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Agent-based modeling of the prostate tumor microenvironment uncovers spatial tumor growth constraints and immunomodulatory properties
Nature
Inhibiting androgen receptor (AR) signaling through androgen deprivation therapy (ADT) reduces prostate cancer (PCa) growth in virtually all...
4 months ago
Mathematical modeling of hypoxia and adenosine to explore tumor escape mechanisms in DC-based immunotherapy
Nature
Identifying and controlling tumor escape mechanisms is crucial for improving cancer treatment effectiveness.
1 month ago
In silico study of heterogeneous tumour-derived organoid response to CAR T-cell therapy
Nature
Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapy for treating cancers. This method consists in modifying the...
1 month ago
Targeting macrophages: a novel treatment strategy in solid tumors
Journal of Translational Medicine
In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) are the most abundant immune cells, which act as a key regulator in...
19 months ago
A war on many fronts: cross disciplinary approaches for novel cancer treatment strategies
Frontiers
Cancer is a disease characterized by uncontrolled cellular growth where cancer cells take advantage of surrounding cellular populations to obtain resources...
1 month ago
Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments
Journal of Translational Medicine
Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. Chimeric antigen receptor (CAR)-T cell...
12 months ago
Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends
Nature
Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-L1, novel targeting LAG-3 drugs have also been approved...
10 months ago
State-dependent evolutionary models reveal modes of solid tumour growth
Nature
Spatial properties of tumour growth have profound implications for cancer progression, therapeutic resistance and metastasis.
16 months ago
A multi-scale model for determining the effects of pathophysiology and metabolic disorders on tumor growth
Nature
The search for efficient chemotherapy drugs and other anti-cancer treatments would benefit from a deeper understanding of the tumor...
52 months ago
Simulation of avascular tumor growth by agent-based game model involving phenotype-phenotype interactions
Nature
All tumors, both benign and metastatic, undergo an avascular growth stage with nutrients supplied by the surrounding tissue.
103 months ago