
crest,13,14,28 and latissimus dorsi29,30 flaps. In this article,
we present a series of patients with various maxillectomy defects who underwent free flap reconstruction. We
describe successful separation of oral and sinonasal cavities, complications, types of oral diet, dental rehabilitation, and speech intelligibility. We evaluate the success
of these techniques with specific case presentations and
identify factors that may aid in the selection of flaps for
specific maxillectomy defects.
RESULTS
Forty-two patients underwent primary reconstruction at
the time of tumor resection; 5 patients underwent primary reconstruction within several days following their
facial injury; and 11 patients underwent secondary reconstruction. Of the 58 patients, 2 had sustained a past
facial injury with subsequent soft tissue and bone defect. There were 10 patients with inferior or partial maxillectomy defects involving the hemipalate and/or the anterior arch. Twelve patients had inferior or partial
A
B
C
D
Figure 1. A, Anteroposterior view of an inferior partial maxillectomy defect.
B, Lateral view of the defect in A. Hatched lines indicate more of the
hemipalate that could be resected (also includes anterior arch defects).
C, Anteroposterior view of an inferior partial maxillectomy defect with total
palate defect. D, Lateral view of the defect in C.
A
B
C
D
Figure 2. A, Anteroposterior view of a total maxillectomy defect. Hatched
lines indicate the amount of additional malar bone and zygomatic arch that
could be included in the resection. B, Lateral view of the defect in A.
C, Anteroposterior view of a total maxillectomy defect with orbital
exenteration. Hatched lines indicate additional malar bone and zygomatic arch
that could be included in the resection. D, Lateral view of the defect in C.
maxillectomy defects involving a subtotal or total palate
defect. There were 36 patients with total maxillectomy
defects including the hemipalate and malar eminence. Of
the 36 patients, 25 underwent orbital exenteration with
maxillectomy, and 11 did not. Table 1 lists the characteristics of the patient population, matching defect type
with age, sex, and diagnosis.
Postsurgical defect and free flap choice are presented in Table 2. For inferior maxillectomy palatal
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Table 1. Demographics and Diagnosis of 58 Patients Who Underwent Microvascular Free Flap Reconstructive Surgery
Total Maxillectomy
Inferior Maxillectomy
Characteristics
Partial With Hemipalate
or Partial Palate Defect
With Subtotal
or Total Palate Defect
Without Orbital
Exenteration
With Orbital
Exenteration
10
52 (16-78)
7/3
12
49 (28-66)
9/3
11
44 (28-65)
8/3
25
57 (23-86)
15/10
1
1 (Palate),
2 (maxillary sinus)
0
0
0
0
0
0
2
1
1
0
21 (Maxillary sinus)
No. of patients
Age, y, mean (range)
Male/female, No.
Diagnosis, No.
Gunshot wound
Squamous cell carcinoma
Adenocarcinoma
Verrucous carcinoma
Mucoepidermoid carcinoma
Carcinoma x pleomorphic adenoma*
Adenoid cystic carcinoma
Basal cell carcinoma (face with bony invasion)
Osteogenic carcinoma (maxillary sinus)
Fibrosarcoma (maxillary sinus)
Melanoma (maxillary sinus)
4
2 (Palate)
2
7
1
1
1
1
0
0
0
0
0
1
0
0
0
1
1
0
0
0
0
0
0
0
1 (Maxillary sinus)
2
1
0
0
*x indicates tumor changed from benign to malignant.
Table 2. Free Flaps and Defects in 58 Patients Who Underwent Microvascular Free Flap Reconstructive Surgery
Inferior Maxillectomy
Total Maxillectomy
Partial With Hemipalate
or Partial Palate Defect
With Subtotal or Total Palate
Defect (Midface Defect)
Without Orbital
Exenteration
With Orbital
Exenteration
10
10
12
14*
11
11
25
26†
8
2
6
2
1
1
2
0
2
0
0
0
Fibula (osteocutaneous)
Scapula (osteocutaneous)
Latissimus dorsi
0
0
0
11
2
0
0
0
0
3
0
2 (With cranial bone grafts)
1 (Without cranial bone
grafts)
0
6
5 (Myocutaneous)
Combination‡
0
0
0
0
0
9
0
5 (With cranial bone grafts)
4 (Without cranial bone
grafts)
0
1
1 (With scapula
[osteomyocutaneous])
0
No. of patients
No. of free flaps
Type of flap, No.
