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Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
Nature
GDNF receptor alpha-like is a brainstem-restricted receptor for growth and differentiation factor 15, regulating appetite and body weight in...
82 months ago
Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis
Nature
Obesity, a global health challenge, is a major risk factor for multiple life-threatening diseases, including diabetes, fatty liver,...
6 months ago
GDF15 tells the brain to lose weight
Nature
Obesity treatments that do not involve invasive surgery are greatly needed. Now, a team of scientists from Amgen provide evidence that...
80 months ago
Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation
Nature
GDF15 is a distant TGF-β family member that induces anorexia and weight loss. Due to its function, GDF15 has attracted attention as a...
39 months ago
Signaling pathways in obesity: mechanisms and therapeutic interventions | Signal Transduction and Targeted Therapy
Nature
Obesity is a complex, chronic disease and global public health challenge. Characterized by excessive fat accumulation in the body,...
23 months ago
Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum
Nature
Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3–2% of pregnancies and is associated with maternal and...
76 months ago
Volume 550 Issue 7675, 12 October 2017
Nature
The GTEx (Genotype-Tissue Expression) Consortium has established a reference catalogue and associated tissue biobank for gene-expression...
82 months ago