A probabilistic model, CPEDetector, is presented for predicting whether or not a gene's translation is mediated by CPEB. CPEDetector takes into account detected CPE sites, poly-A sites, and distance metrics between the detected locations.

Cytoplasmic post-transcriptional modification of mRNA transcripts in the form of polyadenylated (poly(A)) tails plays a key role in their translational control. The timing and degree of polyadenylation has been shown to be due in part to a consensus nucleotide sequence – cytoplasmic polyadenylation elements (CPEs) ...

Abstract. Cytoplasmic post-transcriptional modification of mRNA transcripts in the form of polyadenylated (poly(A)) tails plays a key role in their transla-.

The best studied example is the regulation of translation by cytoplasmic polyadenylation elements (CPEs) in the 3′ untranslated region of mRNAs involved in ... A more systematic investigation of the consensus CPE sequence and its maximum distance to the poly(A) signal would enable a more reliable bioinformatic prediction ...

A probabilistic model, CPEDetector, is presented for predicting whether or not a gene's translation is mediated by CPEB. CPEDetector takes into account detected ...

The timing and degree of polyadenylation has been shown to be due in part to a consensus nucleotide sequence -- cytoplasmic polyadenylation elements (CPEs) ...

Feb 8, 2008 · The polyadenylation-regulated translation is controlled by the cytoplasmic polyadenylation element (CPE) and its binding protein, CPEB, which can ... Using a combination of mutagenesis and experimental validation of genome-wide computational predictions, we show that the number and relative ...

Jun 14, 2013 · 86, 89-94 In these developmental stages transcription is absent and posttranscriptional regulation is therefore particularly important and more readily detectable. The factors mediating cytoplasmic polyadenylation of mRNAs have predominantly been characterized in Xenopus oocytes and early embryos.

Feb 8, 2008 · Cytoplasmic polyadenylation plays a key role in the translational control of mRNAs driving biological pro- cesses such as gametogenesis, cell-cycle progres- sion, and synaptic plasticity. What determines the distinct time of polyadenylation and extent of transla- tional control of a given mRNA, ...

Here, we performed tail-length and translational profiling of mRNA reporter libraries (each with millions of 3′ UTR sequence variants) in frog oocytes and embryos and in fish embryos. Contrasting to previously proposed cytoplasmic polyadenylation elements (CPEs), we found that a shorter element, UUUUA, together with ...