“We have to spend time on our health rather than spend time on diseases," says Nir Barzilai, M.D.
Nir, a renowned longevity researcher, joins us to discuss pharmaceutical interventions to delay aging, plus:
- What are gerotherapeutics? (~00:19)
- What you need to know about antagonistic nutrients (~04:25)
- Why healthcare costs don’t have to increase as people live longer (~08:55)
- SuperAgers vs. Blue Zones (~12:40)
- What are some science-backed longevity genes? (~15:14)
- The hallmarks of aging (~19:54)
- How metformin extends longevity (~22:46)
- Who is the right candidate for longevity drugs? (~25:03)
- The best age to take a longevity drug (~31:55)
- Lifestyle interventions for healthy aging (~34:17)
- Is fasting actually necessary? (~38:18)
- What to know about mTOR (~41:19)
- How to test your biological age (~43:10)
- What to do in your 20s and 30s for healthy aging (~48:16)
- The role of mindset in aging (~53:45)
- How repurposing drugs has saved lives (~57:45)
- Why women have the aging advantage (~01:03:42)

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Referenced in the episode:
- Nir's book, Age Later
- Nir's SuperAger study
- The SuperAgers family study
- Learn about the antagonistic pleiotropy hypothesis of aging
- Nir's study on metformin & aging
- TAME trial
- A study on metformin & COVID outcomes
- A study on metformin & muscle hypertrophy
- Nir's study on organ aging
- A study on metformin & IGF1
- A study on centenarians & IGF1
- Episodes #363, #217 & #170, with David Sinclair, Ph.D.
- Episode #207, with David Fajgenbaum, M.D., MBA, M.Sc., FCPP

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