Radial forearm
Osteocutaneous
Fasciocutaneous
Rectus abdominis
Myofacial
Myocutaneous
12
*Two patients required 2 free flaps to reconstruct the defect.
†One patient required reconstruction with 2 free flaps.
‡Latissimus dorsi (myocutaneous) with scapula (osteocutaneous).
defects, decisions to use a bone-containing flap were
based on the quality and position of the patient’s
residual dentition and/or denture-bearing alveolar arch.
All 12 patients with subtotal and total palate defects
received bone-containing free flaps; 2 of these patients
required an additional free flap (radial forearm) to
cover a soft tissue defect of the face. In patients who
underwent a total maxillectomy, 20 of the 36 received a
bone-containing flap to reconstruct both the malar
eminence and alveolar ridge, and 16 received a soft tissue flap. Of the 16 patients, bone reconstruction was
performed at the time of the free flap reconstruction
(soft tissue) using cranial bone grafts in 7. Cranial
bone was primarily used to reconstruct the orbital
floor and malar eminence. The use of different myocutaneous and myofascial flaps was based on the volume
of the soft tissue defect and the surgeon’s preference.
Improved aesthetic contour was achieved when using
a bone-containing flap, specifically in those patients
with anterior arch defects who needed better support
of the upper lip and in those who had a loss of the
malar eminence.
Vein grafts were needed in 9 of the 12 subtotal or total palate defects that were reconstructed with bonecontaining flaps: 11 fibula and 1 scapula. In these cases,
the vein grafts were needed to allow the flap pedicle to reach
the recipient neck vessels. Vein grafts were not needed for
the free flaps used for the total maxillectomy defects.
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Table 3. Complications Following Microvascular
Free Flap Reconstructive Surgery in 58 Patients
Table 4. Functional Results in 58 Patients Who Underwent
Microvascular Free Flap Reconstructive Surgery*
No. of
Patients
Complication
Flap failure
Partial flap failure with loss of bone or skin
Return to operating room for flap salvage
Wound infection and dehiscence
Donor site hematoma
Neck hematoma and seroma
Postoperative pneumonia
Postoperative meningitis
Postoperative death (within 1 mo)
1
3
5
3
1
3
3
1
1
Five flaps required urgent return to the operating
room on the first postoperative day: 3 for arterial compromise and 2 for venous compromise (Table 3). In both
cases of venous compromise, poor pedicle geometry was
identified. Proper vessel alignment was achieved and venous outflow restored. In the cases of arterial compromise, one patient disrupted the arterial anastomoses upon
awakening from anesthesia. This was quickly recognized, the neck opened, the anastomosis revised, and the
flap saved. In the other 2 cases, arterial compromise was
suspected because of apparent partial loss of the skin
paddle of these 2 flaps (1 scapula and 1 fibula). In each
of these cases, the anastomosis was evaluated and found
to be patent. The partial skin loss was attributed to poor
skin perforators of these 2 flaps. In the case of the fibula
flap, the skin loss was in the area of the palate. The patient was returned to the operating room 10 days following the first reconstructive procedure, and a radial forearm flap was used to line the palate (Table 2). There were
2 cases of scapula–latissimus dorsi (osteomyocutaneous) flaps that exhibited delayed bone loss requiring operative debridement; the wounds completely healed. There
was 1 case of complete flap failure in this series that involved a scapula flap (osteocutaneous) that failed within
the first postoperative week and was replaced with a latissimus dorsi (myocutaneous) flap. Other complications
included 1 neck hematoma, 1 donor site hematoma, and
2 neck seromas that were drained percutaneously at the
bedside and resolved without complication (Table 3).
Three patients developed partial dehiscence of the
palate wound within 10 days of the reconstructive procedure. Two patients were treated with local wound care
and were subsequently returned to the operating room
for delayed wound closure, one on postoperative day 14
and one on postoperative day 22. Both wounds healed
completely, although 1 wound healed by secondary intention. Postoperative pneumonia occurred in 3 patients. Two cases resolved with intravenous antibiotic
therapy. One patient developed a pneumothorax and a
pulmonary abscess and died after 2 months in the hospital. One patient developed meningoencephalitis, which
resolved with intravenous antibiotic therapy, but left the
patient with significant functional deficits.
