- In a 2005 interview with Tom Brokaw, she stated that even though then husband Carl Bernstein didn't make her privy to the identity of Watergate informant "Deep Throat," she figured it out from clues (including Bernstein's notes referencing the initials "M. F." -- allegedly for "my friend") and was willing to tell her guess to anyone who asked. Her guess was proved correct when on May 31, 2005, Mark Felt, former assistant director of the FBI during the Richard Nixon administration, was identified as Deep Throat.
- Upon her death, it was revealed that Ephron had been diagnosed only a few years before with myelodysplastic syndrome, a pre-leukemic condition. It was a secret she shared with only a few close famly members and friends.
- New York, NY, USA: Eight months after her death, Ephron's play 'Lucky Guy' opens on Broadway for a limited run starring her longtime friend Tom Hanks. (February 2013)
- In her most recent book, "I Remember Nothing," she ends the collection of essays with two lists: What I Won't Miss, and What I Will Miss. After the lists come the acknowledgments, which ends with "and of course, my doctors."
- Sons: Jacob Bernstein and Max Bernstein.
- Used to live in famous Manhattan apartment house on the West side called the Apthorp.
- Portrayed by Grace Gummer in Good Girls Revolt (2015). Gummer's mother, Meryl Streep, starred in three films written by Ephron: Silkwood (1983), Heartburn (1986) and Julie & Julia (2009).
- As shown in Can You Ever Forgive Me? (2018), author and forger Lee Israel liked making drunken prank calls to literary agents impersonating Ephron; ultimately Ephron's lawyers sent her a cease-and-desist letter.
- She was of Russian Jewish and Belarusian Jewish descent.
- Went to Beverly Hills High School as did Angelina Jolie, Michael Klesic, Nicolas Cage, Lenny Kravitz, Gina Gershon, Richard Dreyfuss, Jonathan Silverman, and David Schwimmer.
- Daughter of Henry Ephron and Phoebe Ephron.
- Sister-in-law of Jerome Kass (husband of sister Delia).
- Ex-sister-in-law of Sasha Harari (husband of sister Amy).
- Aunt of Anna Harari, Maia Harari and Ethan Harari.
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