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Working for the F.B.I., a mathematician uses equations to help solve various crimes.

When Don and his team find a strange code during a raid, Charlie suspects it is part of a plan to assassinate a Columbian exile living in Los Angeles.

The team investigates a jewelry store theft where the robbers kidnapped the owner's wife and daughter.

The murder of a young museum researcher sends the team on a search for a killer and a missing Native American skull.

Don takes under his wing the son of a murdered executive as the team and Charlie try to narrow down who's responsible out of a pool of six thousand or more.

Charlie searches for a link between robberies when the number of violent home invasions in an upscale neighborhood suddenly escalates.

The investigation of two teens leads Don and his team to counterfeiting ring.

A truck of nuclear materials is stolen by terrorists who intend to use the materials to make a bomb which would then be used on the city of LA. Only Charlie and Charlie's father Alan can save the city from a small nuclear blast.

Charlie and the team investigate a murder at a casino.

A crime scene drenched in blood leads the team to a form of human trafficking, and Amita to her past.

When Riley, who practiced an ingenious pyramid method of skimming numerous bank accounts for over half a million dollars, is strangled, exactly the same way -not revealed to the press- as Lisa Bayle, for whose murder Don Eppes' investigation once put Cliff Howard in jail after a plea bargain-confession, Don now fears the wrong man was arrested. Charlie helps him quantify the unlikeliness of a coincidence and seriously doubt the forensic evidence. Electrician Jose Salazar, whom Don suspects, still turns out to be innocent of Lisa's murder, but Charlie realizes that's not the point: what if a third person committed both murders, linked rather by the victims?

When Charlie finds a disturbing photo on a computer confiscated in a raid on a methamphetamine lab, he takes it to heart and pursues its origins against Don's orders.

When the wife of a judge is killed the team investigates. And they discover that it might not be for the reason they think.

Don and his team track two violent prison bus escapees.

Don asks Charlie to help determine a mysterious aircraft's point of origin and is surprised when the probe turns into a murder investigation.

A pop star is receiving death threats from an obsessed stalker but Charlie is convinced the letters are written by two different people.

When a rapist proves a little too difficult to find for the FBI, Agent Eppes and Agent Lake utilize Agent Eppes' genius mathematician brother, Charlie, to discover the rapist's point of origin.

A genius' (Harris) daughter is captured by two men looking to use his possible solution to a 150 year old math equation for heists.

An unknown terrorist is mimicking horrible train accidents and leaving a number code at the scene.

Dr. Larry Fleinhardt's former college days friend Jonas Hoke, the Senior computer-science researcher, who develops for Robert Oliver's firm Lorman group with gifted college drop-out Scott Reynolds a classified program to evaluate government projects, is murdered in his Hollywood Hills home; data were stolen from his computer, which only contains a coded program for analysis of baseball statistics. Hoke's financial divorce complications seem irrelevant, although his wife had a relationship with their security system installer Lucas Grant. However Charlie finds that Hoke actually used the same kind of advanced statistic analysis and performance prediction on other data, cleverly masked under meaningless baseball numbers: Hoke applied this method cutting-edge to calculate human performance prospects in real life, based on various governmental and other data, potentially far more valuable...

Charlie seeks out an engineering professor to help him recreate a fire scenario to solve an arson case.

Don and his team call on a senior sniper instructor from Quantico to help stop a marksman who goes on a killing spree in Los Angeles.

When a death results from an anti-terrorism exercise Don and his team are called in, but they end up butting heads with the leader of the unit who refuses to halt further training exercises. Back at home, Alan has volunteered the house for the wedding of a girl both Charlie and Don had a crush on in high school.

The mysterious suicide of a brilliant but unfocused CalSci engineering major leads Eppes and Charlie to the site of an iconic building.

Charlie uses math to determine the killer of an undercover FBI agent.