Functional results are presented in Table 4. The
data represent those patients with a minimum of 6 months
of follow-up after the primary reconstructive proce-
No. of
Patients (%)
Functional Result
Closure between sinonasal and oral cavity
Diet (n = 56)
Regular
Soft
Speech (n = 56)
Ability to be understood in telephone conversation
Dental restoration (n = 56)
Implant-borne prosthesis
Conventional partial prosthesis
None
Orbit restoration (n = 25)†
Implant-borne prosthesis
Conventional orbital prosthesis
58 (100)
37 (66)
19 (34)
56 (100)
9 (16)
30 (54)
17 (30)
2 (8)
6 (24)
*Two patients died, 1 and 2 months postoperatively.
†Of the 25 patients who underwent a total maxillectomy with orbital
exenteration, only 8 underwent orbit restoration.
dure. All 58 patients had wound closure and successful
separation between the oral and sinonasal cavities. Of the
56 patients who lived, 37 were able to eat a regular diet
and 19 were able to eat a soft diet. Although formal speech
evaluations were not performed, 56 patients were able
to be understood on the telephone.
Dental rehabilitation is described in Table 4. Nine patients had placement of osseointegrated implants. In 2 patients with partial palate defects, the implants were placed
in the remaining native bone, and they were able to wear
an implant-borne prosthesis. In the other 7 patients, those
with subtotal or total palate defects, osseointegrated implants were placed into the free flap bone, which supports
an implant-borne prosthesis. Thirty patients were able to
wear a conventional partial prosthesis, and 17 patients did
not choose dental rehabilitation.
Orbit restoration is presented in Table 4. Of the 25
patients who underwent a total maxillectomy with orbital exenteration, 2 had implant-borne orbital prostheses and 6 were able to use a conventional prosthesis. The
majority (n=21) of total maxillectomies with orbital exenteration were performed in Croatia, and financial limitations may account for the low number of patients receiving any form of orbit restoration. Financial limitations
also restricted the use of osseointegrated implants for dental restoration in the Croatian patients, even though bonecontaining flaps were implanted.
COMMENT
Reconstruction of partial and total maxillectomy defects may have variable soft tissue and bony requirements, which are determined by the extent of the resection. Many of these defects result in significant functional
and aesthetic sequelae. These may include collapse of the
lip, cheek, and infraorbital soft tissues, loss of the hemipalate with compromise of the oral phase of swallowing, difficulty with speech articulation, and orbital complications.31 In some cases in which the globe is spared,
the lack of infraorbital rim and orbital floor support can
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result in hypophthalmos, enophthalmos, vertical dystopia, diplopia, and ectropion.32 The goals of reconstructing defects of the maxilla include (1) consistently obtaining a healed wound; (2) restoring palatal competence
and function (separation of oral and sinonasal cavities);
(3) supporting the orbit or filling the orbital cavity in cases
of exenteration; (4) obliterating the maxillectomy defect; and (5) restoring facial contours.33
The traditional method of reconstructing palatal and
maxillary defects involves a split-thickness skin graft to
line the defect cavity and placement of an obturator (prosthesis) to seal the palate and separate the oral and sinonasal cavities.4,5,34,35 The advantages include a shorter operative case following the reconstruction and the ability
for the oncologic surgeon to follow the wound cavity for
tumor recurrence. To date, there are no studies in the
literature documenting any increased delay in detection
of recurrent tumors in patients undergoing some type of
reconstruction of a maxillectomy defect.1,36 In fact, advanced imaging techniques, such as computed tomography and magnetic resonance imaging, have aided the
oncologic surgeon in detecting tumor recurrence earlier in these areas.37 The obvious disadvantages of an obturator are the inherent problems of leakage, cleaning,
and repeated prosthesis refinement. Elderly patients or
those patients with impaired manual dexterity and poor
vision may find it exceptionally difficult to clean, maintain, and manipulate the prosthesis.38 As the wound heals,
usually in the presence of postoperative radiotherapy, the
prosthesis often becomes loose. This results in leakage
of food and secretions into the nasal cavity and creates
further problems with speech and oral hygiene.
Surgical management of these defects and their functional problems originally involved the use of a variety
of pedicled autogenous tissues. In the 19th century, von
Langenbeck39 described the use of local palatal flaps for
reconstructing small defects. For larger palatal and maxillary defects, the pharyngeal, forehead, temporalis, and
distant flaps (such as the deltopectoral and upper arm
flaps) have been used.6-10,31,40,41 Vascularized cranial bone
grafts also have been used in a small series of patients.
