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A premiere surgeon is blackmailed in a plot to assassinate the president after her family is taken hostage by a rogue federal agent.

The family of a doctor, who will be doing surgery on the United States President, is taken hostage by a rogue FBI agent. She is ordered by the kidnappers to assassinate the President in order to save her family.

Ellen's refusal to assassinate the President during surgery could cost her a family member's life. HILARIE BURTON (One Tree Hill) appears as Samantha, Brian's mistress.

Ellen and Brian devise a plan with their kids to escape from Duncan. Meanwhile, Duncan's wife, Nina (FRANCIE SWIFT), tells him that she wants to discontinue her treatment.

Duncan threatens Ellen to convince the President to keep her on as his surgeon ... or else. Plus, Ellen meets Duncan's daughter (LOLA COOK) and gains insight into his life.

Ellen has to make another life-changing choice when she performs emergency surgery in her own home. Meanwhile, Duncan demands answers when Archer tells him that an innocent person in their plan has become a victim.

Duncan locks the Sanders family in a room for the day while he and his team head to New York City to eliminate the sniper team targeting President Kincaid. Meanwhile, Duncan's mother-in-law, Kate, tells Burton she wants to expose the President.

Ellen must decide whether to save Duncan's life, and later decides to confront his wife. Meanwhile, Creasy meets with Vanessa and Colonel Blair after the President informs them that he wants to expose the details of Operation Total Information, a government surveillance program that allowed intelligence agencies to spy on U.S. citizens.

When investigators get closer to discovering the conspiracy to kill the President, Duncan is ordered to get rid of an insider by someone very connected to the plot. Meanwhile, Duncan takes the next step in his master plan and gives Ellen the poison she is to use to kill the President.

After a member of the President's staff is murdered, Ellen urges Duncan to back out of the assassination plot, while other members of the President's staff take matters into their own hands. Meanwhile, after scouring medical records, Ellen finds someone who might be a viable bone marrow donor for Duncan's wife, Nina.