- Amy is so often mistaken for friend Isla Fisher that Isla and her prankster husband Sacha Baron Cohen once pasted Amy's face over Isla's on their custom holiday greeting cards with the message, "Season Greetings from Sacha, Isla and the Kids." Apparently, no one noticed.
- She has appeared in five films that have been nominated for the Best Picture Oscar: The Fighter (2010), American Hustle (2013), Her (2013), Arrival (2016) and Vice (2018).
- Did her own singing in The Muppets (2011), Enchanted (2007) and Miss Pettigrew Lives for a Day (2008).
- Best friends with actress Emily Blunt. The two became very close while filming Sunshine Cleaning (2008).
- Is a trained dancer.
- Was admittedly so distracted by co-star Lee Pace while filming Miss Pettigrew Lives for a Day (2008), since "he just looked so dashing", that the director had to ask him leave the set.
- Meryl Streep taught her how to knit.
- Was 1 month pregnant with her daughter Aviana when she completed filming on The Fighter (2010).
- Was born on the U.S. military base located in Aviano, Italy, but spent part of her childhood in the U.S. military base located in Vicenza, Italy.
- She and Leonardo DiCaprio were both 28 years old when they portrayed teenage lovers in Catch Me If You Can (2002). Adams considered that film to be a turning point in her career.
- Worked in a Hooters Restaurant until soon after she turned 18, when they started making her wear the customary outfits.
- During a red carpet interview at the 81st Academy Awards, she claimed to suffer from extreme stage fright and claustrophobia.
- She was born in Italy and raised in Castle Rock, Colorado.
- Her favorite films include Gone with the Wind (1939), The Wizard of Oz (1939), Casablanca (1942), Vertigo (1958), The Shawshank Redemption (1994), Paulie (1998) and O Brother, Where Art Thou? (2000).
- As a gesture of support to the U.S. troops, she privately gave her first-class seat to an American soldier who was on the same flight from Detroit to Los Angeles in 2014. She gladly took a seat in standard coach.
- Her father was in the military and was also an amateur actor.
- She had considered quitting acting before doing the film Junebug (2005).
- Auditioned for Lois Lane twice before being cast in Man of Steel (2013). She first auditioned for the cancelled project "Superman Flyby" and Superman Returns (2006).
- Was in attendance at the wedding of her Sunshine Cleaning (2008) co-star and best friend Emily Blunt to John Krasinski (July 10, 2010).
- Is a natural blonde. Dyes her hair red.
- Is one of seven children of Kathryn (Hicken) and Richard Kent Adams.
- She was awarded a Star on the Hollywood Walk of Fame at 6280 Hollywood Boulevard in Hollywood, California on January 11, 2017. Introduced by her Arrival (2016) co-star, Jeremy Renner, and director, Denis Villeneuve.
- Her performance as Ashley Johnsten in Junebug (2005) was named the sixth best performance of the decade in Paste magazine's 25 Best Movie Performances of the Decade.
- Has made two movies back-to-back starring Meryl Streep: Doubt (2008) and Julie & Julia (2009). In the latter, she has no scenes with Streep.
- Tenth highest paid actress of 2017 with $11.5 million.
- Her brother, Eddie Adams, works for the tabloid show TMZ.
- Wanted to be a singing nurse as a child.
- Mother, with husband Darren Le Gallo, of a daughter Aviana Olea Le Gallo (b. May 15, 2010).
- As of 2019, the longest she has gone without an Oscar nomination, since her first one, is six years, between American Hustle (2013) and Vice (2018).
- Named one of Time magazine's 100 Most Influential People in the World. (April 2014)
- Met her boyfriend, Darren Le Gallo, in 2001 in an acting class.
- In elementary school, she was diagnosed with ADHD and prescribed Ritalin, which she still takes as an adult. Attended and graduated from Douglas County High School in Castle Rock, Colorado.
- Enjoys singing karaoke.
- She didn't attend drama school or study acting.
- Has appeared in the series episode, Craving (2001), which is about the early life of Clark Kent before he became Superman. She later went on to play Superman's main love interest, Lois Lane, in Man of Steel (2013). Is one of several actors who guest starred on the series and returned in the Superman film, along with Alessandro Juliani, Tahmoh Penikett and David James Lewis.
- Named one of People magazine's 100 Most Beautiful People in the World (2008).
- Adams, Leonardo DiCaprio, Tilda Swinton, Marion Cotillard, Emma Thompson, Tom Hanks, Daniel Brühl and Jake Gyllenhaal are the only actors to receive a Golden Globe, SAG, BAFTA and Critics' Choice Award nomination for the same performance and then fail to be Oscar-nominated for it: for their performances in Arrival (2016), The Departed (2006), We Need to Talk About Kevin (2011), Rust and Bone (2012), Saving Mr. Banks (2013), Captain Phillips (2013), Rush (2013) and Nightcrawler (2014), respectively.
- Is just 10 years younger than Laura Linney, who played her mother in Nocturnal Animals (2016).
- Once worked at Gap, a clothing store chain.
- Her ancestry includes English, as well as smaller amounts of Danish, Swiss-German, and Norwegian, and more distant Welsh, German, Irish, Scottish, and Scots-Irish/Northern Irish.
- For a time Amy's teenage crush was future co-star Leonardo DiCaprio during his stint in Growing Pains (1985).
- She and Gal Gadot are the first live action Lois Lane and Diana Prince/Wonder Woman to be onscreen together.
- The first job she ever had (at age 12) was selling licorice at a rodeo in Ogden, Utah, while staying with her grandparents. She later worked as a 'greeter' at The Gap store in the Lenox Mall in Buckhead, Atlanta, where she once had rare opportunity to greet Whitney Houston as she entered the store. Whitney didn't take too kindly to Amy's cloying store formalities and quickly requested a different salesperson to assist her.
- Alumna of the Chanhassen Dinner Theatre in Minnesota. Appeared there in many productions including "Brigadoon" and "Good News.".
- Second actress with red hair to portray Lois Lane (preceded by Noel Neill).
- Returned to work 3 months after giving birth to her daughter Aviana in order to begin filming On the Road (2012).
- Invited to join the Academy of Motion Picture Arts and Sciences (AMPAS) in 2006.
- Through her sixth generation great-grandparents Thomas and Elizabeth Shipp is a fifth cousin twice removed of Harry S. Truman. Through the same Shipp ancestors is a seventh cousin once removed to both Johnny Depp and John Edwards.
- Friends with Bradley Cooper.
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