Jul 7, 2024 · CCND1 Amplification Contributes to Immunosuppression and Is Associated With a Poor Prognosis to Immune Checkpoint Inhibitors in Solid Tumors. Downregulation of ...

Jul 7, 2024 · ... amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by ...

3 days ago · In most cancers, “amplification” was the primary genetic alteration type, and the highest amplification frequency of CCND1 (34.07%) occurred in cases with ESCA.

Jul 4, 2024 · RNA isolation and quantitative RT-PCR (qRT-PCR) analysis. The RT-PCR amplification was utilized to analyze mRNA expression. After a 48-h incubation, total RNA ...

Jul 19, 2024 · Prognostic and Predictive Value of CCND1/Cyclin D1 Amplification in Breast Cancer With a Focus on Postmenopausal Patients: A Systematic Review and Meta-Analysis ...

Jul 8, 2024 · Notably, up to one-third of FGFR1-amplified tumors also harbor amplification of CCND1 gene, which encodes for cyclin D1 protein. ... amplified tumors without ...

3 days ago · In most cancers, “amplification” was the primary genetic alteration type, and the highest amplification frequency of CCND1 (34.07%) occurred in cases with ESCA.

Jul 20, 2024 · CCND1 is overexpressed in 50% of breast cancers, which has been partially attributed to gene amplification. It is possible that enhancer hijacking may serve as ...

Jul 8, 2024 · Other FGFR alterations have been shown to promote endocrine resistance, including co-amplification of FGF 3/4/19 and CCND1, nuclear FGFR1 expression, FGFR3 ...

23 hours ago · Furthermore, amplification of the cyclin D1 (CCND1) gene is a frequent event in HNSCC, which has been reported to include 31% of the HPV− HNSCC (3).