Open Access
NeuroImage, volume 100, pages 642-649
Functional mapping of the auditory tract in rodent tinnitus model using manganese-enhanced magnetic resonance imaging
Da Jung Jung
1
,
Mun Han
2
,
Seong-Uk Jin
2
,
Sang Gyu Lee*
3
,
Il-Yong Park
4
,
HYUN-JU CHO
5
,
Tae-Jun Kwon
5
,
Hui Joong Lee
6
,
Jin Han Cho
7
,
Myung Hoon Yoo
1
,
Yongmin Chang
8, 9
3
Department of Otorhinolaryngology-Head and Neck Surgery, Daegu Veterans Hospital, Daegu, Republic of Korea.
|
Publication type: Journal Article
Publication date: 2014-10-01
Neurology
Cognitive Neuroscience
Abstract
Animal models of salicylate-induced tinnitus have demonstrated that salicylate modulates neuronal activity in several brain structures leading to neuronal hyperactivity in auditory and non-auditory brain areas. In addition, these animal tinnitus models indicate that tinnitus can be a perceptual consequence of altered spontaneous neural activity along the auditory pathway. Peripheral and/or central effects of salicylate can account for neuronal activity changes in salicylate-induced tinnitus. Because of this ambiguity, an in vivo imaging study would be able to address the peripheral and/or central involvement of salicylate-induced tinnitus. Therefore, in the present study, we developed a novel manganese-enhanced magnetic resonance imaging (MEMRI) method to map the in vivo functional auditory tract in a salicylate-induced tinnitus animal model by administrating manganese through the round window. We found that acute salicylate-induced tinnitus resulted in higher manganese uptake in the cochlea and in the central auditory structures. Furthermore, serial MRI scans demonstrated that the manganese signal increased in an anterograde fashion from the cochlea to the cochlear nucleus. Therefore, our in vivo MEMRI data suggest that acute salicylate-induced tinnitus is associated with higher spontaneous neural activity both in peripheral and central auditory pathways.
Top-30
Citations by journals
|
1
|
|
|
Frontiers in Aging Neuroscience
1 publication, 12.5%
|
|
|
Scientific Reports
1 publication, 12.5%
|
|
|
PLoS ONE
1 publication, 12.5%
|
|
|
Laryngoscope
1 publication, 12.5%
|
|
|
Toxicology Research
1 publication, 12.5%
|
|
|
1
|
Citations by publishers
|
1
|
|
|
Frontiers Media S.A.
1 publication, 12.5%
|
|
|
Springer Nature
1 publication, 12.5%
|
|
|
Public Library of Science (PLoS)
1 publication, 12.5%
|
|
|
Wiley
1 publication, 12.5%
|
|
|
Royal Society of Chemistry (RSC)
1 publication, 12.5%
|
|
|
1
|
- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2015,2016,2017,2018,2019,2020],"ids":[0,0,0,0,0,0],"codes":[0,0,0,0,0,0],"imageUrls":["","","","","",""],"datasets":[{"label":"Citations number","data":[1,3,2,1,0,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["12.5","37.5","25","12.5",0,"12.5"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Frontiers in Aging Neuroscience","Scientific Reports","PLoS ONE","Laryngoscope","Toxicology Research"],"ids":[13362,13767,24963,13135,711],"codes":[0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[12.5,12.5,12.5,12.5,12.5],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Frontiers Media S.A.","Springer Nature","Public Library of Science (PLoS)","Wiley","Royal Society of Chemistry (RSC)"],"ids":[208,8,344,11,123],"codes":[0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[12.5,12.5,12.5,12.5,12.5],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartiles":{"type":"bar","data":{"show":true,"labels":[2015,2016,2017,2018,2019,2020],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0,0,0,0],"percentage":["0","0","0","0","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[1,0,0,0,0,0],"percentage":["12.5","0","0","0","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[0,0,0,1,0,0],"percentage":["0","0","0","12.5","0","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[0,2,1,0,0,0],"percentage":["0","25","12.5","0","0","0"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[0,1,1,0,0,1],"percentage":["0","12.5","12.5","0","0","12.5"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by SCImago per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartilesWs":{"type":"bar","data":{"show":true,"labels":[2015,2016,2017,2018,2019,2020],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[1,0,0,0,0,0],"percentage":["12.5","0","0","0","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,0,0,0,0,0],"percentage":["0","0","0","0","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[0,2,1,1,0,0],"percentage":["0","25","12.5","12.5","0","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[0,0,0,0,0,0],"percentage":["0","0","0","0","0","0"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[0,1,1,0,0,1],"percentage":["0","12.5","12.5","0","0","12.5"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by WoS per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"updatedAt":"2024-07-22"}
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Jung D. J. et al. Functional mapping of the auditory tract in rodent tinnitus model using manganese-enhanced magnetic resonance imaging // NeuroImage. 2014. Vol. 100. pp. 642-649.
GOST all authors (up to 50)
Copy
Jung D. J., Han M., Jin S., Lee* S. G., Park I., CHO H., Kwon T., Lee H. J., Cho J. H., Yoo M. H., Chang Y. Functional mapping of the auditory tract in rodent tinnitus model using manganese-enhanced magnetic resonance imaging // NeuroImage. 2014. Vol. 100. pp. 642-649.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.neuroimage.2014.06.055
UR - https://doi.org/10.1016/j.neuroimage.2014.06.055
TI - Functional mapping of the auditory tract in rodent tinnitus model using manganese-enhanced magnetic resonance imaging
T2 - NeuroImage
AU - Jung, Da Jung
AU - Han, Mun
AU - Jin, Seong-Uk
AU - Lee*, Sang Gyu
AU - Park, Il-Yong
AU - CHO, HYUN-JU
AU - Kwon, Tae-Jun
AU - Lee, Hui Joong
AU - Cho, Jin Han
AU - Yoo, Myung Hoon
AU - Chang, Yongmin
PY - 2014
DA - 2014/10/01
PB - Elsevier
SP - 642-649
VL - 100
SN - 1053-8119
SN - 1095-9572
ER -
Cite this
BibTex
Copy
@article{2014_Jung,
author = {Da Jung Jung and Mun Han and Seong-Uk Jin and Sang Gyu Lee* and Il-Yong Park and HYUN-JU CHO and Tae-Jun Kwon and Hui Joong Lee and Jin Han Cho and Myung Hoon Yoo and Yongmin Chang},
title = {Functional mapping of the auditory tract in rodent tinnitus model using manganese-enhanced magnetic resonance imaging},
journal = {NeuroImage},
year = {2014},
volume = {100},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.neuroimage.2014.06.055},
pages = {642--649},
doi = {10.1016/j.neuroimage.2014.06.055}
}