A probabilistic model, CPEDetector, is presented for predicting whether or not a gene's translation is mediated by CPEB. CPEDetector takes into account detected ...
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What is translational regulation cytoplasmic polyadenylation?
Cytoplasmic polyadenylation is the process by which dormant, translationally inactive mRNAs become activated via the elongation of their poly(A) tails in the cytoplasm. This process is regulated by the conserved cytoplasmic polyadenylation element binding (CPEB) protein family.
What does cytoplasmic polyadenylation regulate?
Maternal mRNA translation is regulated in large part by cytoplasmic polyadenylation. This process, which occurs in both vertebrates and invertebrates, is essential for meiosis and body patterning.
What is the function of the cytoplasmic polyadenylation element?
Cytoplasmic Polyadenylation Element (CPE) refers to a nucleotide sequence found within the 3' UTR of mRNA molecules. It binds to the CPE-binding protein (CPEB) and plays a role in regulating translation and protein expression.
How is polyadenylation regulated?
The regulation of polyadenylation involves a complicated interplay between the numerous cis-elements surrounding the poly(A) site and trans-acting factors, of which several are RNA-binding proteins.
A probabilistic model, CPEDetector, is presented for predicting whether or not a gene's translation is mediated by CPEB. CPEDetector takes into account detected ...
Alignment and Analysis of Closely Related Genomes, 33. Computational Prediction of Genes Translationally Regulated by Cytoplasmic Polyadenylation Elements, 34 ...
Dec 6, 2020 · ... Computational prediction of genes translationally regulated by cytoplasmic polyadenylation elements. In: Rajasekaran S., editor ...
We propose that changes in mRNA polyadenylation are a conserved mechanism regulating protein expression during vertebrate oocyte maturation.
Feb 8, 2008 · A combinatorial code that determines whether an mRNA will be translationally repressed by CPEB, as well as the extent and time of cytoplasmic polyadenylation- ...
The papers address current research in the area of bioinformatics and computational biology fostering the advancement of computing techniques and their ...
Computational Prediction of Genes Translationally Regulated by Cytoplasmic Polyadenylation Elements. 353-361. Electronic Edition (link) BibTeX · Fahad Saeed ...
Apr 25, 2024 · Computational Prediction of Genes Translationally Regulated by Cytoplasmic Polyadenylation Elements. BICoB 2009: 353-361; 2004. [c1]. view.
The papers address current research in the area of bioinformatics and computational biology fostering the advancement of computing techniques and their ...