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Adjusting for genetic confounders in transcriptome-wide association studies improves discovery of risk genes of complex traits
Nature
Many methods have been developed to leverage expression quantitative trait loci (eQTL) data to nominate candidate genes from genome-wide...
5 months ago
Editorial: Genetic Architecture and Evolution of Complex Traits and Diseases in Diverse Human Populations
Frontiers
Editorial on the Research Topic Genetic Architecture and Evolution of Complex Traits and Diseases in Diverse Human Populations. The research topic “Genetic...
5 months ago
Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
Nature
We develop a method, SBayesRC, that integrates genome-wide association study (GWAS) summary statistics with functional genomic annotations...
2 months ago
BridgePRS leverages shared genetic effects across ancestries to increase polygenic risk score portability
Nature
Here we present BridgePRS, a novel Bayesian polygenic risk score (PRS) method that leverages shared genetic effects across ancestries to...
6 months ago
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
Nature
Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry.
6 months ago
Considering strategies for SNP selection in genetic and polygenic risk scores
Frontiers
Genetic risk scores (GRS) and polygenic risk scores (PRS) are weighted sums of, respectively, several or many genetic variant indicator...
20 months ago
Rare Variants Imputation in Admixed Populations: Comparison Across Reference Panels and Bioinformatics Tools
Frontiers
BackgroundImputation has become a standard approach in genome-wide association studies (GWAS) to infer in silico untyped markers.
63 months ago
GhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies
Nature
Recent advances in genome sequencing and imputation technologies provide an exciting opportunity to comprehensively study the contribution...
19 months ago
Genomic Prediction Using LD-Based Haplotypes Inferred From High-Density Chip and Imputed Sequence Variants in Chinese Simmental Beef Cattle
Frontiers
A haplotype is defined as a combination of alleles at adjacent loci belonging to the same chromosome that can be transmitted as a unit.
35 months ago
Biobank-scale inference of ancestral recombination graphs enables genealogical analysis of complex traits
Nature
Genome-wide genealogies compactly represent the evolutionary history of a set of genomes and inferring them from genetic data has the...
14 months ago