Most of the success of these procedures has been in reconstructing isolated, limited defects such as the orbital
floor and rim, or zygomatic and malar complexes.42-44
However, each of these techniques is limited by a paucity of tissue to fill the defect, by the length of the vascular pedicle, and/or by the need for multiple stages to
achieve a final result.
With the advent of microvascular free tissue transfer, most large defects (postoncologic resection or posttraumatic) of the palate, maxilla, and midface can be reconstructed with a single-stage procedure. Abundant soft
tissue and bone can be transferred without limitations
of vascular pedicle length or tissue orientation.30,45
A variety of donor sites have been described in the
literature. In 1987, MacLeod et al22 reported 3 cases of
palatal fistulae reconstructed with radial forearm free flaps
with and without bone. In 1992, Chen et al46 reported 4
cases of palatal fistulae that were closed with a radial forearm free flap. In both studies, all patients had palatal fistulae following a failed cleft palate repair; closure of the
fistulae occurred in all 7 patients. Hatoko et al23 de-
scribed 3 palatal defects following tumor ablation that
were successfully closed with a fasciocutaneous radial forearm free flap; 2 of these patients were able to use a dental prosthesis. More recently, McLoughlin et al47 used an
osteocutaneous radial forearm free flap to reconstruct the
orbital rim and soft tissues of the cheek, and to obliterate the maxillary sinus cavity. In 1998, Cordeiro et al24
described the “sandwich” radial forearm osteocutaneous free flap for reconstruction of the subtotal maxillectomy defect. The bone was used to recreate the maxillary arch with the skin paddle folded around it, allowing
both the palatal and nasal linings to be restored. Both patients refused osseointegrated implants, and both used
dentures and maintained a regular diet. In addition, both
patients had near normal speech and had an acceptable
aesthetic result without retraction of the upper lip.23
Larger case series of palatal and maxillary defects
reconstructed with myocutaneous free flaps, primarily
the latissimus dorsi and rectus abdominis, have been reported. Shestak et al29,30 found the latissimus dorsi free
flap to be very versatile. In all of the patients in the study,
the palates were sealed and an aesthetically satisfactory
recontouring of the face and cheek soft tissues was
achieved. In addition, the ample pedicle length allowed
microvascular anastomoses in the neck without the need
for vein grafts. The rectus abdominis free flap demonstrates similar flap attributes and similar postoperative
results.26,27,48 Olsen et al27 described a series of 11 patients with massive sino-orbital defects, achieving success using the rectus abdominis free flap in 9. Of the 11
patients, 6 had successful reconstruction of the palate,
and all patients exhibited excellent speech and deglutition. In a similar study, Yamamoto et al48 described the
use of the “boomerang” rectus abdominis free flap. The
skin paddle is designed in the shape of a boomerang, allowing each leaf to be folded into its respective defect,
that is, orbit and palate or orbit and soft tissues of the
cheek.
The majority of studies recommending free tissue
transfers for maxillary reconstruction describe the use
of the scapula osteocutaneous flap.11-13,49-52 This flap is
advantageous in that the soft tissue component can be
rotated around the bone stock with greater freedom than
the other composite flaps. It is particularly useful in defects in which both the orbital floor–zygomatic arch and
palate need to be reconstructed. If the angular branch of
the thoracodorsal vessel is included in the flap harvest,
both the tip and the lateral border of the scapula can be
harvested. When appropriate osteotomies are made, the
palate and infraorbital regions can be restored.53 Uglesic
et al36 described an osteomyocutaneous free flap based
on the subscapular system of flaps for reconstruction of
the total maxillectomy defect with orbital exenteration.
This type of flap has good bone stock that can be used
for the infraorbital area and palate, a muscle component
(latissimus dorsi) for cavity obliteration, and a skin component for filling soft tissue deficits of the midface, cheek,
and palate.
