Aug 27, 2024 · The coexistence of IGH-CCND1 and IGH-BCL6 rearrangements suggest that BCL6 and cyclin D1 may cooperate in the pathogenesis of DLBCL. CCND1 870G/A and CDH1 ...

Aug 17, 2024 · Immunoglobulin heavy locus gene rearrangements is associated with chronic lymphocytic leukaemia. The coexistence of IGH-CCND1 and IGH-BCL6 rearrangements ...

13 hours ago · Detects genetic abnormalities in cells, specifically the translocation between chromosomes 11 and 14, to diagnose B-cell lymphomas, like mantle cell lymphoma.

Aug 6, 2024 · ... IGH::CCND1 can also be performed at pathologist discretion to aid in diagnosis; for prognostic purposes, Ki-67 IHC should also be performed (prognostically ...

Aug 15, 2024 · The CCND1 region is indicated by vertical red lines. (D-E) Mean SNV burden per Mb on chromosomes 11 and 14 in NDMM samples with t(11;14)(CCND1;IGH) in VDJ ...

Aug 28, 2024 · Some of these (balanced) rearrangements, such as t(11;14)(q13;q32) or t(14;18)(q32;q21), can also be detected at the molecular level by PCR (IGH::CCND1, IGH:: ...

2 days ago · (A) The t(11;14) translocation is a key driver of oncogenesis in MM, juxtaposing the IGH enhancer to the CCND1 gene and inducing its overexpression. However ...

Aug 20, 2024 · Polyclonal immunoglobulin heavy chain (IgH) and immunoglobulin kappa light chain (IgK) gene rearrangements are characteristic of benign or reactive disease, ...

Aug 12, 2024 · CCND1 is a weak oncogene that requires the cooperation of other oncogenic ... Interestingly, WHSC1 (also named MMSET or NSD2) is the target of the IGH ...

2 days ago · ... IGH gene on chromosome 14q32 observed in 40 %-50 % of patients [6], both of ... CCND1 on chromosome 11, remains controversial [6], [11]. Translocation ...