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- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- Follows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- F.B.I. Special Agent Seeley Booth teams up with the Jeffersonian's top anthropologist, Dr. Temperance Brennan, to investigate cases where all that's left of the victims are their bones.
- Adrian Monk is a brilliant former San Francisco detective, who now consults the police as a private consultant while battling with an obsessive-compulsive disorder.
- Shaun Murphy, a young surgeon with autism and Savant syndrome, is recruited into the surgical unit of a prestigious hospital.
- A young woman with a troubled past is drawn to a small town in Maine where fairy tales are to be believed.
- Professional writer and amateur sleuth Jessica Fletcher uses her intellect, charm, and persistence to get to the bottom of every crime she encounters.
- Los Angeles homicide detective, Lieutenant Columbo, uses his humble ways and ingenuous demeanor to root out even the most well-concealed crimes.
- A group of ambitious misfits try to escape the harsh realities of high school by joining a glee club headed by a passionate Spanish teacher.
- Four friends band together against an anonymous foe who threatens to reveal their darkest secrets, while also investigating the disappearance of their best friend.
- The misadventures of a talking sea sponge who works at a fast food restaurant, attends a boating school, and lives in an underwater pineapple.
- Emily arrives home hoping to visit her parents, only to find that they are going on a trip of their own. While she stays at her house for the holidays, her HOA is determined to get Emily involved in the neighborhood Christmas festivities.
- A former White House Communications Director starts her own crisis management firm only to realize her clients are not the only ones with secrets.
- Three parapsychologists forced out of their university funding set up shop as a unique ghost removal service in New York City, attracting frightened yet skeptical customers.
- A new medical director breaks the rules to heal the system at America's oldest public hospital.
- An unfairly discredited but brilliant ER doctor winds up working with his younger brother in the Hamptons as a concierge doctor to the uber-rich and ultra-elite.
- Twin siblings Dipper and Mabel Pines spend the summer at their great-uncle's tourist trap in the enigmatic Gravity Falls, Oregon.
- A 12-year-old boy and his best friend, a wise 28-year-old dog with magical powers, go on a series of surreal adventures in a remote future.
- When two kids find and play a magical board game, they release a man trapped in it for decades - and a host of dangers that can only be stopped by finishing the game.
- The Dark Knight of Gotham City begins his war on crime with his first major enemy being Jack Napier, a criminal who becomes the clownishly homicidal Joker.
- The daily trials and tribulations of Tim "The Tool Man" Taylor, a television show host raising three mischievous boys with help from his loyal co-host, loving wife, and eccentric neighbor.
- Boston's assertive detective Jane Rizzoli and steady medical examiner Maura Isles are hailing from very different economic backgrounds, but the strong, competent women effectively work together to solve the city's most puzzling crimes.
- Boston Legal is a spin-off of the long-running David E. Kelley series The Practice (1997), following the exploits of former Practice character Alan Shore (James Spader) at the legal firm of Crane, Poole, and Schmidt.
- Covering the continuing adventures of series protagonist Ash Ketchum and Pikachu, and his best friend Brock, the two meet a new coordinator named Dawn, who travels with them through Sinnoh and enters Pokemon Contests.
- Three brothers are surprised when they find themselves forced to care for a baby during the holidays, during the journey they begin to rebuild their relationships as brothers while rediscovering their love for Christmas.