Jul 15, 2016 · Specifically, citalopram significantly reduced pain-related brain responses in l/l but not in s/s homozygotes.
Serotonin transporter polymorphism alters citalopram effects on human pain responses to physical pain ... To read the full-text of this research, you can request ...
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What is the role of serotonin in pain transmission?
Serotonin (5-HT) in the central nervous system (CNS) has been recognized as an important neurotransmitter and neuromodulator which regulates various physiological functions, such as pain sensation, cognition, and emotions–especially anxiety and depression.
Is there a link between serotonin transporter gene polymorphism and psychiatric disorders?
The human serotonin transporter (SERT) gene polymorphism (5HTTLPR) has been associated with multiple psychiatric disorders, including major depression, anxiety disorders, and substance use disorders.
What inhibits serotonin transporter?
SSRIs are the major class of psychotherapeutic drug targeting SERT. SSRIs act by blocking SERT, preventing the uptake of 5-HT from extracellular fluid, thereby increasing the strength and duration of 5-HT signaling.
What role does serotonin transporter play in depression?
The role of the serotonin transporter in MDD has been highlighted in gene by environment association studies as well as its role as a critical player in the mechanism of the most effective antidepressant treatments – selective serotonin reuptake inhibitors.
... Serotonin transporter polymorphism alters citalopram effects on human pain responses to physical pain. Ma Y, Wang C, Luo S, Li B, Wager TD, Zhang W, Rao Y ...
Serotonin transporter polymorphism alters citalopram effects on human pain responses to physical pain ... alters citalopram effects on human pain responses ...
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Polymorphism in the serotonin transporter gene has been associated with altered pain experience [13, 14]. Antidepressants affecting the monoaminergic system ...
... Serotonin transporter polymorphism alters citalopram effects on human pain responses to physical pain. Ma Y, Wang C, Luo S, Li B, Wager TD, Zhang W, Rao Y ...
Oct 15, 2023 · Serotonin transporter polymorphism alters citalopram effects on human pain responses to physical pain. Neuroimage. 2016; 135: 186-196. View ...
Jan 2, 2018 · Serotonin transporter polymorphism alters citalopram effects on human pain responses to physical pain. NeuroImage, Vol. 135, Issue. , p. 186 ...