Summary Gene expression changes over the lifespan and varies among different tissues or cell types. Gene co-expression also changes by sex, age, different tissues or cell types. However, gene expression under the normal state and gene co-expression in the human brain has not been fully defined and quantified. Here we present a database named Brain EXPression Database (BrainEXP) which provides spatiotemporal expression of individual genes and co-expression in normal human brains. BrainEXP consists of 4567 samples from 2863 healthy individuals gathered from existing public databases and our own data, in either microarray or RNA-Seq library types. We mainly provide two analysis results based on the large dataset: (i) basic gene expression across specific brain regions, age ranges and sexes; (ii) co-expression analysis from different platforms. Availability and implementation http://www.brainexp.org/. Supplementary information Supplementary data are available at Bioinformatics online.

中文翻译：

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BrainEXP：具有人脑中时空表达变化和共表达组织的数据库。

总结基因表达在整个生命周期中都会发生变化，并且在不同的组织或细胞类型中会有所不同。基因共表达也随性别，年龄，不同组织或细胞类型而改变。但是，人脑在正常状态下的基因表达和基因共表达尚未完全定义和量化。在这里，我们介绍了一个名为Brain EXPression数据库（BrainEXP）的数据库，该数据库提供了各个基因的时空表达以及在正常人脑中的共表达。BrainEXP包含来自2863名健康个体的4567个样本，这些样本是从现有的公共数据库和我们自己的数据（采用微阵列或RNA-Seq库类型）收集的。我们主要基于大型数据集提供两个分析结果：（i）跨特定大脑区域，年龄范围和性别的基本基因表达；（ii）来自不同平台的共表达分析。可用性和实施​​http://www.brainexp.org/。补充信息补充数据可从Bioinformatics在线获得。