Another free flap option that provides an adequate
volume of bone for palatal reconstruction and midface
support is the fibula free flap. Multiple case studies describe the ease with which the flap can be harvested, the
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A
B
C
D
Figure 3. A, A preoperative anterior arch defect, partial upper lip defect, and total rhinotomy following resection of a squamous cell carcinoma involving the nasal
vestibule. B, A radial forearm (osteocutaneous) free flap was inset to recreate the anterior arch. C, The palate defect was closed with a portion of the skin paddle,
while the remaining skin was used to line the nose. D, Postoperative result, showing closure and separation of the nasal-oral cavities and nasal prosthesis in place.
excellent bone stock, and the soft, pliable skin paddle that
can be used for either intraoral or cutaneous reconstruction. In addition, the vascular pedicle may be lengthened to avoid the possible need for vein grafts.15-20,54
Three patients received implant-borne dentures in these
studies.16,20,54
The iliac crest free flap provides an excellent bone
source for palate and maxillary reconstruction. Brown28
presented 3 cases of palatal reconstruction using this flap
and reported favorable functional results. Others have discouraged the use of the iliac crest free flap in the maxilla
because of its excessive bulk, poor skin paddle mobility
in relationship to bone, and short pedicle length.14
Finally, some authors advocate the use of dual free
flaps to reconstruct these complex defects.21,25 Although
success has been observed in a small series of patients,
the advantages of 2 separate free flaps have not been demonstrated. This complex and time-consuming effort has
not been proven to be more beneficial than the use of a
properly designed single free flap in providing excellent
bone stock and pliable soft tissue.
Schusterman et al13 recommended a bone-containing
free flap for maxillary reconstruction when bony support was needed and previous irradiation precluded the
use of nonvascularized grafts. Cordeiro et al32 showed the
successful use of nonvascularized bone grafts to recon-
struct the orbital floor in conjunction with a vascularized free flap of soft tissue in patients with total maxillectomy defects. Coleman14 emphasized the importance
of functional reconstruction when addressing defects of
the midface and the orbits. The loss of bone support of
the midface, either from oncologic resection or trauma,
results in the contraction of the wound, with forces pulling toward the center of the defect during healing. The
needs of the wound (ie, skin, soft tissue, mucosa, and
bone) need to be carefully matched to the characteristics of the appropriate flap prior to undertaking the reconstructive procedure. These factors include the length
of the vascular pedicle; the thickness or thinness of skin,
muscle, and subcutaneous fat; the volume of the soft tissue available; the durability and thickness of bone; and
donor site morbidity.
Davison et al35 recommended free tissue transfer closure of maxillectomy defects when substantial associated
sino-orbital and/or soft tissue defects existed. They concluded their review, however, by stating “refinement of
microsurgical techniques with free vascularized bone may
provide an ideal answer in providing surgical reconstruction that could support an implant-borne prosthesis.” As
microsurgical techniques have become more refined, much
more attention has been given to the function and aesthetics of this complex wound closure.
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A
B
C
D
E
F
Figure 4. A, A total palatectomy specimen following resection of an invasive squamous cell carcinoma of the right lateral hard palate (right side, inferior). B, Fibula
(osteocutaneous) free flap with vein graft. C, The palate 6 months following completion of radiation therapy. It is closed, and osseointegrated implants have been
placed in the fibula. D, Dental rehabilitation is complete, with implant-borne prosthesis in place. E and F, Postoperative results, showing good anterior arch and
midface projection.
In a series of maxillary reconstructions using primarily the rectus abdominis flap, Olsen et al27 reported
acceptable palatal closure, with the majority of patients
exhibiting excellent masticatory function. They also noted
that implantation of osseointegrated prostheses or dentures eliminated any major problems with mastication
in the remaining patients. Funk et al53 described a series
of patients who underwent free tissue transfer reconstruction of midfacial and cranio-orbital facial defects.
A subset of 5 patients had closure of large palatal defects
with a variety of soft tissue and composite free flaps. Criteria for palate closure with a soft tissue free flap included sufficient residual dentition to retain a dental pros-
thesis or, if the anatomy of the reconstruction would allow,
retention of an upper denture despite the absence of teeth.
When placement of osseointegrated implants was anticipated, the scapula osteocutaneous flap was preferred.55
In our series of patients, all of the above-mentioned
flaps except the iliac crest have been used. Free tissue transfer has been demonstrated to be a reliable single-stage
procedure to achieve separation of the oral and sinonasal
cavities. In addition, deglutition, speech, physical appearance, and an acceptable quality of life have been restored
for most patients.
