- Fences with his brother and used to fence with Taran Noah Smith of Home Improvement (1991) when they worked on the same ABC lot.
- In 1993 and 1994, Jonathan won the Hollywood Youngstar Award for Outstanding Younger Actor in a Drama Series, also due to his portrayal of "Lucky" (a.k.a. Lukas Lorenzo Spencer Jr.) on General Hospital (1963).
- He attended the ABC Kids N Teens acting and modeling program.
- Plays guitar.
- Was named one of People Magazine's 50 Most Beautiful People (1999).
- Daughter Adora Jackson was born in July 2005.
- Older sister, Candace Jackson, used to act and is now a lawyer.
- Graduated high school when he was 16.
- Son, Caleb Jackson, born June 21, 2003, which was also the one year anniversary of his marriage to actress Lisa Vultaggio.
- Had a band, Scarlet Road, with his brother, father and uncle. Now in band, Enation, with his brother, Richard Lee Jackson.
- Father is a Family Practice Physician who ran for a Congress in Washington State.
- Jonathan's father, Ricky Lee, is a doctor. His mother, Jeanine's a business manager.
- He was to have had a major role in The Seeker: The Dark Is Rising (2007) but his part was cut entirely after filming was completed.
- Has an older brother, actor-musician Richard Lee Jackson, and an older sister, Candace Jackson.
- Over the years, Jackson has been cast in two movies that lost their funding half-way through shooting: "The New Kid" in 1994 and "Six Wire Winter" in 2003. "The New Kid" also co-starred his brother, Richard Lee Jackson, and would have been Jonathan's film debut, but the movie lost funding and was never released. "Six Wire Winter" was to co-star Willie Nelson, but funding fell through and shooting was halted.
- Son, Titus Gabriel Jackson, born 7 October 2010.
- His ancestry includes English, German, Finnish, all three Scandinavian countries (Denmark, Norway, and Sweden), Scottish, and Scots-Irish (Northern Irish), as well as distant Dutch and French roots.
- Has returned to the role he originally created as Lucky Spencer on ABC's General Hospital (1963), in 2009.
- In 2012, Jackson and his family were baptized into the Greek Orthodox church.
- Lead singer of the band Enation, which just released the album "Where the Fire Starts". (February 2007)
- In a symbolic gesture, offered his 2005 Emmy award to the Holy and Great Monastery of Vatopedi in Mount Athos, Greece. During his recent visit of 15 August, 2018, he took the award with him and took part on the vigil with the monks, to whom he revealed his offer.
- He wanted to be a professional baseball player when he was younger.
- Since being baptized into the Ortodox Greek church, has expressed his admiration for the monks of Mount Athos and their commitment to their beliefs.
- Filming The Seeker: The Dark Is Rising (2007) in Romania. (February 2007)
- Very active in Republican politics.
- Shares his birthday with Cory Monteith.
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