- Daughter, Marina LeBlanc, was diagnosed with a rare brain disorder that affects her motor skills. Matt and Melissa were concerned when their 11 month old started having seizures. At age two, Marina's condition had largely improved.
- His character, Joey, in Friends (1994 - 2004) once attempted to learn French and was extremely bad at it. In real life, he is fluent in the language.
- He is of French-Canadian (father) and Italian (mother) descent. Is fluent in French.
- Also works as a model. Is a trained carpenter. Interested in parachute jumping, car racing and landscape photography.
- For eight years was in a relationship with former Joey (2004) co-star Andrea Anders until 2014.
- Scored the fastest lap on Top Gear for the Star In A Reasonably Priced Car driving the Kia Cee'd at 1:42.1 beating Rowan Atkinson (1:42.2) and Michael Fassbender (1:42.8 [on ice]).
- Became a father for the 1st time at age 36 when his wife Missy McKnight gave birth to their daughter Marina Pearl LeBlanc on February 8, 2004.
- Has a tattoo of a bike chain around his right bicep and above it is the name of his daughter, Marina Pearl.
- In November 2006 (right after his divorce) he paid $7.4 million for a four-bedroom, 3930-square-foot house in Los Angeles' Pacific Palisades area.
- Is the only cast member of Friends (1994) not to have appeared on Saturday Night Live (1975).
- Has a half brother named Justin who lives in Australia.
- His role of "Maj. Don West" in Lost in Space (1998) was originally offered to his Friends (1994) co-star Matthew Perry.
- Dated Kate Hudson in 1996.
- Stepfather to Tyler and Jacqueline from his ex-wife's first marriage. On The Late Show with Stephen Colbert (2015) in October 2016, when asked about his kids, he says he has "three: a 25, a 22 and a 12".
- At one time he was known as the king of the commercials. As well as a 1987 Heinz ketchup commercial that won top prize at Cannes, he appeared in slots for Levi's 501 jeans, Doritos and Coca-Cola. One of his commercials can be seen on a TV screen in Tequila Sunrise (1988).
- Has three dogs: Lady, Shadow and Jay.
- Appears in an advert for Heinz Tomato Ketchup that aired in Britain in the 1980s, where he lines up a Ketchup Bottle on a tall building so that when he buys a hotdog down in the street, he can hold it out and catch the Ketchup on it. Because "the best things come to those who wait" was their slogan.
- Sold his six-bedroom, 11,158-square-foot mansion in Hidden Hills, California for $9,139,000. He purchased it in late 2005 for exactly $9 million. (2008)
- Early modeling jobs included posing for cover of a gay travel guide, Damron Travel Guide For Men.
- Is a motorcycle enthusiast and hosted his own TV show, The 5 Coolest Things (2003), based on the 5 coolest things in each motorcycle specialty (off-road, motocross, road racing, freestyle).
- Attended the Wentworth Institute of Technology in Boston for just over a semester, leaving during the second semester of his freshman year.
- Lives in Pacific Palisades and Los Alamos, California.
- In 2000, named one of the 50 Most Beautiful People by People Magazine.
- Matt and his Friends (1994) co-star Matthew Perry both guest starred in the short-lived sitcom Just the Ten of Us (1987), although not in the same episodes.
- Went to same Junior High and High School as Louis CK. In 1982 they went to FA Day Junior High School. In 1985 they went to Newton North High School in Newton, Massachusetts.
- Engaged to Missy McKnight on November 1998, married her on May 2003, filed for divorce on April 1, 2006, and divorced her on October 2006.
- 1985: Graduated from Newton North High School, Newton, Massachusetts.
- He is a lifelong Democrat.
- Won a Golden,Lion Award for a Heinz Ketchup ad in which he dripped sauce off a rooftop and makes it to the ground to catch it in a sandwich.
- In commercials for Levis, Coca Cola, and Doritos.
- Born at 4:18am-EDT
- In Los Angeles recording Joey (2004). (September 2004)
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