- Is an accomplished singer (as demonstrated in Virtuoso (2000) and The Swarm (1996)) and has put out a CD of parody songs.
- Is the only "Star Trek" regular to have ever written an episode of "Star Trek": the sixth-season episode Life Line (2000).
- Had originally auditioned for the role of Neelix on Star Trek: Voyager (1995), which went to his co-star Ethan Phillips.
- He has played the same character (Richard Woolsey) on three television series: Stargate SG-1 (1997), Stargate: Atlantis (2004) and Stargate Universe (2009).
- Spoke the final line of the television series Stargate: Atlantis (2004).
- Originally attended Yale University as a Pre-Med major (and, ironically enough, played the holographic doctor on Star Trek: Voyager (1995)), but later received his Bachelor's degree in Drama.
- Has two daughters with his wife Linda Picardo: Nicollette Arianna (born March 14, 1989) and Gina Emira (born November 3, 1991).
- Made obvious in several scenes in Virtuoso (2000) and The Swarm (1996), he is an accomplished singer. While he was at Yale University, he was a member of the Society of Orpheus and Bacchus, the second longest running undergraduate a Capella group in the United States. Then in 1977, he made his Broadway debut. He appeared in Gemini (1977) and Tribute (1980).
- Best known as the holographic doctor on Star Trek: Voyager (1995), he also played a doctor on China Beach (1988) and the sitcom episode The Operation (1986).
- Is a huge fan of Stargate SG-1 (1997) on which he plays the recurring character of Agent Richard Woolsey.
- He has appeared with Dick Miller in eleven films: The Howling (1981), Get Crazy (1983), Explorers (1985), Innerspace (1987), Amazon Women on the Moon (1987), The 'Burbs (1989), Gremlins 2: The New Batch (1990), Motorama (1991), Matinee (1993), The Second Civil War (1997) and Looney Tunes: Back in Action (2003).
- Comes from the East Falls section of Philadelphia, Pennsylvania.
- Has appeared in episodes of two different series entitled "The Gift" and "One Small Step": China Beach (1988) and Star Trek: Voyager (1995).
- He has appeared with Belinda Balaski in six films: The Howling (1981), Explorers (1985), Amazon Women on the Moon (1987), Gremlins 2: The New Batch (1990), Matinee (1993) and The Second Civil War (1997).
- Has appeared in episodes of two different series entitled "Prototype": Prototype (1996) and Prototype (2005).
- Attended and graduated from William Penn Charter School in Philadelphia, Pennsylvania (1971).
- Italian-American.
- He has appeared concurrently on The Wonder Years (1988) and China Beach (1988). Both television series were set in an earlier time period of the 1960s/1970s.
- He has appeared in ten films or television films directed by Joe Dante: The Howling (1981), Explorers (1985), Innerspace (1987), Amazon Women on the Moon (1987), The 'Burbs (1989), Gremlins 2: The New Batch (1990), Matinee (1993), The Second Civil War (1997), Small Soldiers (1998) and Looney Tunes: Back in Action (2003), Dante has also directed him in five television episodes: Boo! (1986), Runaway Daughters (1994), Homecoming (2005), Boo (2007) and Olelo Pa'a (The Promise) (2013).
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