Oct 24, 2023 · RNA-binding proteins (RBPs) are key regulators of gene expression, but how RBPs convey regulatory instructions to the core effectors of RNA processing is ...

Dec 19, 2023 · ... regulated predominantly by mRNA motifs within the 3′-untranslated region (UTR), such as cytoplasmic polyadenylation elements (CPEs), among others (10). A ...

May 14, 2024 · Alterations in 3′UTR length affect the presence of binding sites for microRNAs and RNA-binding proteins, and can regulate mRNA stability and translation. More ...

Nov 23, 2023 · A reporter library for 5ÚTR cis-regulatory features that regulate translation during zebrafish embryogenesis. (A) Strategy for recovering 5´ UTR sequences.

Jan 29, 2024 · Overall, we have uncovered a highly dynamic and oscillatory pattern of translational reprogramming that contributes to the translational regulation of specific ...

Feb 2, 2024 · Given the diverse functions in cells, RBPs can be divided into epithelial splicing regulatory proteins (ESRP1), cytoplasmic polyadenylation element binding ...

Feb 6, 2024 · A self-cleaving ribozyme that maps to an intron of the cytoplasmic polyadenylation element-binding protein 3 (Cpeb3) gene is thought to play a role in human ...

Feb 1, 2024 · Our ability to determine the clinical impact of variants in 3′ untranslated regions (UTRs) of genes remains poor. We provide a thorough analysis of 3′ UTR ...

Mar 25, 2024 · Alternative transcription start site usage (ATSS) is a widespread regulatory strategy that enables genes to choose between multiple genomic loci for initiating ...

Nov 13, 2023 · We re-analyzed and harmonized data from previous studies that used genetic perturbations (mostly CRISPR interference (CRISPRi)) to inhibit candidate enhancers ...