Flap selection has been determined by a variety
of factors. The amount, location, and quality of residual
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Figure 5. A and B, Postoperative views of a patient who underwent left total
maxillectomy without orbital exenteration for adenoid cystic carcinoma of the
maxillary sinus. Following neutron beam radiation therapy, the patient
developed a sino-nasal-oral fistula. C, Defect involving the left hemipalate,
anterior maxilla, orbital floor, and a portion of the zygomatic arch. D, The
design of the rectus abdominis free flap. E, Cranial bone grafts used to
reconstruct the orbital rim, orbital floor, and malar eminence. F and G,
6-Month postoperative result, showing closure of the palatal defect and
cheek. Cheek projection is acceptable.
bone of the midface, dentition, and/or denture-bearing
alveolar arch largely determined the selection of a bonecontaining flap. In most patients with hemipalate defects, retention was sufficient to support a conventional
dental prosthesis so that fasciocutaneous or myocutaneous free flaps could be used in 8 of the 10 patients. In 2
of the 10 patients, radial forearm (osteocutaneous) free
flaps were used to improve anterior arch contour. How-
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Figure 6. A, Postoperative view of a patient who underwent left total maxillectomy with orbital exenteration for squamous cell carcinoma of the maxillary sinus.
B, Scapula–latissimus dorsi flap based on the subscapular artery, showing the latissimus dorsi with the thoracodorsal artery (right) and the scapula
(osteocutaneous) portion of the flap with the circumflex scapular artery (left). C, Postoperative computed tomographic scan with scapula bone in position,
creating adequate cheek projection. D, Postoperative result, showing closure of the palate. E and F, 6-Month postoperative results, with the orbital prosthesis
in place.
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ever, the osteocutaneous free flaps were not considered
suitable for placement of osseointegrated implants
(Figure 3).
In patients who underwent an inferior maxillectomy with subtotal or total palatectomy, very little retentive surface was available for a conventional prosthesis. These patients also lacked significant midface
projection resulting from loss of the anterior maxilla and
palate and therefore received a bone-containing flap
(11 fibula and 1 scapula). Bone-containing flaps create
the potential for implant-borne dental restoration.
Of the 12 patients, 2 required an additional free flap (radial forearm) to cover the additional soft tissue deficit
(posttraumatic). These also were the most complex reconstructions, and 9 of the patients required vein grafts
to achieve adequate pedicle length to reach the recipient vessels. At the time of this report, 6 of the patients
had undergone full restoration with dental prostheses
(Figure 4).
Total maxillectomy defects are challenging from both
a functional and an aesthetic perspective. These defects
result in a loss of a significant amount of bone and sometimes soft tissues of the cheek. Bone-containing flaps were
used in 20 of the 36 patients. The bone was used to reconstruct the orbital floor and the anterior arch. A scapula–
latissimus osteomyocutaneous flap was used in 12 of the
25 patients who underwent total maxillectomy with orbital exenteration. The addition of the latissimus dorsi
muscle was useful for both obliterating the large cavity
of the defect and improving facial contour.
In 7 of 17 patients for whom a myocutaneous flap
was used for reconstruction (either rectus abdominis or
latissimus dorsi), cranial bone grafts were used to carefully reconstruct the orbital floor or malar eminence.
Rectus abdominis fascia was used to recreate the floor
of the orbit in 4 of the 11 patients who underwent a
total maxillectomy without orbital exenteration. At the
time of this report, 3 of these patients had undergone
full restoration with dental prostheses (Figure 5 and
Figure 6).
Although maxillofacial prostheses have a role in primary reconstruction of palatal and maxillary defects, free
tissue transfers have been successful and are well accepted by a variety of patients. Excellent facial contour
and acceptable cosmetic results can be achieved consistently in a single-stage procedure. Functionally, patients enjoy the possibility for full dental restoration, masticatory function, and near normal phonation. The choice
of free tissue transfer and the type of flap required should
be tailored to the specific defect; denture-bearing potential of the native tissues; remaining supporting bone of
the midface, cheek and palate; and most importantly, the
patient’s needs.
Accepted for publication February 25, 2000.
Presented at the fall meeting of the American Academy of Otolaryngology–Head and Neck Surgery and the
American Academy of Facial Plastic Reconstructive
Surgery, New Orleans, La, September 23-25, 1999.
Corresponding author: Rudy J. Triana, Jr, MD, Otolarygology Department, Wake Medical Center, 3024 New
Bern Ave, Suite 305, Raleigh, NC 27610.
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